Covalent Attachments of lipids Flashcards Preview

Biochemistry 431 > Covalent Attachments of lipids > Flashcards

Flashcards in Covalent Attachments of lipids Deck (5)
1

What is the purpose of attaching lipids to proteins?

typically to target proteins to the cell membrane.

2

Acylation

addition of fatty acid groups; myristoyl (N of glycine) and palmitoyl groups (cysteine of C terminus) ; myristoyl strong bond

3

Prenylation

addition of an isoprenoid group; strong; GTP binding proteins involved in signaling

4

GPI anchors

weak; phosphatodylinositol + glycan +lipid group

5

Ras

Signaling GTPase; both farnesylated and palmitoylated; if both are present goes to cell membrane; if only farnsylated, golgi body.

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