•Overview of the liver Flashcards Preview

GI > •Overview of the liver > Flashcards

Flashcards in •Overview of the liver Deck (28):
0

_____ of blood comes into the liver from the hepatic artery

450 ml/min

1

Liver functions

-regulation of protein, carbohydrate and lipid metabolism -regulation of cholesterol production and excretion -β-oxidation of fatty acids -bile acid production -degradation of hormones -detoxification and excretion of drugs and toxins -vitamin storage

2

_____ of blood comes into the liver from the portal vein

1 liter/min

3

the pressure in the hepatic vein is under _____

1 mmHg

4

interstitial space between parenchymal hepatocytes where lymph is secreted:

space of Disse

5

canals that bile flows through:

bile canaliculi

6

the hallmark obstructive liver disease is ____, which is characterized by ____

cirrhosis, scarring

7

ascites formation

increased hepatic vein pressure ---> pooling of blood in liver capillaries---> increased capillary hydrostatic pressure ---> increased transudation of fluid from plasma and space of Disse into the peritoneal cavity of the abdomen forming ascites

8

because lymphatics are also involved, in ascites, you get ____ in the fluid

proteins

9

if you have minor ascites, the _____ can absorb fluid to take care of it

greater omentum

10

there is normally ____ of blood in the liver. In hepatomegaly, the liver can increase to ____

400 ml, 1 L

11

jaundice

yellowing of skin and eyes from excess bilirubin in the blood

12

bilirubin is a product of ___

RBC metabolism

13

obstructive jaundice

obstruct the ability of bile to be made or secreted so it ends up in the blood instead- cirrhosis, gallstones, biliary atresia, cancer

14

hepatic jaundice

can result from acute or chronic hepatitis, reduces the ability of the hepatic cells to metabolize bilirubin. ex. alcoholic hepatitis

15

hemolytic jaundice

results from anything that increases hemolysis of RBC's, so that bilirubin production increases faster than bile can excrete it

16

neonatal jaundice

not usually pathologic, the GI tract is not mature enough/prepared to process the bilirubin and excrete it

17

how does the liver function as a blood glucose monitor?

glycogen storage, glycolysis, and gluconeogenesis

18

what hormone stimulates insulin secretion

GIP

19

the liver has ____ family glucose transporters which are insulin-_____, allowing for ____

GLUT2, insulin-independent, high capacity transport (can't wait for insulin)

20

if you didn't have the liver, your blood glucose levels would be about ____ higher

3 times

21

most lipoproteins are formed in the ___

liver

22

what do HDL's do?

ship lipids back to the liver for processing

23

the liver converts unused carbs to ____

TG

24

how does deamination of amino acids occur?

aminotransferases remove the amino group to an acceptor. It is transferred or released as ammonia.

25

excess NH3 is removed by production of ____. How does this happen?

urea, NH3 combines with CO2

26

___% of plasma proteins (i.e. ____) are made by the liver

90, albumin, globulins, fibrinogen

27

what symptoms may occur if the liver can't function?

ascites, jaundice, portal hypertension, bleeding/bruising, cognitive problems, weakness, nausea, cholestasis (reduced bile flow), acidosis