Lec 14 Leptospirosis Flashcards Preview

OS 217 Infectious Diseases > Lec 14 Leptospirosis > Flashcards

Flashcards in Lec 14 Leptospirosis Deck (16)
Loading flashcards...
1

Most important reservoir of leptospirosis

rats

2

What is the pathogenic leptospirosis species?

L. interrogans

3

What is the saprohytic lepto species?

L. biflexia

4

most important manifestations of leptospirosis

vasculitis

5

most impt known pathogenic properties of leptospires

cell surfaces and cellular toxicity

6

The major surface lipoprotein seen among pathogenic serovars

LipL32

7

First genetic susceptibility factor identified

HLA DQ6

8

WHO Criteria for Definitive Leptospirosis

a. Positive leptospiral culture of the blood and/or urine
b. High positive single lepto Microagglutination Test (MAT) titer or 1: 1600 (Phils. has higher cutoff)
c. Seroconversion from initial MAT negative to a positive antibody titer
d. Fourfold rise in antibody titers by MAT from acute to convalescent

9

Systemic reaction resembling bacterial sepsis

Jarisch Herxheimer Reactions

10

What level of exposure? single history of wading in flood or contaminated water with wounds, cuts, or open lesions of the skin OR accidental ingestion of contaminated water

moderate-risk

11

What level of exposure?single history of wading in flood or contaminated water without wounds, cuts or open lesions of the skin

low-risk

12

first sign of pulmonary leptospirosis activity?

tachypnea

13

doxycycline side effect

sunlight sensitivity, less effective OCP

14

management of AKI in leptospirosis

methylprednisolone

15

treatment for mild lepto

doxycycline

16

treatment for moderate-severe lepto

penicillin