Lec 19 Animal Bites and Rabies Flashcards Preview

OS 217 Infectious Diseases > Lec 19 Animal Bites and Rabies > Flashcards

Flashcards in Lec 19 Animal Bites and Rabies Deck (30)
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1

Antibiotic therapy for bitten patients:

Treat bitten patient with a combination of B-lactams and B-lactamase inhibitors

2

5 proteins encoded by rabies virus

N, NS, M, G, L

3

Major influencing factors in the incubation period of Rabies.

- Virus load
- Virus strain
- Severity of exposure (multiple bites, size &
depth of bite)
- Localization of exposure (the site of inoculation: the nearer to the brain, the shorter incubation period)

4

Non-specific symptoms of malaise, fatigue, headache, fever, nausea and vomiting, non-productive cough, anorexia, sore throat and paresthesia are experienced during which phase of RABIES?

Prodrome phase

5

Identify Clinical Manifestation Phase of RABIES:
· Excessive motor activity
· Excitation and agitation
· Confusion, hallucination, combativeness
· Bizarre aberration of thought, muscle spasms

Encephalic Phase

6

Identify Clinical Manifestation Phase of RABIES:
Hydrophobia

Brainstem Dysfunction Phase

7

Identify Clinical Manifestation Phase of RABIES:
Cranial nerve involvement
Respiratory center involvement

Brainstem Dysfunction Phase

8

Median survival period after onset of symptoms of Rabies.

4-20 days

9

Causes of death in Rabies patients

coma and apnea

10

The first rabies specific symptom

pain or paresthesia

11

Late complications of Rabies infection include:
a. SIADH
b. cardiac arrhythmia,
c. ARDS,
d. thrombocytopenia,
e. NOTA
f. AOTA

f. AOTA
Others:
diabetes insipidus, vascular instability, UGIB, Paralytic Ileus

12

Encephalitic vs Paralytic Rabies:
Fluctuating consciousness

Encephalitic

13

Encephalitic vs Paralytic Rabies:
Autonomic dysfunction

Encephalitic

14

Encephalitic vs Paralytic Rabies:
80% of Rabies cases

Encephalitic

15

Encephalitic vs Paralytic Rabies:
Complete paralysis and Guillain-Barre like symptoms

Paralytic

16

Cytoplasmic inclusion bodies in the brain tissue of Rabies patients.

Negri bodies

17

Gold standard for the diagnosis of Rabies

4-fold rise in titer of neutralizing antibodies in serial dilution

18

Done for viral antigen if brain tissue is available for diagnostic workup.

Direct fluorescent antibody (FA) staining

19

Done for viral isolation if brain tissue is available for diagnostic workup.

Mouse inoculation

20

WBC count of rabies patients
a. Very high
b. normal
c. slightly elevated
d. AOTA

d. AOTA

21

Identify category of exposure to Rabies virus:
- Feeding/touching an animal
- Licking of intact skin

Category 1

22

Identify category of exposure to Rabies virus:
Minor scratches

Category 2

a. Nibbling/nipping of uncovered skin w/ bruising
b. Minor scratches / abrasions without bleeding*
c. Licks on broken skin
*include wounds that are induced to bleed

23

T/F: Death can still be avoided once Prodrome Phase of Rabies begins

F. Death is inevitable

24

The first step of post-exposure treatment for rabies

Local wound care/treatment

25

Identify category of exposure to Rabies virus:
Minor scratches on head and neck area

Category 3

26

Identify category of exposure to Rabies virus:
Start vaccine and RIG (preformed antibody) immediately

Category 3

27

Identify category of exposure to Rabies virus:
Contamination of mucous membrane with saliva (i.e. licks)

Category 3

28

After administration on wound site, remaining RIG should be injected on the:

anterolateral thigh

29

Administration of intradermal PVRV/PCECV pre-exposure prophylaxis is done on days 0, ___, ___ and ____

7, 21 and 28 at 0.1ml at site

30

Continent with the greatest incidence of Rabies

ASIA