ID: DNA Viruses Flashcards Preview

Unit 6: Pathology > ID: DNA Viruses > Flashcards

Flashcards in ID: DNA Viruses Deck (17):
1

What is the pathognomonic feature of Herpes viruses on microscopy?

intranuclear inclusion bodies

2

Name the latency:
1. VZV
2. HSV1
3. HSV2
4. EBV
5. CMV

1. DRG
2. Trigem
3. Sacral ganglia
4. B cells
5. Mononuclear cells

3

Describe the rash in chickenpox

asynchronous rash - crops of vesicles

4

Describe the rash in shingles

vesicles on one dermatome

5

Describe the rash in HSV1

dew drops on a rose

6

What is the number one cause of meningoencephalitis in the US?

HSV1 infection

7

If a mom is pregnant and has HSV2 infection, what does she put her baby at risk for?

disseminated HSV2 infection in the newborn with liver involvement and can cause meningoencephalitis

8

Where are the lesions located in meningoencephalitis infection with HSV1?

temporal lobe
KNOWW DISS

9

What cells does EBV infect?

nasopharyngeal and B cells - both have CD21

10

What cells are pathognomonic for EBV infection?

atypical lymphocytes - have vacuolated cytoplasm

-T cells are activated to kill the mitogenic infected B cells

11

Name five diseases EBV can cause besides mono and where/in who do they occur

1. lymphoproliferative disorders - IC
2. hairy oral leukoplakia - IC
3. Burkitts lymphoma - Africa
4. Hodkins lymphoma
5. Nasopharyngeal - Asia

12

How do you diagnose EBV infection

heterophile + antibody test

13

What is pathognomonic for CMV infection?

owls eye inclusion

14

What is the classic infection that CMV causes in a neonate?

"blueberry muffin baby" - TTP and widespread necrosis

15

What do you worry about with CMV + transplants?

reactivation and interstitial pneumonitis in transplant patients

16

Name the most common serotypes of HPV that cause:
a) common warts
b) condyloma accuminatum
c) squamous cell carcinoma

a) 1, 2, 4
b) 6, 11
c) 16, 18

17

What happens cellularly to cause squamous carcinoma

E6 inhibits P53 and E7 inhibits RB