Pharm: Migraine Meds Flashcards Preview

Clinical Neuro Exam 1 > Pharm: Migraine Meds > Flashcards

Flashcards in Pharm: Migraine Meds Deck (25):
0

Ibuprofen

Used for moderate migraine pain

MOA: increases pain threshold by decreasing prostaglandin synthesis

SE: ulcers, GI bleeding, rebound headaches

1

Indomethacin

Used for moderate migraine pain

MOA: increases pain threshold by decreasing prostaglandin synthesis

SE: ulcers, GI bleeding, rebound headaches

2

Aspirin

Used for moderate migraine pain

MOA: increases pain threshold by decreasing prostaglandin synthesis

SE: ulcers, GI bleeding, rebound headaches

3

Naproxen

Used for moderate migraine pain

MOA: increases pain threshold by decreasing prostaglandin synthesis

SE: ulcers, GI bleeding, rebound headaches

4

Sumatriptan

Used for acute migraine headaches

MOA: 5HT1 agonist
-stimulate vasoconstriction of basilar artery and dura mater vessels
-block proinflammatory NTs like CGRP and substance P around the trigeminal nerve

SE: serotonin syndrome

5

Zolmitriptan

Used for acute migraine headaches

MOA: 5HT1 agonist
-stimulate vasoconstriction of basilar artery and dura mater vessels
-block proinflammatory NTs like CGRP and substance P around the trigeminal nerve

SE: serotonin syndrome

6

Naratriptan

Used for acute migraine headaches

MOA: 5HT1 agonist
-stimulate vasoconstriction of basilar artery and dura mater vessels
-block proinflammatory NTs like CGRP and substance P around the trigeminal nerve

SE: serotonin syndrome

7

Codeine

Opioid
Used for mild to moderate pain
Used for migraines in patients that cannot tolerate triptans

MOA: metabolized to morphine for a weaker effect. Agonist at mu, kappa, and delta receptors

SE: addiction

8

Morphine

Opioid
Used for severe pain or severe migraine headaches in patients that cannot tolerate triptans

MOA: agonist at mu, kappa, and delta receptors

SE: addiction

9

Dexamethasone

Corticosteroid
Used in combination with other drugs as a pain reliever.

MOA: inhibition of phospholipase A for anti-inflammatory effects

SE: steroid toxicity

10

Caffeine

Xanthine Alkaloid
Used for headaches, usually in combination with acetaminophen, aspirin for moderate migraine pain.

MOA: inhibits phosphodiesterase leading to increased cAMP levels

SE: insomnia, agitation, restlessness

11

Acetaminophen

Used when aspirin is contraindicated.
Combined with isometheptene and dichloralphenazone for moderate headaches
Combined with butalbital for infrequent headaches with moderate to severe intensity (GABAmimetic)
!!!!!this and opioids are only viable option during pregnancy!!!

MOA: COX inhibitor without the anti-inflammatory effects

SE: toxic to liver in high continued doses

12

Propranolol

Migraine Prophylaxis that inhibits sodium channels within membranes of neurons to prevent firing of pain signals

MOA: non-selective beta blocker

13

Verapamil

Migraine Prophylaxis, relieves symptoms of aura

MOA: calcium channel blocker

14

Lisinopril

Reduces duration and severity of migraines by keeping BP down

MOA: ACE inhibitor

15

Amitriptyline

Migraine prophylaxis

MOA: 5HT and NE reuptake inhibitor

SE: AV bundle branch block, anorexia, blurred vision, dry mouth, constipation, sedation, weight gain, may precipitate MANIA in BIPOLAR disorders

16

Nortriptyline

Migraine prophylaxis

MOA: 5HT and NE reuptake inhibitor

SE: AV bundle branch block, anorexia, blurred vision, dry mouth, constipation, sedation, weight gain, may precipitate MANIA in BIPOLAR disorders

17

Pizotifen

Prophylaxis for recurrent migraines when beta-blockers are contraindicated.

MOA: 5HT2 antagonist and moderate histamine and cholinergic antagonist

SE: weight gain, drowsiness

18

Topiramate

Anti-seizure meds and migraine prophylaxis

MOA: voltage gated sodium channel inhibitor, AMPA/kainate inhibitor, calcium channel inhibitor

SE: increased IOP, poor concentration, weight loss, induces P450 enzymes in liver

19

Valproate (ionized form of valproic acid)

Used for seizures and migraine prophylaxis

MOA: enhances GABA transmission, inhibits sodium channels and T type calcium channels

SE: weight gain, fetal abnormality, hair loss, tremor

20

Gabapentin

Used for partial seizures and neuroleptic pain

MOA: analog of GABA, inhibits voltage calcium channels

SE: dizziness, sedation, peripheral edema

21

Botulinum Toxin

Used for chronic migraines in adults

MOA: inhibits SNAP-25, a snare protein required for vesicles containing neurotransmitters to bind and release contents into the synapse

SE: reversible paralysis

22

Chlorpromazine

Used as an antiemetic, for schizophrenia, Tourette syndrome, huntington chorea, dementia

MOA: anticholinergic, anti-dopaminergic, anti adrenergic, anti histaminergic

SE: phototoxicity, blurred vision, constipation

23

Prochlorperazine

Used as an antiemetic, for schizophrenia, Tourette syndrome, huntington chorea, dementia

MOA: anticholinergic, anti-dopaminergic, anti adrenergic, anti histaminergic

SE: blurred vision, constipation, amplifies quinidine mediated cardiotoxicity, weakly diuretic

24

Metoclopramide

Used for migraines, gastric stasis, stimulate lactation

MOA: D2 and 5HT3 antagonist, agonist at 5HT4

SE: galactorrhea, extrapyramidal effects, tardive dyskinesia

Not to be used in patients with pheochromocytoma or Parkinson disease