Liver disease Flashcards
(16 cards)
Causes of liver disease in older child x5
Cystic fibrosis
Wilsons disease
Hepatitis B and C
Autoimmune Hepatitis
Non alcoholic fatty liver disease
Associations of non alcoholic fatty liver disease (NAFLD) x2
Obesity
Metabolic syndrome
Spectrum of NAFLD x5
Steatosis
Steatohepatitis
Fibrosis
Cirrhosis
End stage liver disease
Gold standard for Diagnosis of Wilsons disease x2
Hepatic copper seen on biopsy
Detection of gene mutation
Complications of acute liver failure x4
Sepsis
Hemorrhage
Cerebral edema
Hypoglycemia
Stabioization of patient with acute liver failure x4
Glucose >4mmol
Mannitol and fluid restriction-prevent cerebral edema
Vit K and PPI - prevents Hemorrhage
Broad spectrum antibiotics - prevention sepsis
Early signs of hepatic encephalopathy x5
Confusion
Irritability
Drowsiness
Aggressive
Difficult
Chelating agent for wilsons disease
Penicillamine
Complications of chronic liver disease x8
Malnutrition- protein energy, fat malabsorption
Cirrhosis and portal Hypertension
Fat soluble vitamin deficiency
Encephalopathy
Esophageal varices
Renal failure
Pruritus
Ascites
Fat soluble vitamins x4
A D E K
Pathological definition of cirrhosis
Extensive fibrosis with regenerative nodules
Pathophysiology effects of cirrhosis x4
Diminished hepatic function
Portal Hypertension with ascites varices and splenomegaly
Factors contributing to ascites in liver disease x4
Hypoalbuminemia
Fluid redistribution
Renal impairment
Na retention
Causes of renal failure in chronic liver disease x3
Hepatorenal syndrome
Renal tubular acidosis
Acute tubular necrosis
Chilestatic picture
Elevated GGT and ALP
Bio markers for Hep B and what they signify x5
HbS ag- current infection
HbE ag- marker of viral replication
Anti HbS- immunity, past or current infection
Core- IgM for immediate infection and IgG for past infection
