Flashcards in ICS Pathology Deck (23)
Action of drug on body
Action of body on drug
Anticholinergics decrease the effect of the ___ nervous system.
- blurred vision
- dry mouth
- urinary retention
What drugs inhibit bacterial cell wall synthesis?
Penicillin + Cephalosporins + Carbapenems + Glycopeptides
What drugs inhibit DNA replication/ transcription?
Quinolones - Ciprofloxacin
Which drug inhibits COX?
Pharmacology of Warfarin
Vitamin K antagonist > prevents synthesis of vitK-dependant clotting factors (2, 7, 9, 10)
Green leafy veg = source of VITK
Grapefruit, cranberries, alcohol INCREASE warfarin effect.
Co-amoxiclav is a combination of...
Amoxicillin and Clavulanic acid (B-lactamase inhibitor)
What is a phaeochromocytoma?
Tumour of the adrenal medulla's chromaffin cells
Releases catecholamines (adrenaline)
What is the risk of removing a phaeochromocytoma?
Removal > large release of catecholamines > refractory hypertension
What measurements do we take prior to removing a phaeochromocytoma?
Alpha then Beta Block
Phenooxybenzamine then Bisoprolol
(If beta blocked first > Blocked B2-vasodilation > uncontrolled A1-vasoconstriction > refractory HTN)
What is Carbimazole used for?
Where does C. diff colonise?
Pseudomembranous colitis caused by...
Ischaemic colitis caused by...
Associated with AF.
Mycobacterium Avium Complex causes ___ which is an __-defining illness
Mycobacterium avium-intracellular infection = AIDS-defininf illness
Atypical pneumonia causes associated with animals?
Chlamydia psittaci - birds
How do we treat pulmonary TB?
SE of tx?
Rifampicin: red/orange urine/tears
Isoniazide: Peripheral neuropathy
Ethambutol: colour blindness, reduced visual acuity
Cells involved in Inflammation
Neutrophil polymorph - phagocytic
Macrophage - Ag-presenting
Lymphocytes - Specific Ags
Endothelial cells - sticky, porous, angiogenesis
Fibroblasts - collagen repair
Inflammation cardinal signs
Atherosclerosis pathophysiology outline.
Inflammatory cytokines involved?
Atherosclerotic plaque composition.
Ox-LDL + Macrophage = Foam cell > trapped in tunica intima > die > release fat > fatty core
IL 1, 6, 8
Atherosclerotic plaque = Fibrous tissue + lipid + lymphocytes + Necrotic Core.
Lesion from autonomous growth of cells which persists after the stimulus is removed.