Viral Hepatitis Flashcards Preview

Unit 6: Pathology > Viral Hepatitis > Flashcards

Flashcards in Viral Hepatitis Deck (25):
1

What are other causes of hepatitis besides hepatitis viruses?

EBV and CMV

2

Which type of bilirubin is increased in hepatitis?

both CB and UCB

3

How do you distinguish acute from chronic viral hepatitis?

chronic - symptoms last > 6 months

4

What is the appearance of the liver in acute hepatitis?

lobular disarray, liver cell death
central phelbitis, endophlebitis
councilman bodies

5

What are councilman bodies

pyknotic nucleus extruded from liver cells

6

Chronic hepatitis presents with a sepctrum of inflammation, name some types of these pathologies?

1. focal periportal necrosis
2. portal tract lesions - proliferation of bile ductules
3. intralobular lesions
4. periportal fibrosis

7

What is confluent hepatitis necrosis

death of hepatocytes in geographical distribution
affects whole regions of lobule

8

What is the most common cause of confluent hepatitis necrosis?

hep B

9

What is the method of transmission of each of the hepatitis viruses?

hep A and E - fecal oral
Hep B, C - parenteral

10

Which hepatitis virus is most common?

hep A

11

What are some prototypical types of people that acquire hep A?

travelers, MSM, day care children

12

What is the main source from which people contract hep E

contaminated water (uncercooked seafood)

13

What type of immunoglobulin indicates active infection?

IgM

14

What is the first serologic marker to rise in Hep B?

HbsAg

15

What defines the chronic state of HepB?

HbsAg present for >6 months

16

When is the core antibody present?

acute battle and window phase

17

What is the sign of victory of beating hep B?

IgG production

18

What does the presence of the envelop antigen indicate? when is it present?

infectivity
present during acute phase and can be present chronically

19

What is the hep B vaccine composed of?

recombinant HBsAg

20

What are some extrahepatic manifestations of the hep B virus?

Ab-ag complex causes:
serum sickness
polyarteritis
glomerulonephritis
cryoglobulinemia

21

How do you confirm infection with hep C? how long would you need to wait

HCV RNA test
-can be detected within 2 weeks

22

What indicates hep C recovery?

dec RNA levels

23

What are some extrahepatic manifestations with hep c?

1. mixed cryoglobulinemia --> systemic vasculitis
2. membranoproliferative GN
3. B cell non hodkin lymphomas

24

What is the most common indication for a liver transplantation?

infection with hep C

25

Hep D needs Hep B to infect, is superinfection or coinfection a more severe infection?

superinfection