Liver - Jaundice Flashcards Preview

Unit 6: Pathology > Liver - Jaundice > Flashcards

Flashcards in Liver - Jaundice Deck (18)
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1
Q

What is the earliest sign of jaundice?

A

scleral icterus

2
Q

What specifically makes stool brown and urine yellow?

A

urobilinogen

3
Q

What happens to cause jaundice in extravascular hemolysis or ineffective erythropoeisis?

A

high levels of UCB overwhelm ability of liver to conjugate

4
Q

What are the clinical manifestations of extravascular hemolysis/ineffective erythropoeisis?

A

dark urine - inc urobillinogen!

- inc risk for bilirubin gallstones due to inc UCB

5
Q

Why does an ittybitty new baby get yellow?

A

transient low UGT activity

6
Q

What are two reasons why premature infants are more susceptible to becoming bananna colored?

A

hepatic clearance less developed

turnover RBCs is more pronounced

7
Q

in all seriousness, why is jaundice in a baby dangerous?

A

UCB is fat soluble and can deposit in BG

  • kernicterus
  • can lead to neuro deficits and death
8
Q

Whats the treatment for the sunshine colored babies

A

phototherapy

9
Q

What is gilbert syndrome?

A

mildly low UGT activity

10
Q

What are the clinical manifestations of gilbert?

A

jaundice during stress

11
Q

What is crigler naijar?

A

EVIL VILLAIN that STOLE THE UGT

absent UGT

12
Q

What is dubin johnson syndrome?

A

deficiency of bilirubin canalicular transport protein

-impaired transport into canaliculus

13
Q

What is the pathology of dubin johnson syndrome?

A

black liver but no other problems -

no bitches no problemz (think that dubin johnson sounds like a black NBA supastar)

14
Q

What are some things that can cause obstructive jaundice?

A
  1. gallstones
  2. pancreatic carcinoma
  3. cholangiocarcinoma
  4. parasites
  5. liver fluke
15
Q

What are some physical symptoms of biliary tract obstruction besides jaundice?

A
pruiritus - inc bile acids in skin
xanthomas - hypercholesterolemia
steatorrhea
malabsorption of fat soluble vitamins
dark urine
16
Q

What is the pathological appearance of billiary duct obstruction?

A

liver is swollen and bile stains

  • feathery degeneration
    1. hydropic swelling
    2. bile pigment
    3. reticulated
17
Q

Which causes of jaundice cause inc UCB?

A

Neonatal jaundice
Gilbert and crijjar
Hemolysis and ineffective hematopoiesis
Viral hepatitis and cirrhosis -mixed

18
Q

What causes CB jaundice

A

Biliary tract obstruction
Primary sclerosing cholangitis
Primary biliary cirrhosis
Hepatitis and cirrhosis - mixed