Lab 5 Renal Flashcards Preview

Pathology 372 > Lab 5 Renal > Flashcards

Flashcards in Lab 5 Renal Deck (15):
1

This is tissue from a 6-year old foal with a heart murmur.  Describe the lesion:

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Large, multifocal, well demarcated, wedge-shaped to irregular-shaped areas of tannish discoloration (necrosis).  These areas are bordered by a narrow zone of dark red (hemorrhage) extending from the cortex to the corticomedullary junction.  Abnormal areas measure 1.5 by 1.5 cm up to 5 cm in diameter.  Lesions are slightly softer in consistency than the normal tissue.

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2

  1. Give a morphologic diagnosis for these lesions:

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  1. Kideny: Multifocal, acute, renal infarcts

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3

The lesions observed in this kidney have been caused by occlusions within one or more arterial vessels.  What are 2 conditions that could have predisposed this animal to an arterial vascular occlusion?  

Background information: this was a 6 year old foal with a heart murmur.

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  1. Septicemia 
  2. Endocarditis of the left AV valve 

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4

The 2 conditions in bold below can lead to development of an arterial vascular occlusion; what are the missing steps involved in these processes?

Septicemia -> ___ -> ___ -> ___ -> Infarction

Endocarditis -> ___ -> ___ -> Infarction

  1. Septicemia -> Endothelial cell damage -> Heightend state of coagulation -> Thrombus formation -> Infarction
  2. Endocarditis of the left AV valve -> Produces emboli -> Emboli lodge into renal arteries -> Infarction

5

This is tissue from a 12-year old feline.  

  1. Describe the lesion.
  2. Give a morphologic diagnosis.

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  1. The kidneys are bilaterally swollen/enlarged.  Multifocally raised nodules extend from the cortex into the cut surface.  The nodules are pale, firm, and about 1 - 1.5 cm in diameter.
  2. Kidney: Multifocal, chronic, nodular nephropathy

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6

List two possible differential diagnoses for the enlarged, pale kidneys in the following case:

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  • Neoplasia (renal lymphoma)
  • Inflammation associated with infection (FIP)

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7

This is tissue from a 7 month old male foal.  The foal was anorectic.

  1. Describe the lesions.
  2. Give a morphologic diagnosis.

 

 

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  1. Liver is diffusely enlarged, pale to yellow in color, and friable with rounded edges.  The kidney has a diffusely expanded cortex, which is also markedly pale.
  2. Kidney, liver: Diffuse hepatic and renal lipidosis 

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8

What might be some possible causes of hepatic and/or renal lipidosis, as in the picture here?

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  1. Mobilization of lipid secondary to anorexia
  2. Hypoxia
  3. Protein deficiency

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9

This is tissue from a 4 year old ewe with a history of weight loss and enlarged prescapular lymph nodes.

  1. Describe the lesion.
  2. Give a morphologic diagnosis.

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  1. Multifocally, the renal cortex and corticomedullary junction contain encapsulated, round nodules that are about 2 - 3 cm in diameter.  These nodules contain a creamy tan semifluid material.
  2. Kidney: multifocal, chronic, renal abscesses

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10

This is tissue from a 1 year old male feline with chronic diarrhea, weight loss, and lethargy.

  1. Describe the lesion.
  2. Give a morphologic diagnosis.

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  1. The cortical surface of the kidney contains multifocal to coalescing small, yellow, nodular areas about 1 cm in diameter.  The areas extend into the cut surface, affecting the cortex, corticomedullary junction, and the medulla.
  2. Kidney: Multifocal, chronic, nodular nephropathy

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11

List 3 possible differential diagnoses associated with a nodular nephropathy as displayed here:

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  1. Feline infectious peritonitis (FIP)
  2. Lymphoma
  3. Toxoplasmosis

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12

This is a tissue from a 1 year old, castrated male Persian cat with recent weight loss, lethargy, anorexia.  He was moderately to severely dehydrated on presentation.

  1. Describe the lesion.
  2. Give a morphologic diagnosis.

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  1. The kidneys are bilaterally enlarged.  Multifocally throughout the parenchyma of the kidneys are numerous cystic structures, ranging in size from 0.5 - 1.5 cm in diameter.  Theses cystic areas also buldge from the capsular surface and on cut surface.
  2. Kidney: Multifocal, bilateral, renal cysts (polycystic kidneys)

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13

This is tissue from a 1 year old cat.  Why might these lesions be congenital as opposed to acquired?

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These are LARGE cysts in a YOUNG cat, both of which suggest a congenital defect.  Acquired cysts are generally FEWER and SMALLER in size.

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14

As opposed to a congenital polycystic kidney, what kind of changes within the kidney might lead to an acquired polycystic kidney? 

Injury to a tubule segment -> Focal weakness within that tubule --> Dilation of that tubule

(Often secondary to renal interstitial fibrosis)

 

15

List 2 physical differences between congenital renal cysts and acquired renal cysts that may help you differentiate between the two grossly.

  • Acquired: often 1 focal "weak spot" 
  • Congenital: often multiple cysts
  • Acquired: small cysts
  • Congenital: large cysts