LMP301 Lecture 8: Thyroid Disease Flashcards Preview

LMP301 > LMP301 Lecture 8: Thyroid Disease > Flashcards

Flashcards in LMP301 Lecture 8: Thyroid Disease Deck (82)
Loading flashcards...
61

Diagnosis of creatinism

screening tests for newborns (can't usually tell from clinical symptoms)
- Screen TSH (should be high if T3 + T4 is low)
- High TSH = creatinism

62

Treatment for primary hypothyrodism

Replacement therapy with synthetic T3 + T4
- Monitor by observing TSH levels after a few weeks (should be normal)

63

Key symptoms of hyperthyrodism

- Weight loss
- Fatigue
- Glucose intolerance
- Tremor
- Infected eye
- Sweating
- Rapid heart rate
- High BP

64

Why is weight loss a symptom of hyperthyroidism?

Too much metabolic activity

65

Why is fatigue a symptom of hyperthyroidism? Why is it a symptom of hypothyrodism?

Hyper: high metabolic activity cause muscle overwork
Hypo: hormones not available, so no stimulation for metabolism

66

Causes of hyperthyrodism

1. Graves' disease
2. Plummer's disease
3. Thyroid tumour
4. Thyroiditis
5. Pituitary tumour
6. HCG secreting trophoblastic tumour
7. Iodine / iodine drugs
8. Excessive T4 + T3

67

Plummer's disease

toxic multinodular goiter:
excess production of thyroid hormones from functionally autonomous thyroid nodules

68

Graves' disease

Diffuse toxic hyperplasia:
- Autoimmune disease that affects the thyroid
- Antibodies bind to TSH receptor

69

Thyroiditis

inflammation of thyroid gland

70

HCG secreting trophoblastic tumour

HCG has same a-unit as TSH, so during prenancy, the excess HCG might bind to TSH receptor and stimulate T3 + T4 production

71

Why might high iodine cause hyperthyroidism

Iodine is a substrate needed to make T3 and T4

72

Symptoms of Grave's disease

- retracted eyelids

73

Diagnosis of Graves' disease

- Very low TSH
- Very high fT4
- Anti-TSH receptor antibodies
- Radionucleotide uptake and scan (will accumulate in the thyroid)

74

Treatment for Graves' disease

- Antithyroid drugs
- radioiodine / radiosodium (destroy thyroid gland)
- surgery to remove thyroid gland

75

Antithyroid drugs

- Block iodide uptake
- inhibit T4 synthesis
- inhibit T4 -> T3 conversion

76

Diagnosis for hyperthyroidism:
Normal TSH
Normal fT4

not thyrotoxicosis

77

Diagnosis for hyperthyroidism:
High / normal TSH
High fT4

Pituitary tumour
Thyroid hormone resistance syndrome

78

Diagnosis for hyperthyroidism:
Low TSH
Normal fT4
Normal fT3

subclinical thyrotoxicosis

79

Diagnosis for hyperthyroidism:
Low TSH
Normal fT4
High fT3

T3 toxicosis

80

Diagnosis for hyperthyroidism:
Low TSH
High fT4
T3 toxicosis

Primary thyrotoxicosis

81

thyrotoxicosis

hyperthyroidism

82

Why is glucose intolerance a symptom of hyperthyroidism?

Insulin is quickly cleared due to high metabolic rate