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RUSVM Bacteriology Gram Positives > Mycobacterium > Flashcards

Flashcards in Mycobacterium Deck (52)
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31

Tuberculosis vaccine>

Available - Temporary immunity & hypersensitivity in humans - Interferes with interpretation of testing so ONLY for eradicated places

32

Mycobacterium avium subspecies

4 subspecies (avium, paratuberculosis, silvaticum, hominissuis)

33

When I say Johne's disease, you say...

Mycobacterium avium paratuberculosis!

34

When I say transverse corrugation of intestinal mucosa of ruminants, you say...

Johne's Disease! Mycobacterium avium paratuberculosis!

35

M. avium paratuberculosis

Johne's Disease! Chronic, irreversible wasting disease. **REPORTABLE**

36

M. avium paratuberculosis - species affected

Symptomatic/asymptomatic in wild & domestic ruminants, swine & rabbits

37

M. avium paratuberculosis transmission

Ingestion - contact with fecally-contaminated materials (in utero or colostrum ingestion also possible

38

Johne's Disease pathogenesis

Cell mediated immune phenomena (12 mo incubation pd) --> survive & replicate inside M cells** --> macrophages release cytokines--> TH1 recruited (tuberculoid stage) --> IFN-g compromised, fails to eliminate bacteria --> Progressive granulomatous reaction (TH2 recruitment) --> sloughing of mucosal epithelium=lepromatous stage

39

Johne's Disease pathogenesis Lepromatous stage

TH2 recruitement - Sloughing of mucosal epithelium

40

Johne's Disease pathogenesis Tuberculoid stage

TH1 recruitment

41

Johne's Disease in ruminants

Chronic weight loss, diarrhea, permanent transverse corrugation of intestinal mucosa - Enlarged draining lymph nodes w/ macrophages w/bacteria

42

Johne's Disease - breeds especially susceptible

Guernsey, Shorthorn, Jersey

43

Johne's Disease When disease most occurs

In young - Domestication/captivity - Stress, crowding, shipment etc

44

Johne's Disease Dx

Intradermal test - can be messed up with vaccination

45

Feline leprosy - causative agent & description

M. lepraemurium - chronic noduloulcerative nonTB mycobacterial infection of skin - Transmission by rodent bite - Poor prognosis

46

M. lepraemurium description

Acid fast agent, very fastidious (picky about growth medium)

47

Canine Leproid Granuloma Syndrome

Uncultured, saprophytic mycobacterium - Numerous acid-fast organisms - Condition of subcutis & skin of pinnae, face, body extremities

48

Ulcerative dermatitis of cats & dogs - Causative agents

M. fortuitum, M. chelonae, & others

49

Ulcerative dermatitis of cats & dogs - Description

Chronic, non-healing skin lesions, months to years - Pyogranulomatous inflammation - poor-staining organisms

50

Bovine Farcy

Bovine Mycobacterial Ulcerative Lymphangitis - Nodular-ulcerative skin lesions of lower extremitis & ventral trunk - May cause false positive tuberculin reactivity

51

Bovine Farcy causative agents

M. farcinogenes, M. senegalenses (and Nocardia farcinca)

52

Mycobacterium in aquatics

Zoonotic significance - "swimming pool granuloma" or "fish handler's disease"