micro: atypical pathogens 2

Question 1

What are the two Intracellular pathogens we care about?

Answer 1

Chlamydia, Rickettsia

Question 2

What are the three primary intracellular Chlamydia pathogens?

Answer 2

C. Trachomatis, C. Psittaci, C. Pneumoniae

Question 3

Chlamydia cannot produce _______ thus must live intracellularly.

Answer 3

ATP

Question 4

What are the two variants of Chlamydia trachomatis?

Answer 4

1. Sexually transmitted disease
2. Trachoma - ocular inflammation

Question 5

Sexually transmitted Chlamydia trachomatis can lead to what forms of conjunctivitis?

Answer 5

Adult inclusion conjunctivitis, Neonatal conjunctivitis

Question 6

Trachoma is caused by?

Answer 6

Chlamydia trachomatis

Question 7

What is the #1 cause of infectious blindness in underdeveloped countries?

Answer 7

Trachoma

Question 8

How can trachoma be transmitted?

Answer 8

Direct contact or flies

Question 9

What is the most common cause of chronic follicular conjunctivitis in patients in their 20s and 30s?

Answer 9

Chlamydia trachomatis

Question 10

Signs of Adult Inclusion Conjunctivitis from Chlamydia?

Answer 10

Follicles in fornix, Superior follicles, Infiltrates, Pannus

Question 11

Signs of Trachoma from Chlamydia?

Answer 11

Papillo-follicular reaction, Severe pannus, Linear scars, Arlt line, Herbert pits, Cicatrization

Question 12

Chlamydia psittaci causes a ____________ infection transmitted to humans via contact with __________.

Answer 12

Avian, Feces

Question 13

Ocular Symptoms of Chlamydia psittaci?

Answer 13

Follicular conjunctivitis, Scarring

Question 14

Rickettsia transmission?

Answer 14

arthropods

Question 15

Shape of Rickettsia?

Answer 15

Small rod-like shapes

Question 16

Rickettsia parasitizes ____________ cells.

Answer 16

Endothelial cells

Question 17

Rickettsia rickettsii causes?

Answer 17

Rocky Mountain Spotted Fever

Question 18

Rickettsia rickettsii vector?

Answer 18

tick

Question 19

When is Rickettsia rickettsii present during the year?

Answer 19

During the warmer months

Question 20

Ocular signs of Rickettsia rickettsii?

Answer 20

Vasculitis, Choroiditis, Vitritis, Macular edema

Question 21

Treatment for Rickettsia rickettsii?

Answer 21

Doxycycline

Question 22

Coxiella burnetii causes what?

Answer 22

Q-fever and gives pneumonia

Question 23

Coxiella burnetii shows an association to what animals?

Answer 23

Livestock

Question 24

Ocular signs/symptoms of Coxiella burnetii?

Answer 24

Uveitis and panuveitis potential for exudative RD

Question 25

Spirochetes shape?

Answer 25

corkscrew shaped

Question 26

Spirochetes pathogens?

Answer 26

Treponema Pallidum (syphilis), Borrelia burgdorfi (lyme disease), Leptospirosis interrogans

Question 27

Treponema pallidum causes ____________.

Answer 27

syphilis

Question 28

Stages of Treponema pallidum (syphilis) and signs associated with each stage:

Answer 28

Primary - chancre at site, Secondary - rash, Tertiary - iritis

Question 29

Two tests of Treponema pallidum?

Answer 29

-Non-treponemal tests: nonspecific -Treponemal tests : Reactive for life, most sensitive

Question 30

Non-treponemal tests for Treponema pallidum?

Answer 30

RPR and VDRL screen

Question 31

What does the non-treponemal test tell us?

Answer 31

Whether the disease is active or not

Question 32

Treponemal tests for Treponema pallidum?

Answer 32

FTA-ABS or TPPA

Question 33

What does the treponema test tell us?

Answer 33

Has the person ever had it?

Question 34

Ocular signs of syphilis?

Answer 34

Lid chancre, uveitis

Question 35

Congenital signs of syphilis?

Answer 35

Salt and pepper retinopathy, Keratitis, Uveitis

Question 36

Borrelia burgdorferi size compared to Treponema pallidum?

Answer 36

Twice the size

Question 37

Borrelia burgdorferi causes _________________?

Answer 37

Lyme disease

Question 38

Primary reservoir of Lyme Disease (borrelia)?

Answer 38

Mice

Question 39

What transmits Lyme disease (borrelia) between mice and deer or humans?

Answer 39

Ixodes Tick

Question 40

After months to years with Lyme Disease what symptoms can present?

Answer 40

Chronic arthritis, CNS disease, Iritis

Question 41

Leptospirosis interrogans shape?

Answer 41

Tightly coiled

Question 42

Leptospira interrogans transmission?

Answer 42

Contaminated food or water

Question 43

How does leptospirosis enter the body?

Answer 43

Through abrasions or the conjunctiva

Question 44

Main Ocular signs of leptospirosis?

Answer 44

Uveitis

Question 45

What is the most common cause of chronic follicular conjunctivitis in the 3rd and 4th decade?

Answer 45

Chlamydia

Question 46

What are the 2 strains of Trachomatis?

Answer 46

Trachoma, Sexually transmitted disease

Question 47

Chlamydia psittaci is related to _________ exposure?

Answer 47

Bird

Question 48

Rickettsia parasitize _____________ cells?

Answer 48

Endothelial

Question 49

Rickettsia rickettsii causes what?

Answer 49

Rocky Mountain Spotted Fever

Question 50

What transmits Rickettsia rickettsii?

Answer 50

Deer tick

Question 51

C. burnetti cause ???

Answer 51

Q-fever

Question 52

Treponema pallidum causes what?

Answer 52

syphilis

Question 53

Two testing types for Treponema?

Answer 53

RPR/VDRL - for active, FTA-ABS/TPPA - reactive for life

Question 54

Borrelia burgdorferi causes _________?

Answer 54

Lyme disease

Question 55

Borrelia burgdorferi is transmitted by?

Answer 55

Deer ticks

Question 56

Reservoir of Borrelia burgdorferi?

Answer 56

Mouse

Question 57

Leptospira shape?

Answer 57

Tightly coiled spiral