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Flashcards in Renal test review Deck (10):

  1. What is your diagnosis of this kidney?
  2. What are the defining features of this condition?
  3. What causes this young animal to develop CRF?

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  1. Renal fibrosis secondary to renal dysplasia & glomerular hypoplasia
    • Thin/irregular cortex
    • Thickened capsule
    • Abundant fibrosis tissue in the interstitium
    • Underdeveloped glomeruli ("FETAL GLOMERULI")
  3. With the loss of nephrons, remaining nephrons become sclerotic and disfunctional as well.  With the loss of more and more nephrons, TGFR decreases and azotemia will develop.

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  1. What has caused these changes within this nephron?
  2. List all the abnormalities:

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  1. Increased demand on the nephron
    • Enlarged glomerulus
    • Increased urine space
    • Dilated tubules
    • Dilated renal corpuscle

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  1. What cell type is depicted next to the arrow?
  2. What are the brown color changes associated with?
  3. What disease process is this?

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  1. Podocytes (hypertrophied)
  2. Thickened basement membrane
  3. Glomerulonephritis

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Thrombosis is a risk factor or glomerular dysfunction.  What 2 specific clincal disease conditions put an animal at risk of developing thombi?

  1. Amyloidosis
  2. Nephrotic syndrome


  1. What is your morphologic diagnosis?
  2. What 3 changes does this lead to (these changes are a pathway to one another as well?

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  1. Renal amyloidosis; amyloid in the glomeruli
    • Glomerular dysfunction
    • Proteinuria (leaks protein because the filtration membrane is messed up)
    • Nephrotic syndrom


Membranoproliferative GN can be found on which side of the filtration membrane?



  1. What disease process has taken over this horse kidney?
  2. What are 3 consequencees of this condition?

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  1. Glomerulonephritis (notice granularity)
    • Nephrotic syndrome
    • Thombosis
    • CRF with chronic GN


How can glomerulonephritis lead to this?

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This is subcutaneous edema.  GN causes a damage to the glomeruli and hence the glomerular filtration apparatus.  This animal will develop proteinemia and hypoalbuminemia as a result of the glomerular injury.  With decreased protein in circulation, oncotic pressure decreases and fluid leaks into the subcuticular space.


What type of necrosis is renal crest necrosis?



What is your diagnosis?

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Vasculocentric nephritis