Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Step 1 Clues > pharm > Flashcards

pharm Flashcards

(307 cards)

Start Studying
1
Q

What drugs act as haptens on platelets?
Leads to thrombocytopenia

A

Aspirin
Heparin
Quinidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What drugs act as haptens on RBCs
Causing anemia

A

“PAD PACS”
- Penicillamine
- a-MeDopa
- Dapsone
-PTU
- Antimalarials
- Cephalosporins
- Sulfa drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What drugs wipe out the bone marrow?

A

“ABCV”
AZT
Benzene
Chloramphenicol
Vinblastine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What drugs wipe out granulocytes?

A

Carbamazepine
Clozapine
Ticlopidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drugs cause pulmonary fibrosis

A

ABBTM

Amiodarone
Busulfan
Bleomycin
Tocainide
Methotrexae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What drugs dilate veins and arteries?

A

ACE-I and Nitrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the anti-inflammatory actions of steroids?
SIK

A
  • Stabilizes: mast cells/endothelium
  • Inhibits: MP migration/ PLA
    *Kills: T cells/eosinophils
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the physiological effect of steroid ?

A

*Proteolysis(starting at lower extremities )

*gluconeogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is opioid mu receptors effects on cns?

A

Mental side effect (CNS depression)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

opioid withdrawal

A

excitatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Kappa receptors function in

A

pain relief

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drugs have sulfur in them?

A

ACEI
Celocoxib
Loop diuretics
Thiazides
Sulfonylureas
Sulfonamides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the short-acting DM Type 1 drugs?

A

Lispro
Regular
Aspart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the intermediate-acting DM Type 1 drugs?

A

NPH
Lente

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the long-acting DM Type 1 drugs

A

Glargine
Ultralente

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What drugs cause SLE?

A

“HIPPPE”
Hydralizine
INH
Procainamide Phenytoin Penicillamine Ethosuximide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What antibody is associated with drug-induced lupus?

A

Anti-histone Ab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What drugs cause labor induction?

A

*PGE2 – ripens cervix
*Oxytocin – increase contractions *Pitocin – increase contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What drugs cause labor halt = Tocolytics? relax

A

*Hydration (stop ADH=oxytocin)
*MgSO4 – decrease contractions
*Terbutaline – decrease contractions
*Ritodrine – increasing edema; decrease
contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What drugs can be Nephrotoxic?

A

Water soluble drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What drugs can be Hepatotoxic?

A

Fat soluble drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How do you treat Acetaminophen overdose?

A

Fluid
Activated charcoal
N-acetylcysteine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How do you treat Benzodiazepine overdose

A

Flumazenil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

How do you treat beta blocker OD

A

Glucagon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
How do you treat CCB overdose?
Calcium Chloride + Glucago
26
How do you treat CO poisoning?
100% O2
27
How do you treat Cu, Gold, Cd, Mercury, Arsenic poisoning?
Penicillamine
28
How do you treat Cyanide poisoning?
Amyl Nitrite B12 Methylene blue Transfusion
29
How do you treat Ethylene Glycol, MeOH overdose
EtOH, Fomepizole
30
How do you treat Fe overdose?
Deferoxamine
31
How do you treat Fibrinolytic overdose?
Aminocaproic acid
32
How do you treat Heparin overdose?
Protamine sulfate
33
How do you treat Lithium overdose?
Sodium polystyrene sulfonate
34
How do you treat Nitrite overdose?
Methylene blue
35
How do you treat Organophosphate poisoning?
Atropine + Pralidoxime
36
How do you treat Opioid overdose?
Naloxone
37
How do you treat Pb poisoning?
Succimer
38
How do you treat Salicylate overdose?
Fluid Charcoal bicarbonate
39
How do you treat TCA overdose?
Bicarbonate (prevent arrhythmias)
40
How do you treat Theophylline overdose?
Esmolol
41
How do you treat Warfarin overdose?
vit k Cryoprecipitate
42
What drugs causes myositis & Hepatitis?
"RIPS" Rifampin INH Prednisone Statins
43
What drugs cause disulfiram reactions?
Metronidazole Cephalosporins Procarbazine
44
What drugs cause dysgeusia?
Metronidazole Clarithromycin Lithium
45
What antibiotics are in a triple antibiotic?
"Brand New Patient" Bacitracin Neomycin Polymyxin D
46
What is the 1-dose treatment for Chlamydia?
Doxy Pregnant: Azithromycin
47
What are the 1-dose treatments for Gonorrhea?
"Try to fix the fox with floxs" Ceftriaxone Cefixeme Cefoxitin
48
What bugs are treated with vancomycin?
MRSA Staph. epidermidis Enterococcu
49
resistance to Vancomycin, use
Linezolide
50
What is the treatment for malaria?
*Quinine – tinnitus *Mefloquine – good liver penetration *Primaquine – prevents relapse, high bug resistance Chloraquine – kills RBCs
51
What should you always remember when taking a test?
You have been empowered… You now have the eyes of physio!
52
MI: fibrinolytic factors Plasmin
from Plasminogen
53
Alteplase: tPA is indicated for treatment of
STEMI
54
MOA of tPA
Binds of fibrin convert plasminogen to plasmin=fibrinolysis
55
How do you monitor tPA
PT & PTT
56
firstline for Atypical: non productive cough
Macrolides: Azythromycin
57
MOA involves inhibiting NE and 5-HT reuptake indicated for antidepressant
TCA
58
amitriptyline, imipramine ,nortriptyline, desipramine side effect
dry eye: antimuscarinic tachycardia and urinary retention orthostatic hypotension: a-blocker QT, Torsades, AV block
59
Mannitol salt agar turns yellow with
S. aureus
60
transmitted by undercook pork in HIV pt
ring-enhancing lesions of the brain with toxoplasmosis gondii
61
phosphodiesterase inhibitors
caffeine Theophylline Sildenafil vardenafil Tadalafil
62
Nitrates, Endotoxin, ANP
elevate c-GMP : dilate veins before artery
63
membrane physio Topical anesthetic with two I Metabolize? 3 mc side effect? distribution? Charged? Size? maybe contraindicated in which patient?
amide fat soluble
64
membrane physio Topical anesthetic with one I. Metabolize? 3 mc side effect? distribution? Charged? Size? maybe contraindicated in which patient?
ester water soluble
65
Inhalational Anesthetic Fat soluble characteristics : Oil/gas partition coefficient onset? recovery? MAC?
quick slow Low
66
Inhalation anesthetics Water Soluble: Blood/gas Partition coefficient onset recovery? MAC?
slow quick High
67
Antiseizure med: membrane physio What two ions may be active during Siezure
Na Ca (only thalamus)
68
Generalized seizure defined as
loss consciousness
69
G. Seizure Med/MOA
Phenytoin Blocks: Na
70
G. Seizure in Children MED/MOA
Phenobarbital Incr. GABA
71
Thalamic Absence Seizures
Ethosuzimide Ca blocker Bone marrow/Lupus
72
Mixed or Myotonic Seizure
Valproic Acid: Na/Ca/folate birth defect bone marrow
73
Temporal lobe seizures
Carbamazepine: Na/Ca agranulocytosis
74
Febrile Seizures
Acetaminophen
75
Sumatriptan moa Indication
5-HT 1B/1D agonist Migraine txt
76
Contraindications of sumatriptan
Poorly controlled hypertensive pt and MI
77
Antiemetic:dopamine receptor antagonist that causes Parkinson’s
Metoclopramide
78
What is Reye’s syndrome
Mito damaged by aspirin during viral treatment in kids
79
Moa of thiazolidinediones n why contraindicated in heart failure pt
Decre insulin resistance in periphery and liver
80
Triple therapy for H. Pylori
Lansoprazole, Amoxicillin and Clarithromycin
81
Blocks viral glycoprotein gp41 | prevents fusion
Enfuvirtide
82
Amniotic fluid analysis shows an increase level of acetycholinesterase
fusion of the edges of the neural plate | AFP and AChE +neurotube defect
83
coarctation of aorta, bicuspid aortic valve, aortic dissection, horseshoe kidney, steak ovaries, wide chest
Turner syndrome | 45,XO
84
PCOS findings
hirsutism=hi androgens 2ndary amenorrhea Diabetes= insulin resistance Obesity
85
Pelvic inflammatory dz
STI fibrotic fallopian tubes
86
amniotic finding of down S.
AFP and normal AChE
87
Mutation in Stat3 (jak-stat) | coarse face, recurrent nontender cold absces, eczema, have primary teeth
Hyper IgE | recurrent infection, high eosinophills, low Th17 cells
88
# child Hyper IgE | low Th17 presentation
coarse face, recurrent nontender cold absces, eczema, have primary teeth
89
# infant cause of hyper IgM | no cold skin abscesses
CD40 ligan defect | opportunistic infection & Sinopulmonary infection
90
nicotine withdrawer
dysphoria irritability anxiety hi appetite
91
# cocaine, amphetamines(ADHD) Simulants withdrawal
vivid dreams, depress, hypersomnia, hyperphagia hi appetite
92
opioids withdrawer
NVD, abdominal cramping, muscle aches | lacremation, piloerction
93
# withdrawal seizures, tachycardia, tremors
benzo alcohol
94
prefers to be alone, detached and unemotional
schizoid
95
unusual magical thinking, perceptions and behavior
schizotypal
96
avoidance due to fears of criticism and rejection
Avoidant
97
MOA of lipid lowering drug effective in prevent cardiovascular events
Enzyme inhibitor | statins
98
effective triglycerides lowering
fibrates exercise & weight loss
99
effective HDL increase cholesterol lowering
niacin
100
in cholesterol therapy cationic exchange resins is moa of
bile acid sequester cholestyramine | increases cholesterol production in liver
101
in cholesterol therapy absorption inhibitor is MOA of | in GI
Ezetimibe | myositis hepetitis
102
Anti-glomerular basement membrane react with | crescent formation
collagen type IV | linear deposition of IgG, C3 along GBM
103
cytosolic pathway
glycolysis fatty acid synthesis pentose phosphat pathway
104
inhalaton of animal waste | clearning barn no hay involve
acute Q fever | coxiella burnetii
105
heavily methylated DNA at the periphery of the nucleus
low trnscription activity | heterochomatin
106
cortical atroph involving loss of cholinergic neurons
Alzheimer AD
107
what cortical degenerative dz involve low synaptic ACH degradation
alzheimer dz
108
# pathogenesis alzheimer dz
B-amyloid<-> nueuronal stress--> excitotoxic--> neuronal degeneration-->diffuse cortical atrophy loss of ACH neuron--> impaired memory & cognition
109
increase theophyline in pt with UTI
Ciprofloxacin | p450 inhibitor
110
# histology actinic keratosis | premalignant
scattered mitotic figures epidermal thickness hyperchomatic | atypical epidermal karatinocytes
111
+sense SS RNA virus introduce to host cell will begin | EG: Rhinovirus
viral protein sythesis and viral genome immediate symptom presentation
112
# infant of few month old healthy baby with frequent postpredial emesis
physiologic low tone of the LES
113
Entacapone MOA
dec peripheral levodopa degredation
114
Tolcapone MOA
dec central levodopa degredation | increase dopamine
115
carbidopa MOA
inhibit DOPA decarboxylase | increase peripheral Levodopa---> cross BBB
116
LPS is also | endotoxin induces macrophages
lipid A | septic shock
117
radial head subluxation may trap
annular ligament
118
during cervical lympnod dissection | damage nerve and muscle
spinal assesory Trapezius | SCM
119
patient taking Naltrexone | MOA
mu-opioid blocker | inhibit rewarding and reinforcing effect of alcohol, dec craving
120
flushing, wheezing, diarrhea, clonus and hyperreflexia
serotonin syndrome | cyproheptadine and octreotide
121
controls reticular activating system
serotonine | monoamine: ADD and ADHD causes of GI vomiting
122
M1 action
secretions, CNS
123
M2 action
bradycardia decrease contractility
124
M3 action
smooth muscle contraction urination, bronchial constriction GI motility | accommodation ciliary muscle
125
antihistamin anti-muscarinic anti-nicotinic receptors symptoms
Dry decrease accommodation=cycloplegia
126
use in treatment of V. Fib
epinephrine
127
high affinity fo beta 2 than beta 1receptor 2hr half-life
Epinephrine | DOC for anaphylaxis
128
causes blood pressure reversal and rhinitis medicamentosa
epi
129
DOC for septic shock
NorEpi | higher affinity for alpha and controls autonomics
130
most common decongestant
ephedrine
131
most abuse on the street: sudafed or allegra-D
psuedo-ephedrine
132
DOC for neurogenic shock: found in neo-synephrine
phenylephrine
133
block alpha, short acting, DX pheochrom'
phentolamine
134
DOC for treatment of pheochromocytoma
Phenoxybenzamine
135
Used for ED before viagra
Yohimbine
136
potent and rapid dialator with 1st dose synncope | alpha blockade
prazosin | pt must be in bed to avoid fall
137
first line for BPH | alpha antagonist
Terazosin and Doxazosin
138
fewest side effects of all the alpha 1 blockers
Tamsulosin
139
blocks catecholamines reuptake
cocaine | hi dopamine and norepinephrine
140
# receptor found in presynaptic sympa. fibers prevent NorEpi release inhibits insulin release in Islet cells of pancrease
Alpha-2
141
use for behavior problem and hypertension
Clonidine | alpha -2 agonist(G. Inhibitory)
142
DOC for HTN in 3rd trimester, causes autoimmune hemolytic anemia
Alpha methyldopa | alpha 2 agonist
143
# alpha 2 agonist used as an antidepressant, causes weight gain
mertazapine
144
Beta 1 blocker in the CNS causes
depression
145
Beta 1 in the JG apparatus cause
renin release | blocking lowers BP
146
beta 1 in the alpha cells causes
glucagon release | blocking lowers ATP in starvation
147
# B Beta 1 in SA node
speed up Heart rate and contractility | blocking slows down the heart
148
nonspecific beta-agonists
epinephrine and Norepi
149
# Receptor Bronchodilate stimulate CNS activity cardiac contractility (not rate) Covert T-4-->T3 controls insulin release uterus relaxation
Beta 2
150
# Beta 2 agonist Albuterol Terbutaline Indication
first line Asthma and Obstructive lung Disease
151
# Beta 2 agonist used in preterm labor
terbutaline and Ritodrine
152
# Beta 2 agonist long acting may conbine with steroid in asthma treatment
salmeterol and Formoterol
153
# Beta 2 agonist longest acting and given only once a day
Vilanterol
154
selective Beta 1 blocker 2A2B ME
atenolol acebutolol betaxolol bisoprolol esmolol metoprolol and nebivolol
155
selective Beta 1 blocker indication
severe heart failure obstructive lung dz advanced heart block diabetics peripheral vascular dz
156
all peripheral arterioles have which beta receptor
Beta 2
157
longest acting beta blocker
propranolol Velanterol(1/day)
158
shortest acting beta blocker use by anesthesiologists, dissecting Aortic anurysm or in pt with rapidly rising BP
Esmolol
159
used for open angle glaucoma. B-blocker
Timolol Betaxolol
160
only beta-blocker that can block potassium channel | prolonged QT
Sotalol
161
beta blocker with smooth muscle relaxant effects
Nabivolol
162
alpha 1 and beta 1/2 blocker: | use in place of Sodium nitroprusside
labetalol and carvedilol | use in pregnant women with HTN crisis and pheochromo
163
partial beta agonist effect with intrinsic sympathomimetic action
Acebutolol and Pindolol
164
breaks down catecholamines presynaptically
MAO
165
break down catecholamines post-synoptically
COMT
166
depleting dopamine and norepi causes
depression autonomic dysfunction parkinson's | guanethidine presynaptic push dopamine and norepi out their vesicle
167
use for copper and lead poisoning and everything 2+ Charge
penicillamine | cause neuropathies due to its effect on 2+ charge ions
168
treat lead and arsenic poisoning
Dimercaprol (BAL)
169
lead chelator and also use to store blood
EDTA
170
Blocks initiation factor and presynaptic influx of calcium
amino-glycoside | neuropathies
171
ca channel blocker
verapamil nimodipine nicardipine felodipine amlodipine
172
2 most potent Ca+ channel blocker
Verapamil follow by Diltiazem
173
decrease vasospasm after subarachnoid hemorrhage and decrease motality
Nimodipine
174
# 3 Top DX for chest pain
MI Dissection Angina | women present with GI complains: NVD (dyspepsia)
175
treatment for stable angina
O2 Aspirin (target platelet) Morphine(target pain cause by sympathetic response) Beta blocker if BP is high
176
heparin use in angina to | cofactor for anti-thrombin 3
block thrombin and 9, 10, 11, 12 stops clot progression
177
What ADP blocker r use for angina
Clopidogrel and ticagrelor
178
angina treatment that blocks aldosterone release
ACE inhibitor
179
HMG-COa reductase and inflammatory control
atorvastatin
180
why stop metformin in angina pt
it interact with radiocontrast in angiography | damage kidneys
181
why stop calcium channel blocker
you don't want to decrease contractility during MI
182
Nitrates use in angina to
venodilate then vasodilate
183
breaks up clot by activating palsminogen to plasmin
tPA
184
# 1st finding for cath lab
70% + stenosis in LAD left main
185
# 2nd finding for cath lab
3 or more vessel dz with 70% occlusion
186
# 3rd finding for cath lab
2 vessel dz with 70% stenosis in a diabetic | atherosclerosis is agressive in diabetic
187
3 option to keep pt on the left side of the Frank starling curve
1. O2: save the brain 2. diuretic: lowers volume (also decrease lung edema) 3. improve contractility 4. digoxin, dobutamine or dopamine
188
heart failure post mi is define as
40% myocardium loss 45% /less ejection F | left coronary artery dz 90% of the time
189
# QRS systolic dysfunction
tall and wide | S3: dialated cardiomyopathy
190
# QRS Diastolic dysfunction
S4, Tall narrow, hypertrophy, decrease filling, hi systemic resistant,
191
# Heart fialure drug and receptor dialate bld vessels in the kidney and GI, increase cardiac contractility
D1: dopamine and fenoldopam | low dose only
192
Hi dose Dopamine stimulates
alpha 1, increase TPR
193
pure Beta 1 agonist, raise hrt rate and contractility
Dobutamine
194
block K in Na/K pump causing hypoK, cellular edema and halo | papilledema, atrial arrhythmia( Na and Ca trap in cell)
digitalis
195
treat digitalis toxicity with
digibind/dagifab | antibodies...excreted through the kidneys
196
inhibits neprilysin to increase ANP..to increase kidney bld flow
Sacubitril | combo ARB+sacubitril: first line for left sided heart fialure
197
decrease TPR with
ACE-I/ARBs | decrease mortality
198
Beta blocker that can decrease mortality are (CBM)
metoprolol, Bisoprolol Carvedilol | depending on Bld pressure
199
Aldo blocker decrease cardiac fibrosis
Eplerenone spironolactone | aldo increase d/to RAAS and sympathetic
200
Block ADH with
Conivaptan Tolvaptan
201
autoimmune attack against acetylcholine nicotinic receptor
40% thymoma MG | test with edrophonium
202
# acetylcholinesterase inhibitor first line treatment for MG
neostigmine
203
irreversible ACHesterase Inhibitor
parathion, malathion
204
# anticholinergics DOC for organophosphate poisoning
Atropine pralidoxime(2 PAM)
205
# anticholinergics use to dry up pulmonary secretion before surgery
Glycopyrrolate
206
# anticholinergics use for Parkinson DZ or for dystonia
Benztropine Trihexyphenidyl
207
# anticholinergics treatment for COPD
IPratropium tiotropium
208
mucolytic
Guaifenesin N-acetylcysteine | best for COPD
209
decrease mortality after MI
Nitrites in blacks Sacubitral Morphine Beta blocker (avoid with hypo-TN) Statin ACEI/ARB Spironolactone Aspirin +ADP inhibitors (ticagrelol…)
210
decrease mortality with hypertrophic cardiomyopathy
spironolactone
211
decrease mortality in acute MI
tPA Heparin Aspirn + Clopidagrel stop metformin stop CCB
212
mood-stabilizing agents
Lithium anticonvulsants valproate, carbamazepine, and lamotrigine
213
MOA of Tamoxifen and Raloxifene
competitive inhibitor of estrogen binding mixed agonist/antagonist action
214
Treatment for postmenopausal osteoporosis
Raloxifene
215
adjuvant treatment of breast cancer Endometrial hyperplasia uterine sarcoma
Tamoxifen
216
2 NRTIs ( nucleoside reverse transcriptase inhibitors) converte by a cellular kinase to monophosphate
Zidovudine Emtricitabine
217
2 NNRTIs (Nonnucleoside RTI) no intracellular phosphorylation needed
Nevirapine efavirenz
218
HIV protease inhibitor
'navir". Ritonavir
219
treatment of anogenital warts cuased by HPV
Topical imiquimod
220
block Na ion conduction paralysis and kill louse
permethrin phthirus pubis(Crabs)
221
bipolar maintenances
lithium valproate lamotrigine Second gen antipsychotics quetiapine risperidone
222
MOA of Rasburicase
converts uric acid into more soluble metabolites
223
a purine inhibitor of xanthine oxidase
Allopurinol
224
a non-purine inhibitor of xanthine oxidase | fewer adverse effects
Febuxostat
225
supply thio group to inactivate toxic metabolites
Mesna
226
indication for Dobutamine | increase O2 demand
refractory systolic dysfunction and cardiogenic shock | positie inotropy and chronotropy and mild vasodilation
227
Anthracyclines( daunorubicin, doxorubicin) moa
binding to the topoisomerase II enzyme in cancer cells DNA intercalating:cleavage complexes that break DNA Free radical formation
228
dexrazoxane
Prevent cardio toxicity (dilated cardiomyopathy)
229
tazobactam, clavulanic acid, and sulbactam moa
Prevents beta lactamase
230
Proton pump inhibitors (eg, omeprazole, lansoprazole) block
H+/K+-ATPase proton pump
231
human epidermal growth factor receptor 2 (HER2) drug
Trastuzumab
232
decrease mortality in heart failure
BASS N Beta Blocker ACEI/ARBs Spironolactone Statin Sacubutril Nitrites in blacks
233
ADHD | Preferred med’
Stimulants (methylphenidate, amphetamine) | Preferred med’
234
Alcohol withdrawal
Benzo’s(chlordiazepoxide,lorazepam, diazepam) | Preferred med’
235
Bipolar disorder | Preferred med’
Lithium, valproic acid, atypical antipsychotics
236
Bulimia nervosa Rx
SSRIs
237
Depression RX
SSRIs
238
GAD General Anxiety Disorder
SSRIs, SNRIs
239
OCD rx
SSRIs, venlafaxine, clomipramine
240
Panic disorder
SSRIs, venlafaxine, benzo’s
241
PTSD
SSRIs, venlafaxine
242
Schizophrenia
Atypical antipsychotics
243
Social anxiety disorder
SSRIs, venlafaxine Performance only: ß-blockers, benzo’s
244
Tourette syndrome
Antipsychotics (fluphenazine,pimozide, tetrabenazine)
245
CNS stimulants
Methylphenidate Dextroamphetamine Methamphetamin
246
CNS stimulants moa
increase catecholamines: NE & Dopamine
247
Uses for CNS stimulants
ADHD Narcolepsy Appetite control
248
Antipsychotics (neuroleptics) Haloperidol + “azines MOA
block D2 receptors(increase cAMP)
249
Hi Potency Antipsychotics (neuroleptics)
Trifluoperazine Fluphenazine Haloperidol
250
adverse effect of Hi potency D2 blocker
EPS
251
2 low potency antipsychotic
chlorpramazine Thioridazine
252
block alpha 1, decrease BP, corneal deposits
chlorpromazine
253
Thioridazine : can cause
iris pigmentation (ReTinal deposits)
254
Haloperidol causes
NMS, Tardive dyskinesia
255
EPS that starts hrs to days
Acute dystonia Muscle spasm, stiffness oculogyric crisis
256
EPS that starts months later
Akathisia Parkinsonism
257
EPS that starts months to years
Tardive dyskinesia
258
NMS (FEVER)
fever encepholopathy vitals unstable Enzymes increase Rigidity
259
antipsychotics are water soluble or fat soluble
260
Treat EPS with
Benztropine Diphenhydramine Benzodiazepines
261
NMS treatment
Dantrolene D2 agonist(bromocriptine)
262
depot form antispychotic
Fluphenazine | EPS
263
Promethazine
anti-emetic in children | EPS
264
adult antiemetic
perchlorperazine | EPS
265
MOA of atypical antipsychotics
Most are D2 antagonists varied effects on 5-HT2, dopamine + ⍺ and H1 receptor
266
# atypical Aripiprazole moa
D2 partial agonist
267
indication of atypical antipsychotic
schizophrenia: both + & – sx * bipolar disorder * OCD * anxiety disorder * depression * mania * Tourette syndrome
268
Effect of atypical antipsychotics
prolonged QT Metabolic syndrome
269
2 failed antipsychotic.. next step
clozapine
270
adverse effect of clozapine
agranulocytosis Neutropenia Seizures
271
Olanzapine causes
Obesity
272
Risperidone SE
hyperprolactinemia (amenorrhea, galactorrhea, gynecomastia)
273
Quetiapine SE
catatacts
274
blocks dephosphorylation of IP3-DA | mood stabilizer
Lithium
275
Lithium indication
mood stabilizer for bipolar disorder blocks relapse + acute manic events
276
Lithium causes
tremor Nephro DI Hypothyroidism teratogenic
277
other drug thats implicated in Lithium tox
thiazide
278
Epsteins anomaly(atrialization)
Lithium in pregnacy
279
GAD, no sedation, ++5-HT-1A receptors
Buspirone
280
5-HT-specific reuptake inhi
SSRIs
281
SSRIs list
sertraline citalopram fluoxetine paroxetine
282
hyperthermia confusion diarrhea seizures cardiovascular collapse
serotonin syndrome
283
SSRI indication
use: * depression * GAD * panic disorder * OCD * bulimia * social anxiety disorder * PTSD * premature ejaculation * premenstrual dysphoric disord
284
sertraline use in
PTSD
285
fluoxetine(prozac)
depression
286
helps with memory post stroke
escitalopram
287
social phobia premature ejaculation
Paroxetine
288
Rx for serotonin syndrome
cyproheptadine
289
SNRI
Venlafaxine Desvenlafaxine Duloxetine Levomilnacipran Milnacipra
290
Inhibit 5-HT + NE reuptake
SNRI
291
# indication SNRI
depression GAD diabetic neuropathy
292
venlafaxine indication
Social anxiety disorder. panic disorder * PTSD * OCD
293
Duloxetine indication
depression peripheral neuropathy
294
how to prevent arrhythmia in TCA tox
NaHCO3
295
MAOi-B action
nonselective MAOi ↑ levels of amine NT’s (NE, 5-HT, dopamine)
296
MOAi indication
* Atypical depression * Anxiety
297
MAOi S/E
* HTN crisis (most notably w/ tyramine containing foods) * CNS stimulatio
298
# Atypical antidepressants Buproprion MOA
* ↑ NE + Dopamine via unknown mechanism * smoking cessation
299
Mirtazapine MOA
* ⍺2-antagonist (↑ NE + 5-HT) * potent 5HT2 + 5HT3 receptor antagonist * H1 antagonist | depression
300
Mirtazapine toxicity
* sedation (desirable in insomnia pt) * ↑ appetite / weight gain (desirable in elderly /anorexic pt) * dry mouth
301
Trazodone toxicity | Blocks: 5-HT2, A1, H1
priapism Sedation
302
Nicotinic ACh receptor partial agonis
Varenicline | smoking cessation
303
MOAi -A
Tranylcypromine Isocarboxacid Phenelzine
304
use for out patient empiric treatment of uncomplicated pyelonephritis
Fluoroquinolones (ciprofloxacin 7days levofloxacin 5days
305
a non stimulent drug for ADHD child used in pt with a family history of drug abuse
atomoxetine moa: selective norepinephrine reuptake inhibitor
306
moa of modafinil (used sometimes for off-label ADHD treatment)
weak dopamine transport inhibitor
307

Step 1 Clues (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions