Liver - Jaundice Flashcards Preview

Unit 6: Pathology > Liver - Jaundice > Flashcards

Flashcards in Liver - Jaundice Deck (18):
1

What is the earliest sign of jaundice?

scleral icterus

2

What specifically makes stool brown and urine yellow?

urobilinogen

3

What happens to cause jaundice in extravascular hemolysis or ineffective erythropoeisis?

high levels of UCB overwhelm ability of liver to conjugate

4

What are the clinical manifestations of extravascular hemolysis/ineffective erythropoeisis?

dark urine - inc urobillinogen!
- inc risk for bilirubin gallstones due to inc UCB

5

Why does an ittybitty new baby get yellow?

transient low UGT activity

6

What are two reasons why premature infants are more susceptible to becoming bananna colored?

hepatic clearance less developed
turnover RBCs is more pronounced

7

in all seriousness, why is jaundice in a baby dangerous?

UCB is fat soluble and can deposit in BG
-kernicterus
-can lead to neuro deficits and death

8

Whats the treatment for the sunshine colored babies

phototherapy

9

What is gilbert syndrome?

mildly low UGT activity

10

What are the clinical manifestations of gilbert?

jaundice during stress

11

What is crigler naijar?

EVIL VILLAIN that STOLE THE UGT
(absent UGT)

12

What is dubin johnson syndrome?

deficiency of bilirubin canalicular transport protein
-impaired transport into canaliculus

13

What is the pathology of dubin johnson syndrome?

black liver but no other problems -

no bitches no problemz (think that dubin johnson sounds like a black NBA supastar)

14

What are some things that can cause obstructive jaundice?

1. gallstones
2. pancreatic carcinoma
3. cholangiocarcinoma
4. parasites
5. liver fluke

15

What are some physical symptoms of biliary tract obstruction besides jaundice?

pruiritus - inc bile acids in skin
xanthomas - hypercholesterolemia
steatorrhea
malabsorption of fat soluble vitamins
dark urine

16

What is the pathological appearance of billiary duct obstruction?

liver is swollen and bile stains
-feathery degeneration
1. hydropic swelling
2. bile pigment
3. reticulated

17

Which causes of jaundice cause inc UCB?

Neonatal jaundice
Gilbert and crijjar
Hemolysis and ineffective hematopoiesis
Viral hepatitis and cirrhosis -mixed

18

What causes CB jaundice

Biliary tract obstruction
Primary sclerosing cholangitis
Primary biliary cirrhosis
Hepatitis and cirrhosis - mixed