Jax Handbook - Chap 7 Animal Health: Preventing, Identifying, and Eradicating Microbial Contamination Flashcards Preview

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Flashcards in Jax Handbook - Chap 7 Animal Health: Preventing, Identifying, and Eradicating Microbial Contamination Deck (21)
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1

Name two important consequences of microbial contamination.

Development of clinical disease; Physical/Physiological changes that confound research results

2

Most facilities agree that which of the following organisms should be excluded:
a. Helicobacter spp.
b. Pinworms
c. Mouse adenovirus
d. Pneumocystis murina

c. Mouse adenovirus

3

True or False: Although elimination of all microorganisms is desired, cost and resources may prohibit implementation

False

4

Which of the following is not an element of an animal health program
a. exclusion list
b. inclusion list
c. preventive measures
d. eradication procedures

b. inclusion list

5

In the case of an outbreak, it is essential for...
a. suppliers to notify institutions to whom they distribute
b. researchers to disclose the outbreak to publishers
c. facilities to potentially restrict movement of animals
d. veterinarians to wear additional PPE

a. suppliers to notify institutions to whom they distribute

c. facilities to potentially restrict movement of animals

6

Which of the following is a good reason to include a microorganism on your exclusion list?
a.  Most facilities have this microorganism on their exclusion list
b.  The test for this microorganism is inexpensive
c.  There is zoonotic potential
d.  It causes opportunistic infections

c.  There is zoonotic potential

7

True or False: The same microorganisms should be excluded from all facilities within an institution

False

8

True or False: You should be prepared to implement appropriate measures to eradicate a microorganism if it is included on your exclusion list.

True

9

What are six important aspects to maintaining a physical barrier facility?

  1. Define procedures for entering
  2. Develop procedures for animal work
  3. Document procedures and requirements
  4. Distribute procedures and requirements
  5. Train personnel
  6. Make documentation regarding proper procedures readily available

10

Traffic routes for equipment and supplies are important to.....
a.  Prevent collisions between personnel
b.  Avoid contact between clean and dirty materials
c. Help people find their way around the facility
d.  Monitor inventory

b.  Avoid contact between clean and dirty materials

11

What are three methods of introducing mice into your facility?

  1. Rederivation
  2. Quarantine
  3. Move directly into colony

12

An advantage regarding the use of colony animals for monitoring disease is....
a. They are less expensive to obtain
b. They have the same susceptibility as research animals
c. They will always have a serological response to pathogens
d. They are free from most pathogens

b. They have the same susceptibility as research animals

13

What are two types of sentinel mice?

Dirty bedding sentinels

Cage contact sentinels

14

All of the following are disadvantage of dirty bedding sentinels, EXCEPT....
a.  Reduced serological response to antigens
b. Poor transmission of aerosolized organisms
c. Slow spread of some microorganisms to sentinels
d.  Sentinels may be the source of pathogens

a.  Reduced serological response to antigens

15

True or False: False positives are more common with IFA than ELISA.

False

False positives are more common with ELISA, but can occur with both techniques

16

True or False: Microbiologic culture detects most bacteria.

True

17

True or False: PCR does not yield false positive results

False

18

What would a technician notice in a mouse that might indicate the presence of infectious disease?

Poor haircoat

Emaciation

High neonatal mortality

Runted weanlings

19

When a positive ELISA result is found, the best strategy is to:
a. Immediately implement eradication strategies
b. Retest with 10 more mice
c.  Retest using an IFA test
d. Determine the prevalence in the colony

c.  Retest using an IFA test

20

The use of burnout is a good strategy when:
a.  The mice are immunodeficient or immunocompromised
b. An agent spreads slowly through a populations
c.  Maintaining a breeding colony
d. The agent elicits a lifelong immunity

d. The agent elicits a lifelong immunity

21

What is the best insurance against loss of valuable strains?

Cryopreservation