Flashcards in Lec 18 Fever in the Immunocompromised Host Deck (20)
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1
dirtiest areas in our bodies
mouth and large intestine
2
cytotoxic agent that affects VEGF
bevacizumab
3
febrile neutropenia criteria
Fever of >38.30C OR sustained fever ≥ 380C for 1 hour or more
AND
Absolute neutrophil count
4
cytotoxic agent that affects EGFR
cetuximab
5
cytotoxic agent that affects CD33
gemtuzumab
6
cytotoxic agent that affects HER2
trastuzumab
7
Prevention for high-risk patients with expected durations of prolonged and profound neutropenia (Absolute Neutrophil Count
Fluoroquinolone Prophylaxis
8
Prevention for those undergoing allogenic stem cell transplant and For those undergoing remission-induction or salvage induction chemotherapy for acute leukemia
Anti-Candida Prophylaxis
9
Prevention for those undergoing extensive chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome
Posaconazole Prophylaxis
10
Prevention for herpes simplex virus (HSV)-positive patients undergoing allogenic stem cell transplant or leukemia induction therapy
Acyclovir Prophylaxis
11
leading cause of cell-mediated immunity suppression
HIV
12
Requires the least amount of immunosuppression among all transplant organs
kidney transplant
ps. pag nakarating ka na dito, pakyu ka
13
Requires the highest amount of immunosuppression among all transplant organs
heart and intestines
14
First-line immunosuppressants
Calcineurin Inhibitors and Anti-proliferative agents
15
Immunosuppression peaks during the first ____ months post-transplant
6
16
Used for autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis.
TNF agonists
17
targets CD20 found in B cells
rituximab
18
Why does DM cause increased infection?
1. hyperglycemia effects
2. Breaks in cutaneous and mucosal barrier due to microvascular angiopathy
3. Neuropathy which diminishes pain sensation
19
Immune changes as we get older
1. Functional change in T cell subsets, with a decrease in IL-2 secretion
2. Naive T cells have decreased ability to respond to new antigens
3. Humoral immunity mildly affected
20
