Flashcards in Neurotransmission + CNS drug action Deck (13)
1
describe the difference between electrical and chemical synapses
electrical = dendrite - dendrite
chemical = axon + dendrite
2
what are the amine neurotransmitters
5HT, NA, dopamine, Histamine
3
which neurotransmitters main pathways are
raphe nucleus
locus coeruleus
basalis of Maynert
5HT
NA
Ach
4
Name the 2 dopamine pathways and the diseases that correspond
1) nigrostralial path - parkinsons
2) mesolimbic and mesocortical - schizophrenia
3) tuberoinfundibular path
5
Name the two types of neurotransmitter receptors
ligand gated ion channels
g protein coupled receptors
6
Give 2 examples of ion channel neurotransmittor receptors
GABA - ligand gated. pentameric - allosteric change opens CL- channels
NMDA - glutamate big ion channel.
7
name the co-transmitter for NMDA receptor
glycine
8
describe the mechanism of a G protein coupled receptor using the example of adrenoceptor a1,a2,b2
B2 causes GTP bind to GS receptor releasing GDP . binding causing increased camp production.
A2 causes GTP to bind to a GI receptor releasing GDP. this causes decreased camp production.
A1 - increases intracellular ca2+ GQ receptor
9
2 benefits to g protein coupled receptors
signal amplification
one NT can have multiple effects depending on the receptor.
10
describe somatodendritic autoreceptors and terminal autorecceptors
SD - turn down rate of APs
T - turns down release of NT
11
name a drug that acts on each of the following:
1- synthesis
2 - metabolising
3- release
4- termination
1 - L DOPA
2 - MAOIs
3 - amphetamines
4 - TCA
12
Action of cocaine
NA and DA reuptake inhibitor
13