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Flashcards in Osteomyelitis Deck (13):
1

What must occur to create osteomyelitis

Negative event like trauma or foreign body or inoculation with biofilm producing or implant adhering infectious agent

2

How is osteomyelitis classified in vet med

Route of infection (hematogenous or post traumatic)
Time of disease onset (acute, subacute, chronic)

3

osteomyelitis time line
1) Acute
2) Subacute
3) Chronic

1) develops within two week
2) develops within several months
3) develops after a few months

4

What is a major predisposing factor in the development of osteomyelitis and how does it occur

Ischemia. Loss of vascular channels (Haversian and Volkmanns canals and canniliculi) secondary to necrosis and resorption during acute inflammatory phase

5

Radiographic evidence suggestive of the aggressiveness of the infection

Less aggressive appears as thickening of the bone
More aggressive shows a lamellated (onion skin) layering
Aggressive calcified streaks perpendicular to the bone

6

What influences the damage from and response to treatment of osteomyelitis

Viability of the bone
Virulence of the infectious orgs
Condition of the soft tissue envelope

7

Where does hematogenous osteomyelitis usually occur
3 reasons why

Metaphysis
sinusoidal capillaries (no basement membrane (BM), discontinuous endothelium/capillary)
Sluggish circulation
No leukocytes in developing spongiosa

8

Most common cause of osteomyelitis and organism

Trauma and Staphylococcal 60% (particularly Staph intermedius

9

4 stages of a biofilm

Reversible attachement, irreversible attachment, growth and differentiation, dissemination or detachment

10

Why are biofilms resistant to antimicrobials

Acts as a filter and barrier
Quiescent growth (If MOA impedes growth and repro its ineffective)
Harsh environment (acidic, increased PCO2 and low PO2)

11

Diagnosis

Biopsy and culture

12

Tx

Drain, debridement (explant), lavage
IV abs (5-7 days) then oral for at least 4 weeks

13

Azab, MA et al. VCOT 2016
Eval of silver impregnated coating for implants to inhibit colonization of meth resist staph pseudointermedius

Reduced MSRP colonization by 99.98% after 24 hours of inoculation