Protein Degradation Flashcards Preview

Biochemistry 431 > Protein Degradation > Flashcards

Flashcards in Protein Degradation Deck (4)
1

E1

ubiquitin-activating enzyme; ATP - dependent enzyme, activates ubiquitin,

2

E2

ubiquitin-carrier protein - brings ubiquitin to E3

3

E3

ligase - adds ubiquitin to protein desired for degradation.

4

Process of ubiquination

1) E1 activating enzyme; forms thioester bond with C-terminal of gly of ubiquitin 2) Ubiquiting is transferred to a cys-thiol of E2, the ubiquitin carrier protein 3) E3 ligase selects proteins for degradation. the E2-S-ubiquitin complex transfers ubiquitin to lys of selected proteins.

Decks in Biochemistry 431 Class (80):