Lec 18 Fever in the Immunocompromised Host Flashcards Preview

OS 217 Infectious Diseases > Lec 18 Fever in the Immunocompromised Host > Flashcards

Flashcards in Lec 18 Fever in the Immunocompromised Host Deck (20)
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1

dirtiest areas in our bodies

mouth and large intestine

2

cytotoxic agent that affects VEGF

bevacizumab

3

febrile neutropenia criteria

Fever of >38.30C OR sustained fever ≥ 380C for 1 hour or more

AND

Absolute neutrophil count

4

cytotoxic agent that affects EGFR

cetuximab

5

cytotoxic agent that affects CD33

gemtuzumab

6

cytotoxic agent that affects HER2

trastuzumab

7

Prevention for high-risk patients with expected durations of prolonged and profound neutropenia (Absolute Neutrophil Count

Fluoroquinolone Prophylaxis

8

Prevention for those undergoing allogenic stem cell transplant and For those undergoing remission-induction or salvage induction chemotherapy for acute leukemia

Anti-Candida Prophylaxis

9

Prevention for those undergoing extensive chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome

Posaconazole Prophylaxis

10

Prevention for herpes simplex virus (HSV)-positive patients undergoing allogenic stem cell transplant or leukemia induction therapy

Acyclovir Prophylaxis

11

leading cause of cell-mediated immunity suppression

HIV

12

Requires the least amount of immunosuppression among all transplant organs

kidney transplant

ps. pag nakarating ka na dito, pakyu ka

13

Requires the highest amount of immunosuppression among all transplant organs

heart and intestines

14

First-line immunosuppressants

Calcineurin Inhibitors and Anti-proliferative agents

15

Immunosuppression peaks during the first ____ months post-transplant

6

16

Used for autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and psoriasis.

TNF agonists

17

targets CD20 found in B cells

rituximab

18

Why does DM cause increased infection?

1. hyperglycemia effects
2. Breaks in cutaneous and mucosal barrier due to microvascular angiopathy
3. Neuropathy which diminishes pain sensation

19

Immune changes as we get older

1. Functional change in T cell subsets, with a decrease in IL-2 secretion
2. Naive T cells have decreased ability to respond to new antigens
3. Humoral immunity mildly affected

20

Which of these can cause impairments in antibody-mediated immunity?
A. Multiple myeloma
B. Chronic lymphocytic leukemia
C. Splenectomy
D. Rituximab treatment
E. AOTA

E