Methyl Sulfonylmethane (MSM)

Question 1

What is MSM (Methyl Sulfonylmethane) and what does it provide to the body?

Answer 1

MSM is a source of sulfur, which is used by plants to create the amino acids cysteine and methionine, both dietary sources of sulfur.

Question 2

What are the plant and animal sources of MSM?

Answer 2

Plant sources: Green leafy vegetables, alfalfa sprouts, algae, fruits, vegetables, grains.
Animal source: Milk (from cows).

Question 3

What are the therapeutic uses of MSM for osteoarthritis?

Answer 3

Reduces pain, swelling, and improves joint function when used alone or with glucosamine/chondroitin.
Anti-inflammatory properties (inhibits IL-6, TNF-α, and COX-2).
Protects cartilage due to sulfur content.
Dosage: 500 mg, three times a day.

Question 4

How does MSM support cardiovascular health?

Answer 4

Reduces homocysteine levels (via methyl donation) and lipid peroxidation.
Protects vascular endothelium.
Dosage: 3 g per day (benefits seen at 28 days).

Question 5

How does MSM aid in tissue repair?

Answer 5

Reduces oxidative stress and inflammation, aiding in GI mucosal injury repair and chronic GI inflammation.
Supports tissue healing after injury, including the skin.
Dosage: 2 g, two to three times daily.

Question 6

What role does MSM play as an immune modulator?

Answer 6

Helps with seasonal allergies by regulating the immune system and reducing inflammation.
Inhibits NF-κB activity, downregulating inflammatory cytokines.
Dosage: 2.6 g per day for seasonal allergies.

Question 7

What is the safety profile of MSM supplementation?

Answer 7

Generally recognized as safe and well-tolerated up to 4 g per day.
Mild adverse effects: GIT symptoms (nausea, diarrhea, bloating), headaches, difficulty concentrating, insomnia.

Question 8

Are there any interactions associated with MSM supplementation?

Answer 8

No known interactions have been reported.