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Flashcards in Pharmacology Deck (12)
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1

Pharmacology of Spironolactone

Spironolactone = K-sparing diuretic. Structurally similar to aldosterone :. blocks aldosterone.

Acts on the DCT and CD

2

Pharmacology of Aspirin

What does it inhibit? Where does it act?

Aspirin = COX inhibitor

Inhibits cyclooxygenase enzymes in the PCT

3

Pharmacology of Amlodipine

Amlodipine = CCB

Inhibits L-type voltage gated Ca channel in the nephron

4

Pharmacology of Bendroflumethiazide

Bendroflumethiazide = thiazide diuretic

Inhibits Na-Cl transporter in DCT

5

Pharmacology of Furosemide

Furosemide = Loop diuretic

Acts on Ascending LoH. Inhibits Na/K/Cl transporter

6

Methotrexate can be used to treat a) and b)

a) Rheumatoid Arthritis

b) Psoriasis

c) Crohn's

d) NHL, ALL

7

Pharmacology of NSAIDs

Example

Non-selective inhibitor of COX-1 and COX-2

Eg NAPROXEN

8

Pharmacology of Bisphosphonates

Example

Inhibit Osteoclast-mediated resorption

Alendronate

9

Methotrexate pharmacology

Uses

Contraindications

Inhibits dihydrofolate reductase

DHF reductase usually converts folic acid > F4, which is needed for DNA + protein synthesis

Uses = IMMUNOSUPPRESSANT DMARD
- Rheumatoid arthritis
- Psoriatic arthritis
- Crohn's
- Cancer (ALL, NHL)

Contraindicated in pregnancy. Alternative = Sulfasalazine + Folic Acid

10

Carbimazole side effect

Agranulocytosis

11

Gentamicin side effect

Ototoxicity

- toxicity to bones of ear

12

Beta Blockers pharmacology

Block beta-1 muscarinic receptors in the myocardium > reduce rate + force of contraction

Block Beta-2 receptors in smooth muscle vessels + airways > cause vaso/airway constriction (CI in asthma)