Flashcards in Path: Neoplasms Deck (22):
Describe the location and age group associated with fibrillary astrocytomas.
Found in cerebral cortex gray matter NOT well circumscribed.
Found in adults (3rd or 4th decade)
Describe the location and age group associated with a glioblastoma.
Found in cerebral cortex gray matter, WELL circumscribed.
Seen in older patients
Describe the location and age group associated with a pilocytic astrocytoma.
Found in the cerebellum
Seen in young children
Describe the symptoms associated with a brainstem glioma and the age group that most commonly develops them.
Dysphonia, ataxia, facial paralysis, extraocular eye muscle weakness,
Seen in young children (first 2 decades)
Describe the location and age group associated with oligodendriogliomas.
Found in the cerebral hemisphere white matter. Associated with calcifications.
Seen in young to middle aged adults.
Describe the location and age group associated with ependymomas.
In children: located near 4th ventricle, can lead to hydrocephalus
In adults: located in the spinal cord
What is the name for the ependymoma that forms in the filum terminale?
Describe the location and age group associated with colloid cysts.
Located in the roof of the 3rd ventricle resulting in a non-communicating hydrocephalus.
Seen in young adults.
Describe the location and age group associated with a central neurocytoma.
Located in lateral and 3rd ventricles.
Seen in young adults.
Describe the location and age group associated with medullablastomas.
In children: located in vermis of cerebellum
In adults: located in lateral medullaru region of cerebellum
If a child presents with gait problems and vertigo, what are the two tumors on the DDx and how do you distinguish them?
1. Pilocytic Astrocytoma
What is the most common primary intracranial neoplasm found in immunocompromised patients?
Primary CNS lymphoma
Describe the location and age group associated with primary CNS lymphomas.
Seen in the cerebral hemispheres (supratentorial) and can spread across the corpus callosum.
Seen in patients usually over 60 years
Describe the location and age group associated with craniopharyngeomas.
Seen above sella turcica. Compresses pituitary gland and optic chiasm leading to endocrinopathies and tunnel vision.
Bimodal age distribution:
-young (10-14 yrs.)
-old (7th decade)
calcifies (just like oligodendriogliomas)
Most common sites where metastatic brain tumors originate.
Lung, breast, skin, kidneys, GI
What is a paraneoplastic syndrome and name the 5 most common syndromes.
Host immune system reacts to an invading pathogen that ressembles CNS or PNS tissue and the resulting defense attacks the host tissue.
-eye movement disorders
- limbic system
- sensory neuropathy
Most common schwannoma.
Acoustic Neuroma (CN VIII)
Describe von Hippel Lindau Disease.
Autosomal Dominant hemangioblastoma that arises in the cerebellum or retina.
Can result in polycythemia due to dysregulation of erythropoietin.
von Hippel Lindau Disease results in an increased risk of developing which 2 conditions?
1. Renal Cell Carcinoma
What is Tuberous Sclerosis and what are the two major signs and symptoms?
Autosomal dominant disease with growth of multiple benign neoplasms in the cortex.
Occurs mostly in children.
-seizures and epilepsy
What are Lisch Nodules?
Melanocytic hamartomas that form in the iris in patients with Neurofibromatosis.