Liver Testing

Question 1

What does elevated AST and ALT represent?

Answer 1

Hepatocellular damage

Question 2

What does elevated Alkaline phosphatase represent?

Answer 2

Bile duct problems (cholestasis)

Question 3

What does elevated Gamma glutamyl transferase represent?

Answer 3

Bile duct epithelium/cannalicular membrane injury

Question 4

What cellular marker resides in mitochondria?

Answer 4

AST

Question 5

What does ETOH toxicity preferentially elevate?

Answer 5

AST

Question 6

What does a positive ANA test represent?

Answer 6

Autoimmune hepatitis

Question 7

What does a positive anti-smooth muscle antibody test represent?

Answer 7

Autoimmune hepatitis

Question 8

What does decreased ceruloplasmin represent?

Answer 8

Wilson’s disease

Question 9

What does a positive AMA-M2 represent?

Answer 9

Primary biliary cirrhosis

Question 10

Why do you do a liver biopsy?

Answer 10

Determine cause of liver disease

Determine extent of damage to the liver

Question 11

What does “Stage” mean for chronic hepatitis? What about “Grade”?

Answer 11

Stage: Degree of fibrosis
Grade: Severity of necro-inflammatory activity