Musculoskeletal - Benign Bone disorders Flashcards Preview

My NBCE Part 1 - Pathology Study > Musculoskeletal - Benign Bone disorders > Flashcards

Flashcards in Musculoskeletal - Benign Bone disorders Deck (43):
1

Loss of bone quantity while bone quality is normal.

osteoporosis

2

Senile type of osteoporosis is MC in _____ and due to lack of ________

Men
Growth hormone

3

Loss of bone quality with softening of the bone.

osteomalacia

4

Looser's zones on x-rays of bones.

osteomalacia

5

Loss of bone quality in children, bowlegs and Rachitic rosary (swollen costochondral joints) decrease vitamin D

rickets

6

Brown (hemosiderin) bone cysts and hypercalcemia due to hyperparathyroidism.

osteitis fibrosa cystica

7

Reduced bone mineral density, age, postmenopausal women, nutrient deficiency, much worse in women.

osteoporosis

8

Osteoporosis MC fracture sites:

Vertebral body compression
Femoral neck

9

Osteolysis followed by deposition of disorganized bone, enlarged bone that lacks strength, "shaggy" appearance.

Paget's disease

10

Shows up on x-ray with "Ivory vertebra" and also seen axial skeleton, femur, skull, pelvis and has fractures and nerve compression.

Paget's disease

11

Disruption of vascular supply to bone (fracture), bony necrosis, hip and shoulder.

Avascular necrosis

12

Arrested development of bone, bone softening, most sever when involving multiple bones (polyostotitc), femur (Shepard's crook), craniofacial distortion, sever distortion.

Fibrous dysplasia

13

Polyostotic dysplasia, café-au-lait spots precocious puberty (endocrinopathy).

McCune-Albright syndrome

14

Malignant, adolescent, Caucasians, femur, pelvis, periosteal reaction (onion skinning)

Ewing sarcoma

15

Bone marrow infection, S. aureus, M tuberculosis, involucrum

Osteomyelitis

16

Pronounced ankylosis on the anterior segment of vertebral bodies, common on anterior cervical vertebrae, "flowing ossification" or "melted candle wax", idiopathic, diabetes.

Diffuse Idiopathic Skeletal Hyperostosis (DISH)

17

DISH aka

Forestier's disease

18

Benign, round lesion, smaller than 2 cm in diameter, subcortical, central nidis (radiolucent), pain, nocturnal pain that is relieved by aspirin.

Osteoid osteoma

19

Malignant, aggressive, adolescents, periosteal reaction (Codman's triangle, sunburst), metaphyseal region of long bones, very common around knee, amputation.

osteosarcoma

20

MC bone forming tumor in adolescents.

osteosarcoma.

21

Benign, large cartilage-capped outgrowth, metaphysics, males, age 10-30, slow growing, cortex merges, common around knee

Osteochondroma

22

Several osteochondromas called?

Multiple hereditary exostosis

23

Benign, circular lucency with a narrow ring of sclerosis, almost always in hands.

enchondroma

24

Multiple enchondromas of the hand

Ollier disease

25

Malignant, periosteal reaction (thinning or thickening), adult males, pelvis, shoulders, may develop inside medullary cavity and may expand into surrounding soft tissue (palpable mass)

Chondrosarcoma

26

Fibroblast growth factor receptor gene mutation, shortening of long bones, frontal bossing, Midvale hypoplasia, bullet vertebrae, central spinal canal stenosis.

achondroplasia
Congenital disorder

27

Brittle bone disease, abnormal type I collagen, affects all extracellular matrix, weak bones, skin, joints, irregular teeth, hearing loss.

Osteogenesis imperfecta

28

Stone bone, dysfunctional osteoblasts, marrow fills, fractures, cranial nerve palsied, Erlenmeyer flask deformities.

Osteopetrosis

29

MC degenerative joint disorder.

osteoarthritis

30

Degenerative joint disorder, altered articular cartilage, age-related, trauma, infection may accelerate, associated with subchondral cysts, Herberden nodes

osteoarthritis

31

Gout MC in

males

32

Gout is abnormal _____ metabolism.

purine

33

Gout: Uric acid crystals in synovium called?

tophi

34

Gout MC in ______ (pdagra)

hallux

35

Calcific tendonitis, hydroxyapatite deposition into the tendons, idiopathic, 40-70 yrs old, reduced range of motion, pain, swelling

HADD
Hydroxyapatite deposition disease

36

HADD MC involves what?

Rotator cuff muscles (supraspinatus)

37

Phosphate deposition into cartilage, knee, wrist, faint Calcific appearance in joint space, elderly.

Calcium pyrophosphate deposition disease CPPD

38

CPPD aka?

pseudogout

39

Borrelia burgdorferi from lxodes deer tick, early bullseye rash (erythema chromium migrans

Lyme arthritis

40

Aggressive skeletal muscle cancer, children, head, neck. What cells?

Rhabdomyosarcoma
rhabdomyoblasts

41

Malignant smooth muscle tumor, uterus (females), cigar shaped nuclei

Leimyosarcoma

42

Benign smooth muscle tumor. Uterine fibroids, small intestine

leiomyoma

43

Soft tissue calcification of hands (CREST syndrome), commonly involves hands.

scleroderma