Lec 03 Principles of Vaccinology and Guidelines Flashcards Preview

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Flashcards in Lec 03 Principles of Vaccinology and Guidelines Deck (25)
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1

T/F Vaccines save lives

F. No! Vaccination does!

2

T/F Vaccines must retain pathogenicity but not antigenicity.

F. Must maintain antigenicity and not pathogenicity

3

Non-specific and the body's first line of defense

Innate Immunity

4

3 major characteristics of Adaptive Immunity

Memory, Specificity and Diversity

5

Active/Passive immunity?
Protection transferred from another person or animals
as antibody

Passive

6

Active/Passive immunity?
Usually permanent

Active

7

– substances added to inactivated vaccines
to increase host response and afford longer protection

Adjuvants

8

Live Attenuated/Inactivated?
MMR

Live attenuated

9

Live Attenuated/Inactivated?
BCG

Live attenuated (bacterial)

10

Protective immunity from inactivated vaccines develops after how many doses?

2-3

11

T/F: NO VACCINE IS COMPLETELY SAFE NOR COMPLETELY EFFECTIVE!

True

12

T/F: Simultaneous administration (administration on
the same day) of the most widely used live and inactivated vaccines doesn’t result in decreased antibody responses or increased rates of ADRs

T

13

There are NO contraindications to simultaneous administration of any vaccine except for cholera and?

Yellow fever

14

T/F: Increasing the interval between doses of a multidose
vaccine does diminishes the effectiveness of the
vaccine.

F

15

T/F: Decreasing the interval between doses of a multidose vaccine may interfere with antibody response and protection.

T

16

T/F: It is not necessary to restart the series of any vaccine
due to extended intervals between doses

T

17

Why are the buttocks not routinely used as a site for vaccination?

Possible injury to the sciatic nerve

18

Injection sites in the same limb should be separated by at least how many inches so local reactions will not overlap?

1 to 2

19

T/F If expiry date is Dec 2013, the vaccine is still viable until Dec 01, 2013.

F. Vaccine is viable until Dec 31, 2013

20

ALL vaccines are recommended to be transported and
stored at temperatures of:

2 to 8 degrees C

21

Identify severity of anaphylaxis:
Bronchospasm, stridor, collapse, hypotension, dysrhythmias

SEVERE

22

Identify severity of anaphylaxis:
Dizziness, perineal burning, warmth, pruritus

MILD

23

T/F: Tetanus vaccination of unprotected pregnant
women in developing countries is strongly recommended

T

24

Critical vaccination coverage for herd immunity (%) for Measles

92-95%

25

T/F: Inactivated vaccines are contraindicated in pregnant patients

F