LMP301 Lecture 8: Thyroid Disease Flashcards Preview

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Flashcards in LMP301 Lecture 8: Thyroid Disease Deck (82)
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31

Effect of inhibiting binding of thyroid hormones to TBG

Less T4
Same FT4

32

What compounds decrease TBG?

- androgens
- glucocorticoids

33

What compounds inhibit thyroid hormones from binding to TBG?

Salicylates

34

Myxedema

Dry, waxy swelling of the skin with abnormal deposits of glucosaminoglycans

35

Glucosaminoglycans

unbranched polysaccharides

36

What is myxedema a strong indication of?

hypothyroidism

37

key symptoms of hypothyroidism

- Weight gain
- fatigue
- myxedema
- high cholesterol
- slow HR

38

Hypothyroidism is a _____ syndrome

hypometabolic

39

What do thyroid hormones control in the body?

metabolism

40

Why is a symptom of hypothyroidisms high cholesterol?

Less LDL receptors produced, so less liver uptake

41

Types of hypothyroidism

1. Primary hypothyroidism
2. Secondary hypothyroidism
3. Tertiary hypothyroidism

42

Primary hypothyroidism

Problem at thyroid gland

43

Examples of problems at the thyroid gland

- autoimmune destruction (Hashimoto's disease)
- iodine deficiency
- treatment of hyperthyrodism
- congenital defects in hormone
- antithyroid drugs (side effect of some drug therapy)

44

Secondary hypothyroidism

Problems at pituitary gland (TSH)

45

Tertiary hypothyroidism

Problems at the hypothalamus (TRH)

46

Diagnosis for hypothyroidism:
High/normal TSH
High fT4

not hypothyroidism

47

Diagnosis for hypothyroidism:
High TSH
Low fT4

Primary hypothyroidism

48

What feature must be present for actual hypothyrodism to be diagnosed?

low fT4

49

Diagnosis for hypothyroidism:
High TSH
Normal fT4

subclinical hypothyrodism (high risk, but not yet hypo)

50

Diagnosis for hypothyroidism:
Low/normal TSH
Low fT4

Secondary hypothyrodism

51

Complications of hypothyroidism vary depending on...

When during the lifetime patient has the disease

52

Complications of hypothyroidism:
Pregnancy

Affect fetal development (irreversible)

53

Complications of hypothyroidism:
Infancy, childhood

- bad brain development
- can't grow tall
- low IQ
- bad psychomotor development
- cretinism (if severe)

54

Complications of hypothyroidism:
Adult

- death from myxedema coma (if severe)

55

Myxedema coma

- long-term hypothyrodism + another factor
- cold body (<80 F)
- loss of consciousness

56

Creatinism is ____ ___thyroidism

congenital
hypo-

57

Creatinism can be caused by...

- absence of thyroid gland
- thyroid hormone synthesis defects

58

Is creatinism fatal?

No
- Creatinism happens if diagnosed too late
- Early diagnosis can completely reverse effect

59

Symptoms of creatinism

- mental retardation
- short
- deaf
- neurological problems
- tongue sticking out
- flat nose bridge

60

How to treat creatinism?

replacement thyroid hormone