Flashcards in Lec 14 Leptospirosis Deck (16)
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1
Most important reservoir of leptospirosis
rats
2
What is the pathogenic leptospirosis species?
L. interrogans
3
What is the saprohytic lepto species?
L. biflexia
4
most important manifestations of leptospirosis
vasculitis
5
most impt known pathogenic properties of leptospires
cell surfaces and cellular toxicity
6
The major surface lipoprotein seen among pathogenic serovars
LipL32
7
First genetic susceptibility factor identified
HLA DQ6
8
WHO Criteria for Definitive Leptospirosis
a. Positive leptospiral culture of the blood and/or urine
b. High positive single lepto Microagglutination Test (MAT) titer or 1: 1600 (Phils. has higher cutoff)
c. Seroconversion from initial MAT negative to a positive antibody titer
d. Fourfold rise in antibody titers by MAT from acute to convalescent
9
Systemic reaction resembling bacterial sepsis
Jarisch Herxheimer Reactions
10
What level of exposure? single history of wading in flood or contaminated water with wounds, cuts, or open lesions of the skin OR accidental ingestion of contaminated water
moderate-risk
11
What level of exposure?single history of wading in flood or contaminated water without wounds, cuts or open lesions of the skin
low-risk
12
first sign of pulmonary leptospirosis activity?
tachypnea
13
doxycycline side effect
sunlight sensitivity, less effective OCP
14
management of AKI in leptospirosis
methylprednisolone
15
treatment for mild lepto
doxycycline
16
