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SECOND SEM 3rd YEAR > MYCO & VIROLOGY L8 (Semis- Hepatitis Viridae) > Flashcards

MYCO & VIROLOGY L8 (Semis- Hepatitis Viridae) Flashcards

1
Q

3 Possible Causes of Hepatitis

A
  1. Infectious Agents (virus, bacteria, parasite)
  2. Alcohol
  3. Drugs (Drug-induced hepatitis)
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2
Q

Primary Hepatitis (95%) includes:

A

Hepatitis A, B, C, D, E, G virus

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3
Q

Secondary Hepatitis include

A

Yellow fever virus, EBV, CMV, HSV, Rubella virus

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4
Q

Viral Hepatitis can cause:

A
  • Chronic Hepatitis which leads to Cirrhosis and to Hepatocellular Carcinoma (w/ cirrhosis)
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5
Q

Forms of Viral Hepatitis:

A

Acute
Fulminant Acute
Subclinical
Chronic

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6
Q

No signs and symptoms

A

Subclinical

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7
Q

Leads to coma bec. of the accumulation of ammonia. Also leads to liver failure

A

Fulminant Acute

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8
Q

IDENTIFY:
Family: Picornaviridae
Genus: Enterovirus/Hepatovirus

A

Hepatitis A

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9
Q

IDENTIFY:
Family: Hepadnaviridae
Genus: Orthohepadnavirus

A

Hepatitis B

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10
Q

IDENTIFY:
Family: Flaviviridae
Genus: Hepacivirus

A

Hepatitis C

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11
Q

IDENTIFY:
Family: Hepeviridae
Genus: Hepevirus

A

Hepatitis E

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12
Q

Old Family and Genus Name of Hepatitis E

A

Family: Caliciviridae
Genus: Calicivirus

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13
Q

IDENTIFY:
Family: Flaviviridae
Genus: Flavivirus

A

Hepatitis G

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13
Q

IDENTIFY:
Family: Deltaviridae
Genus: Deltavirus

A

Hepatitis D

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14
Q

NOTE: family name ends with
-viridae, while genera ends with
-virus

A
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15
Q

Its other names include Infectious Hepatitis, Enterovirus 72, and Short Incubation Hepatitis

A

Hepatitis A

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16
Q

IDENTIFY based on the incubation period:

a) 40 - 180 days
Average 60 - 90 days

b) 30 - 50 days

c) 15 - 150 days

d): 2 - 9 weeks

e) 15 - 45 days
Average of 28 days

f) Not established

A

a) Hepatitis B
b) Hepatitis C
c) Hepatitis D
d) Hepatitis E
e) Hepatitis A
f) Hepatitis G

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17
Q

IDENTIFY: based on morphology
1) Enveloped, Icosahedral, Linear, ssRNA, 45 nm

2) Naked (resistant to ether, acid, heat at 60C for 1 hour), icosahedral, linear, ssRNA, 28 nm

3) Naked, Icosahedral, Linear, ss RNA, 30 nm

4) enveloped, Icosahedral, Circular, dsDNA, 42 nm

5) Enveloped, Circular, ssRNA, 37 nm

6) ssRNA. (Size not stated)

A

1) Hepatitis C
2) Hepatitis A
3) Hepatitis E
4) Hepatitis B
5) Hepatitis D
6) Hepatitis G

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18
Q

Indicates immunity in Hep A

A

IgG anti- HAV

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19
Q

The first one to appear in Hep A

A

HAV Ag

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20
Q

IgM anti-HAV is detected by?

A

Solid Ab ELISA

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21
Q

IgG anti-HAv is detected by?

A

Competitive inhibition ELISA

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22
Q

Treatment for Hep A

A

Supportive Care

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23
Q

Prevention/ Vaccine for Hep A

A
  • Inactivated vaccine (Twinrix) 2 doses with 1 month interval
  • Treatment of water
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24
Q

This hepatitis is subclinical, has no Chronic Disease, and is self-limiting

A

Hepatitis A

25
Q

Other names of Hepatitis B (state at least two)

A
  1. Serum Hepatitis
  2. Dane Particle
  3. Long Incubation Hepatitis
  4. Australian Hepatitis
26
Q

Identify based on MOT:

1) Parenteral, Sexual Intercourse

2) fecal-oral route

3) Parenteral, Perinatal, Sexual Intercourse

4) Parenteral, Sexual Intercourse, Co-infection with Hepa B virus (HBsAg needed by the virus)

A

1) Hepatitis C & G
2) Hepatitis A & E
3) Hepatitis B
4) Hepatitis D

27
Q

Treatment and vaccine for Hepatitis B

A

Treatment:
- Supportive Care
- HB immunoglobulin
- Interferon
- Lamivudine
- Liver Transplant

Vaccine: Inactivated vaccine (3 doses)

28
Q

First marker to appear during HBV

A

HBsAg

28
Q

First antibody to appear in HBV

A

IgM anti - HBc

28
Q

Lifelong marker of HBV infection

A

IgG anti - HBc

29
Q

No serological significance; for liver biopsy.

A

HBcAg

29
Q

Last to appear for immunity in HBV

A

Anti-HBs

30
Q

Epidemiological Data:
Blood and blood products
transfusion, contact history, and inoculation history.

A

HB, HC, HD, HG

30
Q

HBV window period

A

Anti-HBc

30
Q

First Generation Serologic Test for Viral Hepatitis

A

Ouchterlony agar plate

31
Q

Third Generation Serologic Test for Viral Hepatitis

A
  • RIA, ELISA, Reverse Passive Hemagglutination
  • Reverse Passive Latex Agglutination
32
Q

Second Generation Serologic Test for Viral Hepatitis

A

Counter electrophoresis (countercurrent immunoelectrophoresis)

32
Q

This is observed with an increase in liver function test (LFT)

A

Chronic Persistent Hepatitis

33
Q

This is observed with a decrease in liver function test (LFT)

A

Chronic Active Hepatitis

34
Q

Prevention/ Vaccine for Hepatitis C

A

No vax available

35
Q

Treatment for Hepatitis C (SIRL)

A
  • Supportive care
  • Interferon
  • Ribuvirin
  • Liver Transplant
35
Q

Indicates TB (mg/dL)

A

0.2-1.0 mg/dL

36
Q

Major cause of liver cirrhosis plus alcoholic hepatitis

A

Hepatitis C

37
Q

Indicates Jaunice (mg/dL)

A

> 2mg/dL

38
Q

Clinical Findings of Viral Hepatitis

A
  • Fever
  • Anorexia
  • Nausea
  • Vomiting
  • Jaundice
  • Dark urine
  • Pale feces
  • Elevated transaminase
39
Q

Used for diagnosis of Hepatitis C (2pts)

A

Anti – HCV and HCV - RNA

40
Q

Its symptoms include jaundice, indigestion and difficulty sleeping, swelling of the feet and legs, and liver complications (e.g. liver failure or liver cancer)

A

Hepatitis C

40
Q

Used for diagnosis of Hepatitis A (3pts)

A
  1. HAV Ag
  2. IgM anti - HAV
  3. IgG anti - HAV
41
Q

Defective Virus - no gene or incomplete virus

A

Hepatitis D

42
Q

Prevention/Vaccine for Hepatitis E

A

No vax available

42
Q

Treatment for Hepatitis E

A

Supportive care
Self - limiting

43
Q

Used for diagnosis of Hepatitis E (3pts)

A
  1. HEV Ag
  2. IgM Anti-HEV
  3. HEV RNA
44
Q

Detected by ELISA, Western blot
and Fluorescence Antibody Blocking Assay

A

IgM Anti-HEV

44
Q

Its symptoms include nausea, vomiting, pain in the right hypochondrium, intoxication, severe weakness, malaise, bleached feces

A

Hepatitis E

45
Q

Detected using RT-PCR

A

HEV RNA

45
Q

Treatment for Hepatitis G

A

Supportive care

46
Q

Epidemiological Data:
Food, water, seasonal, age

A

HA, HE

47
Q

Treatment for Chronic Hepatitis

A
  • Symptoms Therapy
  • Diet
  • Rest
  • Supporting Therapy
  • Immunomodulator
48
Q

Treatment for Fulminant Hepatitis

A

General and Supporting Therapy
Rest: strict bed rest, diet

49
Q

Protection of Susceptible Population

A
  • Active Immunity
  • Passive Immunity
50
Q

Prevention of Hepatitis

A
  • Control of source of infection
  • cost off route of infection

cut off guro??

SECOND SEM 3rd YEAR (38 decks)

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