Flashcards in EC Paper Deck (6)
is a universally conserved P-loop GTPase that acts at the crossroads of the major cellular processes of translation and DNA replication, processes thought to be repressed in dormant persister cells; y, it plays a role in DNA replication initiation, replication fork stabilization, and ribosome maturation, processes
that are targeted by many antibiotics
Deletion of RelA and SpoT
results in a dramatic decrease in HipA-mediated persistence.
high cellular levels of (p)ppGpp
were recently demonstrated to activate TA modules through a regulatory cascade depending on inorganic
polyphosphate and the Lon protease
global control of persistence in E. coli through
Obg-mediated persistence requires
(p)ppGpp and proceeds via transcriptional activation of the
type I hokB-sokB TA module, ultimately resulting in a decrease
in membrane potential.