Physiological psychology and psychopharmacology Flashcards
(80 cards)
List the sedative hypnotics
These drugs are generalized CNS depressants and are dose dependent ?
List Beta Blockers and what is the purpose
List Narcotic-Analgesics and purpose
Barbiturates, anxiolytics, alcohol
Low dose: reduce arousal and motor activity,
Moderate: sedation and sleep
High Dose: anesthesia , coma and death
Beta Blockers- Propranolol (Inderal) treat cardiovascular disorders and physical symptoms of anxiety
Narcotic-Analgesic: natural opioids (opium, morphine, codeine) semisynthetic derivatives of morphone ( heroine, Percodan, Dilaudid and pure synthetics (Demerol, Darvon, Methadone)- naturally occurring in the body-endorphins and enkephalins
List the Antidepressant Drugs.
How do they work and what do they treat?
- Tricyclic : Blocks the reuptake of Norepinephrine, Serotonin and dopamine supports the catecholamine hypothesis
treats: alleviate vegetative symptoms of depression, panic D/O, Agoraphobia, Bulimia Nervosa, OCD (clomipramine) enuresis (imipramine) neuropathic pain (amitriptyline and nortriptyline)
-SSRI (selective Serotonin reuptake inhibitors)
Block reuptake of serotonin
melancholic depression, OCD, Bulimia, Panic D/o and PTSD (common: fluoxetine, fluvoxamine, paroxetine and sertraline)
-MAOI (monoamine oxidase inhibitors):
inhibits MAOI which is involved in deactivating dopamine, norepinephrine, and serotonin
non-endogenous and atypical depression that involves anxiety and vegetative symptoms. and interpersonal sensitivity
What is the oldest and most widely used drug to treat neuropathic pain?
Neuropathic pain is chronic pain that is due to a nervous system injury or dysfunction. The first-line treatments for neuropathic pain are analgesics, which include certain antidepressants, anticonvulsants, opioids, and local anesthetics.
– Antidepressant drugs that increase levels of both serotonin and norepinephrine not only reduce the depression that often accompanies neuropathic pain but also have analgesic properties. The tricyclic amitriptyline is one of the oldest and most widely used tricyclic drug for neuropathic pain.
Abnormalities in which of the following areas of the brain have been linked to ADHD, OCD, and Tourette’s Disorder?
The basal ganglia include the caudate nucleus, putamen, and globus pallidus and are involved in the planning, execution, and speed of motor activity. Abnormalities in the basal ganglia have been linked to the disorders listed in this question.
A person with a brain injury is exhibiting unilateral neglect when he or she:
Unilateral neglect refers to impaired spatial awareness on one side of the body. People with unilateral neglect ignore objects on the affected side of the body (e.g., food on one side of their plate) and fail to groom and dress that side of the body.
Unilateral neglect is usually caused by damage to the right parietal or right parietal-occipital area and involves a lack of awareness of objects, people, and stimuli on the opposite (left) side of the body. (In this situation, it is also known as contralateral neglect.)
The James-Lange theory is classified as a peripheralist theory of emotion. He emphasized the role of ?
visceral and muscular reactions. Peripheral factors - emotions represent perception to bodily reactions to sensory stimuli
According to the James-Lange theory, “we are afraid because we run.” In other words, emotions are perceptions of bodily reactions
Describe Akathisia
Dystonia
Akinesia
-Akathisia is an extrapyramidal side effect of the neuroleptic drugs and a symptom of Parkinson’s disease and involves an unpleasant feeling of restlessness and need to move.
-Dystonia: Spasmas and contortions
Akinesia motor and psychic hypoactivity
Diabetes is associated with rapid changes in blood glucose levels and there is some evidence that these fluctuations are associated with ?
For some patients with type 2 diabetes, acute hyperglycemia can produce: Hyperglycemia refers to elevated blood glucose levels. There is evidence that, for some patients with type 2 diabetes, acute hyperglycemia produces substantial impairments in speed of information processing, working memory, and some aspects of attention as well as decreased happiness and alertness and increased agitation.
What hormones play a role in the sexual arousal of males and females?
Androgen
The research suggests that estrogen plays an insignificant role in female sexual motivation and arousal and that androgen, which is produced by the adrenal cortex, plays an important role in the sexual functioning of both males and females
What are the symptoms in hyperthyroidism?
What are the symptoms in hypoglycemia?
difficulties in concentration, forgetfulness, sensitivity to cold, unexplained weight gain and constipation
hypoglycemia: weakness, headache, hunger, and anxiety The symptoms of hypoglycemia include headache, dizziness, sweating, impaired concentration, confusion, clumsy or jerky movements, weakness, and, in extreme cases, convulsions or a loss of consciousness. is the result of low levels of blood glucose.
What is true about retrograde amnesia caused by moderate to severe head trauma?
Head trauma is most likely to affect more recent long-term memories. When memories begin to return, however, those that are most remote are recovered first. For example, if you forget everything that happened to you during the year prior to a head trauma, once you begin to recover your “lost” memories, you will first recall things that occurred 12 months prior to the trauma, than 11 months prior to the trauma, and so on.
The most recent memories are most vulnerable to amnesia but more remote memories are the first to be recovered. - you lose it and then you remember it as you lived it, from start to end
When is brain laterization for language first evident?
Brain lateralization refers to the process in which different functions become specialized in one of the two hemispheres of the cerebral cortex.
The research suggests that brain lateralization is already evident in the first few months of life. For example, there is evidence that newborns show greater electrical activity in the left hemisphere than in the right hemisphere in response to speech sounds.
What is the treatment for alcohol addiction?
And how does it work.
Disulfiram (Antabuse) inhibits alcohol metabolism causing an accumulation of acetaldehyde and unpleasant reactions (severe nausea, vomiting, sweating, headache
Naltrexone is an opioid receptor antagonist that blocks the craving for and reinforcing effects of alcohol
Migraines are most common in ___ and linked to the personality trait_____
The risk for migraine is higher for females than males; the onset of migraines is between puberty and mid-life; and personality characteristics that have been linked to migraines include perfectionism, neatness, restraint, and ambitiousness.
This Neurotransmitter is found in the peripheral nervous system, the spinal cord, and certain regions of the brain. In the peripheral nervous system, it activates both muscles and glands. The venom of the black widow spider is believed to work by causing a continuous flow of ___________ into the neuromuscular junction, resulting in uncontrollable muscle contractions
acetylcholine
Fluoxetine and other SSRIs act by
SSRI stands for selective serotonin re-uptake inhibitor, which means that the SSRIs exert their effects by reducing the uptake of serotonin at nerve synapses, thereby increasing their availability.
Teratogens can have a negative effect on fetal development during the entire pregnancy, but their consequences are much more severe during critical periods of development when the organ system is growing most rapidly. The critical period varies from organ to organ, but generally occurs within the first ____ weeks of development. (An exception is the central nervous system, which has a critical period that extends into the _____ week of development.)
8 weeks 2m (1st trimester = 1 to 13)
16 week 4 m (2nd = 14 to 27 wks. )
Research using neuroimaging techniques has pinpointed the location of specific emotional and behavior changes caused by frontal lobe damage.
Damage to the orbitofrontal areas produces what?
Damage to the medial frontal area?
Damage to the anterior cingulate area ?
Damage to the dorsolateral prefrontal area produces?
Damage to the orbitofrontal areas produces pseudopsychopathy (disinhibition and impulsive behavior), euphoria, lack of judgment and social tact, and distractibility. (around the orbit you get fake crazy)
medial frontal area produces akinesia, mutism, and weakness and loss of sensation in the lower extremities. (mute in the middle)
Damage to the anterior cingulate area is associated with apathy and paucity of speech and movement.
Damage to the dorsolateral prefrontal area produces impaired executive functioning, slowed information processing, and mood and personality changes (personality doros)
s a treatment for alcohol dependence, naltrexone exerts its therapeutic effects by blocking the craving for and reinforcing effects of alcohol.
What are the potential side effects of naltrexone. Note, however, that most people experience few side effects when taking naltrexone as a treatment for alcohol dependence.
What are the side effects of carbamazepine, an anti-seizure drug that is also used to treat bipolar disorder.
What are the possible side effects of the MAOI inhibitors.
What the are possible side effects of the beta blocker propranolol?
Naltrexone: abdominal cramping, nausea, insomnia, nervousness, and headache
Carbamazepine: dizziness, ataxia, visual disturbances, nausea, and rash
MAOI inhibiters: . blurred vision, sexual dysfunction, weight gain, edema, and tremor
Propranolol shortness of breath, increased dreaming, nausea, diarrhea, and bradycardia
What is responsible for the body’s fight or flight?
The term “fight or flight” refers to the response of the glands and smooth muscles to dangerous or emergency situations.
It is the sympathetic branch of the autonomic nervous system that is responsible for the body’s fight or flight reaction (e.g., increased heart rate, cessation of digestive processes).
HM went through bilateral medial temporal lobectomy as a treatment for severe epilepsy. What happened as a result?
While H.M.’s short-term and remote long-term memory were intact, he was unable to form new long-term memories and had trouble retrieving information from recent long-term memory.
Glutamate acts as what? and plays a role in? when excessive what happens?
Glutamate acts as an excitatory neurotransmitter in the brain and spinal cord. It’s known to play a role in learning and memory, including long-term potentiation (LTP) which is a brain mechanism that’s believed to be responsible for the formation of long-term memories. There’s also evidence that excessive glutamate receptor activity (“excitotoxicity”) contributes to stroke-related brain damage, Huntington’s disease, Alzheimer’s disease, and other neurodegenerative disorders.
Renal failure is also known as kidney failure and occurs when the kidneys are no longer able to remove waste from the body and maintain a normal level of electrolytes in the bloodstream. However, in many cases, the initial symptoms are a change in the amount and frequency of
urination and discomfort or pain when urinating. The change can involve an increase in urination (polyuria) with urine being paler than usual or a decrease in urination (oliguria) with urine being darker than usual.
- The ___________cortex contains the secondary and tertiary olfactory cortical areas and is involved in the conscious perception of odors; while the ______ plays an important role in olfactory memory.
- The ________ cortex (insula) is part of the limbic system and is involved in emotions and pain. The ____ is also part of the limbic system; it controls emotions and has been identified as a “pleasure area” of the brain.
- The ______ cortex is located in the parietal lobe and processes information related to touch. Also, olfaction is the only sensory system that does not send incoming signals directly to the ___________.
- The _____cortex is part of the limbic system and has been linked to several functions including pain perception and reward-based decision making. The _______is part of the hindbrain and mediates vital bodily functions such as breathing and heartbeat
- orbitofrontal: amygdala
- The insular : septum
- somatosensory: thalamus
- cingulate: Medulla