ID: DNA Viruses Flashcards Preview

Unit 6: Pathology > ID: DNA Viruses > Flashcards

Flashcards in ID: DNA Viruses Deck (17)
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1
Q

What is the pathognomonic feature of Herpes viruses on microscopy?

A

intranuclear inclusion bodies

2
Q

Name the latency:

  1. VZV
  2. HSV1
  3. HSV2
  4. EBV
  5. CMV
A
  1. DRG
  2. Trigem
  3. Sacral ganglia
  4. B cells
  5. Mononuclear cells
3
Q

Describe the rash in chickenpox

A

asynchronous rash - crops of vesicles

4
Q

Describe the rash in shingles

A

vesicles on one dermatome

5
Q

Describe the rash in HSV1

A

dew drops on a rose

6
Q

What is the number one cause of meningoencephalitis in the US?

A

HSV1 infection

7
Q

If a mom is pregnant and has HSV2 infection, what does she put her baby at risk for?

A

disseminated HSV2 infection in the newborn with liver involvement and can cause meningoencephalitis

8
Q

Where are the lesions located in meningoencephalitis infection with HSV1?

A

temporal lobe

KNOWW DISS

9
Q

What cells does EBV infect?

A

nasopharyngeal and B cells - both have CD21

10
Q

What cells are pathognomonic for EBV infection?

A

atypical lymphocytes - have vacuolated cytoplasm

-T cells are activated to kill the mitogenic infected B cells

11
Q

Name five diseases EBV can cause besides mono and where/in who do they occur

A
  1. lymphoproliferative disorders - IC
  2. hairy oral leukoplakia - IC
  3. Burkitts lymphoma - Africa
  4. Hodkins lymphoma
  5. Nasopharyngeal - Asia
12
Q

How do you diagnose EBV infection

A

heterophile + antibody test

13
Q

What is pathognomonic for CMV infection?

A

owls eye inclusion

14
Q

What is the classic infection that CMV causes in a neonate?

A

“blueberry muffin baby” - TTP and widespread necrosis

15
Q

What do you worry about with CMV + transplants?

A

reactivation and interstitial pneumonitis in transplant patients

16
Q

Name the most common serotypes of HPV that cause:

a) common warts
b) condyloma accuminatum
c) squamous cell carcinoma

A

a) 1, 2, 4
b) 6, 11
c) 16, 18

17
Q

What happens cellularly to cause squamous carcinoma

A

E6 inhibits P53 and E7 inhibits RB