IPC final exam - communication Flashcards
Anticonvulsants
What are some MOAs
does t have a lot of a few indications and what are they?
MOAs
GABA (inhibitory neurotransmitter)
Ion channels (Na+, Cl-, Ca++)
Unknown
Many indications
Seizures
Migraine prophylaxis
Bipolar disorders
Weight loss
Neuropathic pain
what are the anticonvulsants
carbamazepine
Seizures are curbed
We are amazed that seizures are controlled
oxcarbazepine
Similar to carbamazepine (structural analog)
Drug interactions, MOA
Tegretol is first alphabetically, then Trileptal
Newer agent has clinical benefits
Trileptal epilepsy
Keppra
levetriacetam
Elevate seizure threshold?
No – but prevents seizures
Dilantin
phenytoin
Dilantin rhymes with “shakin’?
Lamictal
lamotrigine
Limo have shocks to prevent excessive shaking
-trigine trigger causes rash (SJS)
-motrigine no trigger does not trigger seizures (prevents)
Topamax
topiramate
Depakote
valproic acid, divalproex sodium
val vul convulsions
proex: professional at extracting seizures
kote coat protection from seizures
Neurontin and Lyrica
gabapentin and pregabalin
GABA
what is the cause of parkinson’s
what are the 2 meds for it
Neurodegenerative
Lack of dopamine
Movement issues
Chronic, progressive
Cogentin
benztropine
Anticholinergic
atropine cholinergic
Cog cog-wheel rigidity
Requip, Requip XL
ropinirole
Dopamine agonist
Rope & roll
reign in your movement
Pin & roll
pill rolling (tremor)
what anticonvulsant is used for migraines
Imitrex
sumatriptan
Serotonin Receptor Agonist
-triptans
Summa cum laude
Get rid of the migraine and you’ll be able to study and focus
Im available in other formulations for severe migraine
But NOT IM!
SC and nasal (and PO)
Imitates serotonin?
Trips up migraines?
what meds help with RA
Plaquenil
hydroxychloroquine
RA and lupus
Antimalarial
Anti-Covid?
Chronic inflammation with RA plaques in arteries
Trexall
methotrexate
RA and cancers
T-Rex + all + ate
T-Rex ate it all!
Pain & inflammation
All formulations
PO
IM, SC, IV
Intrathecal
What meds help with Parkinson’s Disease
Neurodegenerative
Lack of dopamine
Movement issues
Chronic, progressive
Cogentin
benztropine
Anticholinergic
atropine cholinergic
Cog cog-wheel rigidity
Requip, Requip XL
ropinirole
Dopamine agonist
Rope & roll
reign in your movement
Pin & roll
pill rolling (tremor)
what meds help with Psoriasis / inflammatory skin conditions
Kenalog
triamcinolone
Tri 3 indications
Psoriasis
Inflammatory skin conditions
Pruritus
-olone alone
Commercials about psoriasis show people wanting to be alone
Temovate
clobetasol
vate alleviate itching
Vacate itching
clob clobber itching
what are the types of pain
somatic pain
- musculoskeletal
- dull/achy/surgical
- local
visceral pain
- internal organs
- pressure/squeezing
- diffuse
neuropathic pain
- nerve pain
- burning, shooting, stabbing, stinging
- waves of frequency and intensity
- diffuse
what are non-pharm. treatments for pain
Rest
Ice
Compression
Elevation
RICE!
what adjuvants are good for neuropathic pain
Anticonvulsants
SSRI/SNRIs
TCAs
Good for neuropathic component of pain
what are NSAID MOA, ADRs & clinical pearls
MOA: mode of activity
Inhibit Cyclooxygenase (COX) mediated prostaglandin synthesis
Decrease immune response
Decrease inflammation, fever, pain
ADRs
GI upset/ulcers
Bleeding
Edema
Hypertension
Clinical Pearls
Take with food
Can cause kidney issues
Increased risk of MI/stroke
NSAIDs – Pregnancy and Children caution
Chronic use in women of childbearing age: linked to reversible infertility
DO NOT give during 3rd trimester
Premature closure of the ductus arteriosus and other effects
Consult with OBGYN before taking in 1st or 2nd trimester
DO NOT give to children <6 months
Other classes:
APAP: Safe in pregnancy and children of any age (Rx)
Opioids: Able to be used in pregnancy and children at any age but not preferred due to risk of addiction and neonatal withdrawal
NSAIDs memory devices
“-profen” & “-proxen”
Advil, Motrin
ibuprofen
Aleve, Naprosyn, Naprelan
naproxen
Alleviate pain
Mobic
meloxicam
Voltaren, Zipsor, Flector
diclofenac
Voltage decrease conduction of pain
Flec on your skin (patch)
Celebrex
Celecoxib
Celebrate pain relief!
Cox COX-2 selective
Opioids MOA, ADRs & clinical pearls
MOA
Mu (μ) receptor agonist
Analgesic, antitussive, antidiarrheal
Not anti-inflammatory
Clinical Pearls
Opioid epidemic
Scheduled/controlled
Take with bowel regimen
ADRs
Common:
Pruritus (up to 80% for morphine)
Constipation, N/V
Dizziness, HA, Lightheadedness, drowsiness/somnolence
Miosis
Urinary retention
Serious:
Respiratory depression
CNS depression
Dependence
which opioid is the most potent
fentanyl!
what are meds that are Opioid Analgesics
Duragesic (CII)
fentanyl
“fent can kill” super potent, current killer
Used for sedation and general anesthesia (“vent” ventilator)
MS Contin, Kadian, Duramorph (CII)
morphine sulfate (MS)
cont continuous (lasts 8-12 hours)
Kadian circadian rhythm 24 hour pain relief
Roxicodone, OxyContin, Oxaydo (CII)
oxycodone
contin continuous (lasts 8-12 hours)
-codone related to codeine
Ultram (CIV)
tramadol
tram wreck (not as strong as a train wreck)
Opioid Analgesic / APAP Combinations
Tylenol with codeine (CIII)
APAP with codeine
#3: 300 mg APAP, 30 mg codeine
#4: 300 mg APAP, 60 mg codeine
Percocet, Roxicet, Endocet (CII)
oxycodone with APAP
-cet acetaminophen
oxy oxygen group (breathe easier with pain relief?)
Vicodin, Norco (CII)
hydrocodone with APAP
-codin -codone related to codeine
hydro hydrogen group (relax, like floating in water?)
Other pain medications
Methadose, Dolophine (CII)
methadone
For pain or opioid use disorder (opioid analgesic)
done done using opioids or done with cancer pain
This is the method to stop using opioids
Suboxone (CIII)
buprenorphine and naloxone
For opioid use disorder (opioid partial agonist and antagonist)
Sub- sublingual, or substitute for opioids
Lidoderm Patch
lidocaine
For pain (Topical analgesic/anesthetic)
-derm topical / applied to skin
-caine anesthetic (benzocaine, cocaine)
Muscle relaxants
Flexeril
cyclobenzaprine
Improve flexibility, you can cycle and bend!
Robaxin
methocarbamol
Relaxin with Robaxin
Soma
carisoprodol
Zanaflex
tizanidine
Improve flexibility
Gablofen, Lioresal
baclofen
Similar sounds
“-fen” might imply NSAID (be careful)
what are Corticosteroids
Used for inflammatory conditions (asthma, urticaria, severe allergic reactions, gout, IBD, etc.)
“-sone” or “-solone”
Orapred, Millipred, Pediapred
prednisolone
In liquid form for pediatric patients
Deltasone
prednisone
Medrol
methylprednisolone
Dose pack: 6-5-4-3-2-1
TCAs – Tricyclic Antidepressants
what is t used for
what does it cause you to do
Used for:
Depression
Neuropathic pain
Migraine prophylaxis/prevention
Elavil
amitriptyline
Pamelor
nortriptyline
“-triptyline”
“tri” Tricyclic antidepressant
Sedating could make you dizzy, careful not to trip
SSRIs – Selective Serotonin Reuptake Inhibitor
what is it used for
Used for depression and anxiety
Celexa
citalopram
Sounds like “relax”
Lexapro
escitalopram
Celexa, but like a professional
Zoloft
sertraline
Loft lift up, lift your mood
Paxil
paroxetine
Packs ill feelings
Prozac
fluoxetine
Pro + Zac hard sounds, strong antidepressant
Careful with “-oxetine”
Atomoxetine and duloxetine are not SSRIs
SNRIs – Serotonin Norepinephrine Reuptake Inhibitor
what is it used for
Used for depression
Some also used for fibromyalgia, anxiety disorders, narcolepsy, etc.
Cymbalta
duloxetine
du- Dual action w/ serotonin and norepinephrine
Playing the cymbals makes you happy
Effexor XR
venlafaxine
Pristiq
desvenlafaxine
Newer agent, must be prestigious, pristine
Depression and Smoking Cessation
Desyrel
trazodone
Serotonin Reuptake inhibitor
Used for depression and sleep
-azodone alone only works on serotonin
Remeron
mirtazapine
Remember, only one
no real pharmacologic category, it’s just an antidepressant
Wellbutrin, Zyban
bupropion
Be well, no butts
I ban smoking
Wellbutrin TID
Wellbutrin SR BID
And Zyban
Wellbutrin XL once daily
Chantix
varenicline
My chant is “I’m very inclined to quit”