PATHO LEC: Me MODULE 5 Flashcards
This process replaces injured tissue with cells of the same type.
Regeneration
The process where damaged tissue is replaced by fibrous connective tissue.
Connective tissue replacement
These cells continuously proliferate throughout life and replace destroyed cells.
Labile cells
Cells that replicate at low levels but can divide rapidly when stimulated.
Stable cells
Cells that do not replicate significantly after birth, including neurons and cardiac muscle.
Permanent cells
The type of repair that predominates when permanent cells are damaged.
Connective tissue replacement
The specialized tissue composed of fibroblasts and new blood vessels during healing.
Granulation tissue
The process by which new blood vessels form from pre-existing vessels.
Angiogenesis or neovascularization
This growth factor is found in platelets and stimulates fibroblast and smooth muscle proliferation.
Platelet-derived growth factor (PDGF)
This growth factor stimulates fibroblast proliferation and angiogenesis.
Fibroblast growth factor (FGF)
The first step in angiogenesis, involving degradation of the basement membrane.
Enzymatic degradation of parent vessel
The excessive formation of granulation tissue that prevents re-epithelialization.
Proud flesh (exuberant granulation)
An overproduction of collagen leading to large, bulging scars.
Keloid formation
The type of healing where wounds are closed with minimal tissue loss and contamination.
First intention healing (primary union)
A type of healing that occurs with large tissue loss and results in wound contraction.
Second intention healing (secondary union)
The phenomenon where specialized fibroblasts reduce the size of a wound.
Wound contraction by myofibroblasts
The process of collagen accumulation and regression of excess blood vessels in healing.
Blanching of the wound
The fundamental unit of collagen that provides tensile strength to wounds.
Tropocollagen
The vitamin necessary for collagen hydroxylation and wound healing.
Vitamin C (Ascorbic acid)
A genetic disorder resulting in hyperextensible skin and hypermobile joints due to collagen defects.
Ehlers-Danlos Syndrome (EDS)
A genetic disorder affecting collagen cross-linking, leading to skeletal, skin, and vascular defects.
Marfan’s Syndrome
The percentage of unwounded skin strength retained in a sutured wound immediately after surgery.
0.7
The percentage of original wound strength after suture removal at one week.
0.1
The final percentage of wound tensile strength reached after 3-4 months.
70-80%
