Flashcards in RSL - Haem Deck (57)
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1
Anisocytosis
Varying sizes
2
Poikilocytosis
Varying shapes
3
Dense granules (platelets)
ADP, Ca++
4
Alpha granules (platelets)
vWF, Fibrinogen
5
Specific granules (neutrophils)
ALP, collagenase, lysozyme, lactoferrin
6
Azurophilic granules (neutrophls; lysosomes)
Proteinases, acid phosphatase, myeloperoxidase, beta-glucuronidase
7
Neutrophil chemotactic factors
C5a, IL-8, LTB4, Kallikrein, platelet-activating factor
8
Frosted glass cytoplasm
Monocyte
9
Eosinophil products
Major basic protein and histaminase
10
Basophillic granules (Basophils)
Densely packed with histamine and hepararin
11
IgE crosslinking on mast cells -->
Release of contents: Histamine, heparin, eosinphilic chemotactic factors
12
Cromolyn Sodium
Prevents mast cell degranulation
13
Thrombomodulin-thombin complex
--> Activates protein C which binds Protein S --> Factor Va / VIIIa cleavage
14
Factor XIIIa
Stabolizes fibrin meshwork
15
Vitamin K is needed for:
II, VII, IX, X
16
Requires Ca++
V, VIII, VII
17
vWF is from?
Weibel-palade bodies of endothelial cells and alpha granules of platelets
18
Platelet plug formation: 1. injury
endothelial damage --> transient vasoconstriction via neural stimulation reflex and endothelin (released from damaged cell)
19
Platelet plug formation: 2. Exposure
vWF binds collagen
20
Platelet plug formation: 3. Adhesion
Platelets bind vWF via Gp Ib --> conformational change --> dense granule release (ADP/Ca++ --> coagulation), TXA2 --> platelet aggregation
21
Platelet plug formation: 4. Activation
ADP binding receptor --> Gp IIb/IIIa expression
22
Platelet plug formation: 5. Aggregation
Fibrinogen binds Gp IIb/IIIa linking platelets
23
Acanthocyte
Liver disease, abetalipoproteinemia (cholesterol dysregulation): Spiny cell
24
Basophillic stippling
Lead poisoning
25
Degmacyte
Bite cell; G6PD deficiency
26
Target cell
HbC disease, asplenia, Liver disease, thalasemia
27
Heinz bodies
Oxidation of Hb-SH groups to S--S --> Hb precipitation --> phavocytic damage to RBC membrane --> bite cells. Seen in G6PD deficiency, and alpha thalasemia
28
Howell jolly bodies
Basophillic remnants found in RBCs.
29
Iron absorption state
Fe3+
30
