Lec 23 Grand Rounds on Sepsis Flashcards Preview

OS 217 Infectious Diseases > Lec 23 Grand Rounds on Sepsis > Flashcards

Flashcards in Lec 23 Grand Rounds on Sepsis Deck (20)
Loading flashcards...
1

Severe inflammatory syndrome that has a proven or suspected microbial etiology

Sepsis

2

Prolonged capillary refill as a criteria for severe sepsis means it is longer than how many seconds

5 seconds

3

Severe sepsis is sepsis plus which of the following?
a. Cardiovascular organ dysfunction
b. Acute respiratory distress syndrome
c. Multiple chancroids
d. AOTA
e. A & B

e. A & B

4

What is septic shock?

Sepsis plus persistent cardiovascular organ dysfunction

5

What happens to the skin of a neonate experiencing decreased delivery of oxygen and consequently hypoperfusion of organs?

Mottling

6

One evidence of inflammation is that immature to total neutrophil ratio must be:

>0.2

7

Diagnostic tests which can supply evidence for multiorgan system disease?

- Arterial blood gas analysis (metabolic acidosis and pulmonary function)
- blood chemistry
- renal function test
- hepatic function

8

Initial empiric therapy for early-onset bacterial infection in neonates:

ampicillin + aminoglycoside

9

T/F: The rational use of antibiotics in neonates involves using narrow spectrum of drugs to treat the infection and not colonization, limiting the duration of therapy

T

10

Test to distinguish neonatal pneumonia and sepsis from each other?

Blood culture

11

Presence of bacteria in blood, as evidenced by positive blood cultures

bacteremia

12

To be considered severe, sepsis must be accompanied by ____ % decrease in platelet count from highest value recorded over previous 3 days.

50%

13

Refractory septic shock is septic shock that lasts for more than:

1 hour and does not respond to fluid or pressor administration

14

stimulates leukocytes and vascular endothelial cells to release other cytokines, to express cell-surface molecules that enhance neutrophil-endothelial adhesion at sites of infection and to increase prostaglandin and leukocyte production

TNF-alpha

15

Hallmark of septic shock

decrease in peripheral vascular resistance that occurs despite increased levels of vasopressor catecholamines.

16

Definitive etiologic diagnosis in septic patients:

Isolation of the microorganism from blood or from site of infection

17

T/F: Identification of microbial DNA in peripheral blood can also be a definitive etiologic diagnostic tool for sepsis.

T

18

Empirical antimicrobial therapy must be effective against:
a. Gram positive bacteria
b. Gram negative bacteria
c. Both

C. both

19

Correct treatment against vibrio

Doxycycline + ceftazidime

20

Etiologic agent for adult case that caused characteristic bullous skin lesions, diarrhea after consumption of oysters, ever, chillls and abdominal pain:

Vibrio vulnificus