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Flashcards in Neurotransmission + CNS drug action Deck (13)
1

describe the difference between electrical and chemical synapses

electrical = dendrite - dendrite
chemical = axon + dendrite

2

what are the amine neurotransmitters

5HT, NA, dopamine, Histamine

3

which neurotransmitters main pathways are
raphe nucleus
locus coeruleus
basalis of Maynert

5HT
NA
Ach

4

Name the 2 dopamine pathways and the diseases that correspond

1) nigrostralial path - parkinsons
2) mesolimbic and mesocortical - schizophrenia
3) tuberoinfundibular path

5

Name the two types of neurotransmitter receptors

ligand gated ion channels
g protein coupled receptors

6

Give 2 examples of ion channel neurotransmittor receptors

GABA - ligand gated. pentameric - allosteric change opens CL- channels
NMDA - glutamate big ion channel.

7

name the co-transmitter for NMDA receptor

glycine

8

describe the mechanism of a G protein coupled receptor using the example of adrenoceptor a1,a2,b2

B2 causes GTP bind to GS receptor releasing GDP . binding causing increased camp production.
A2 causes GTP to bind to a GI receptor releasing GDP. this causes decreased camp production.
A1 - increases intracellular ca2+ GQ receptor

9

2 benefits to g protein coupled receptors

signal amplification
one NT can have multiple effects depending on the receptor.

10

describe somatodendritic autoreceptors and terminal autorecceptors

SD - turn down rate of APs
T - turns down release of NT

11

name a drug that acts on each of the following:
1- synthesis
2 - metabolising
3- release
4- termination

1 - L DOPA
2 - MAOIs
3 - amphetamines
4 - TCA

12

Action of cocaine

NA and DA reuptake inhibitor

13

What do neurotransmitter reuptake transporters swap neurotransmitters for

Na+ and Cl-