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Flashcards in RSL - Haem Deck (57)
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1

Anisocytosis

Varying sizes

2

Poikilocytosis

Varying shapes

3

Dense granules (platelets)

ADP, Ca++

4

Alpha granules (platelets)

vWF, Fibrinogen

5

Specific granules (neutrophils)

ALP, collagenase, lysozyme, lactoferrin

6

Azurophilic granules (neutrophls; lysosomes)

Proteinases, acid phosphatase, myeloperoxidase, beta-glucuronidase

7

Neutrophil chemotactic factors

C5a, IL-8, LTB4, Kallikrein, platelet-activating factor

8

Frosted glass cytoplasm

Monocyte

9

Eosinophil products

Major basic protein and histaminase

10

Basophillic granules (Basophils)

Densely packed with histamine and hepararin

11

IgE crosslinking on mast cells -->

Release of contents: Histamine, heparin, eosinphilic chemotactic factors

12

Cromolyn Sodium

Prevents mast cell degranulation

13

Thrombomodulin-thombin complex

--> Activates protein C which binds Protein S --> Factor Va / VIIIa cleavage

14

Factor XIIIa

Stabolizes fibrin meshwork

15

Vitamin K is needed for:

II, VII, IX, X

16

Requires Ca++

V, VIII, VII

17

vWF is from?

Weibel-palade bodies of endothelial cells and alpha granules of platelets

18

Platelet plug formation: 1. injury

endothelial damage --> transient vasoconstriction via neural stimulation reflex and endothelin (released from damaged cell)

19

Platelet plug formation: 2. Exposure

vWF binds collagen

20

Platelet plug formation: 3. Adhesion

Platelets bind vWF via Gp Ib --> conformational change --> dense granule release (ADP/Ca++ --> coagulation), TXA2 --> platelet aggregation

21

Platelet plug formation: 4. Activation

ADP binding receptor --> Gp IIb/IIIa expression

22

Platelet plug formation: 5. Aggregation

Fibrinogen binds Gp IIb/IIIa linking platelets

23

Acanthocyte

Liver disease, abetalipoproteinemia (cholesterol dysregulation): Spiny cell

24

Basophillic stippling

Lead poisoning

25

Degmacyte

Bite cell; G6PD deficiency

26

Target cell

HbC disease, asplenia, Liver disease, thalasemia

27

Heinz bodies

Oxidation of Hb-SH groups to S--S --> Hb precipitation --> phavocytic damage to RBC membrane --> bite cells. Seen in G6PD deficiency, and alpha thalasemia

28

Howell jolly bodies

Basophillic remnants found in RBCs.

29

Iron absorption state

Fe3+

30

Ferroportin

brings Iron into blood -->transferrin