Flashcards in L74 Deck (53)
Who is most likely to get chicken pox complications?
IC pts: newborns, pregnant, transplant, AIDs
Complications of chicken pox
Reye's syndrome - aka don't give aspirin to kids!!!
Hallmarks of Shingles rash
Stops at midline
If CN 5 involvement --> encephalitis
What is the Shingles complication if there is geniculate ganglion involvement?
Ramsey Hunt Syndrome
- 1 sided facial palsy
- Lesions in ear
- Loss taste ant 2/3 tongue
Immune response to VZV
IgM + IgG - limit spread
CD4 - resolve rash
You're probably diagnosing CP/Shingles clinically, but if you really wanted to what test would you order?
Pap smear of a lesion
Direct fluorescent Ab
PCR of CSF if neuro involvment
What is the chicken pox vaccine?
Prevents chicken pox in kids & decreases shingles in elderly
Which vaccine do you give to IC pts?
VZIG = immunoglobulin
Ex: pregnant women who have been exposed to chicken pox
Babies whose mothers have chicken pox
When and how do you treat chicken pox?
24 hrs of 1st lesion: PO acyclovir
How do you treat IC pts with chicken pox?
When and how do you treat Shingles in normal pts?
72hrs of 1st lesion: 7 day course of PO
Which shingles complication/presentation should you always treat?
How do you treat shingles in IC pts?
Goal: decrease severity + speed healing
When does HHV 6 infection occur in life in comparison to CMV and EBV?
Earlier in life!
Which skin disease is most common in kids due to HHV6?
Roseola = exanthem subitum
2. Red, raised rash w/o fever
Which conditions would clue you into an HHV 6 infection in kids AND adults?
Seizures in kids
Delayed bone marrow grafts in bone marrow transplant pts
DRESS syndrome = drug rxn eosinophila w/ systemic symptoms
Diagnose HHV6 infection.
Serology: IgM & IgG
What 3 characteristics are unique about HHV8?
1. Tumor promoting genes
2. Lympho AND angiotrophic
3. Has proteins homologous to cell proteins
Which tissues does HHV8 infect?
Uro & GI epithelium
How does HHV8 lie latent?
Episome - contributes to oncogenic reactivation
Where in the world are HHV8 infections most prevalent?
Mediterranean + Africa