RNA interference RNAi by miRNA Flashcards Preview

Biochemistry 431 > RNA interference RNAi by miRNA > Flashcards

Flashcards in RNA interference RNAi by miRNA Deck (4)
1

pri-mRNA

folds into a stem-loop structure

2

pri-mRNA modification

5' and 3' extensions removed from pri-mRNA by the microprocessor complex (Drosha + DGCR8) forming 3'-OH and 5' monophosphate

3

Pre-mRNA

formed once 5' and 3' extensions are removed by the microrepressor complex. features 3'-OH and 5' monophosphate

4

PAZ domain

Present on the dicer complex; binds to the 3' end of the hairpin and dicer cleaves the pre-miRNA to produced miRNA

Decks in Biochemistry 431 Class (80):