Pathology - Leucocytes And Their Function Flashcards Preview

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Flashcards in Pathology - Leucocytes And Their Function Deck (11):
1

What is the nuclear morphology and function of a neutrophil?

2-5 segments in nucleus.
Fine granules (primary and secondary)
- phagocytic function
-9-15um diameter

2

What is the nuclear structure and function of an eosinophil?

2 lobed nucleus, large round granules.
Weakly phagocytic, involved in allergy and inflammation, kills parasites
-12-17um diameter

3

Name the different types of granular leukocytes

Neutrophil, basophil, eosinophil

4

What is the nuclear structure and function of a basophil?

2 segments in nucleus, purple black granules, large and round.
Involved in allergy, inflammation, parasite response
-12um diameter

5

What is the nuclear structure and function of a monocytes?

Horseshoe shaped nucleus, grey cytoplasm, few granules, vacuoles.
Becomes a macrophage, causes phagocytosis, present in chronic infection, involved in processing and presentation of antigen on MHC 2.
Secrete proinflammatory, immunoregulatory, anti inflammatory, and cytokine molecules
15-30um diameter

6

What is the main function of a B cell lymphocyte?

Produce antibodies (immunoglobulin/Ig)

7

What is the main role of a T cell lymphocyte?

Direct binding of foreign antigens.
Cell mediated immunity
About 70-85% of lymphocytes are T-cells (T:B ratio = 6:1)

8

What is the nuclear morphology of a plasma cell, what is its function, and what cells do these cells originate from?

Eccentric nucleus, clumped chromatin, produce monoclonal antibodies & immunoglobulins.
Plasma cells are terminally differentiated B cells

9

What is the structure (nuclear) of a megakaryocyte and what is the function of this cell?

Large cell, hyperlobated nucleus, centrally located.
Generates platelets

10

What is the structure and function of a platelet?

Anuclear cell fragments that contai cytoplasmic granules. They adhere to and plugs breaches in blood vessel walls AKA they're involved in clotting cascades

11

Describe the development of a neutrophil, from a myeloid stem cell

Myeloid SC
Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Band form
Neutrophil

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