Pathology of Pulmonary Neoplasia Flashcards
1
Q
What is the most important cause of lung cancer?
A
Exposure to tobacco related carcinogens (smoking)
2
Q
How many recognised carcinogens are there in usual cigarettes?
A
Around 60
3
Q
What are the 2 main pathways of lung carcinogenesis?
A
Lung Periphery
Central Lung Airways
4
Q
What type of stem cells transform into dysplastic epithelium?
A
The bronchial epithelium
5
Q
Which common oncogene mutation is linked to smoking?
A
KRAS mutation
6
Q
Why are lung canacers generally harder to operate on than other cancers?
A
Because they are picked up later, due to growing ‘clinically silent’ for years
