RSL - Haem - Cancer Flashcards Preview

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Flashcards in RSL - Haem - Cancer Deck (66):
1

Multiple myeloma: symptoms

CRAB: Hyper calcemia, Renal failure, Anemia, Bone pain

2

Myelodysplastic syndromes

Hyperplastic marrow with pancytopenia (megaloblastic hematopoesis). Also no hepatosplenomegaly

3

3 myeloid Neoplasm types

1. Acute myeloid leukemias (stopped at blast)
2. Myeloproliferative disorders (terminal diff.)
3. Myelodysplastic disorders (disorganized Terminal diff)

4

ALL - age

5

ALL - T-cell presentation

Thymic mass in teenager (lymphoma)

6

ALL - T-cell marker

CD2, 3, 4, 5, 6, 7 ,8 (pre-T cell tumor)

7

ALL - General markers

TdT+ (pre-T/B cells), CD10 (pre-B cell only)

8

ALL - Good prognosis translocation

t(12;21)

9

ALL - B-cell presentation

Leukemia (pre-B-cell tumor)

10

ALL - t(12;21)

B-Cell, kids, good prognosis

11

ALL - t(9;22)

B-cell, adults, poor prognosis

12

ALL - Association

Down syndrome

13

ALL - Metastasis

Brain and testes

14

SLL/CLL - age

>60

15

SLL/CLL - Cells/markers?

B-cell, CD20+, CD5+ (aberrantly expressed)

16

SLL/CLL - Histology of peripheral smear?

smudge cells

17

SLL/CLL - Associations

Hemolytic anemia (if B-cells produce Ab)

18

SLL/CLL - SLL vs. CLL

CLL = increased peripheral blood lymphocytosis or bone marrow involvement (>4000cells/µL)

19

SLL/CLL - complications

Transformation to LBCL

20

Hairy cell leukemia - age

adults / elderly

21

Hairy cell leukemia - cells?

mature B-cells

22

Hairy cell leukemia - Histology?

filamentous hair like projections. Stains with TRAP

23

Hairy cell leukemia - complications?

Marrow fibrosis --> dry tap

24

Hairy cell leukemia - extra BM?

splenomegaly, no lymphadenopathy

25

Hairy cell leukemia - treatment

2-CDA (cladribine)

26

AML - age

~65

27

AML - Histology?

Auer rods: MPO + cytoplasmic inclusions seen mostly in M3 AML. Also increased myeloblasts on peripheral smear

28

AML - Risk factors

Alkylating chemotherapy, radiation, myeloproliferative disorders, down syndrome

29

AML - Complications

DIC

30

CML - age

45-85

31

CML - cell?

myeloid stem cell

32

CML - splenomegaly?

yes

33

CML - complications?

transition to AML or ALL (blast crisis)

34

CML - LAP score

low

35

CML - treatment

imatinib

36

Langerhans cell histiocytosis - age

child

37

Langerhans cell histiocytosis - presentation

lytic bone lesions and skin rash or recurren otitis media with a mass involving mastoid

38

Langerhans cell histiocytosis - Cells?

T-cells

39

Langerhans cell histiocytosis - Markers?

S100 (mesodermal origin) and CD1a

40

Langerhans cell histiocytosis - Histology

Birbeck granules

41

Polycythemia vera - mutation

Jak2

42

Polycythemia vera - symptoms

intense itching after shower (basophils)

43

erythromelegia

severe burning pain and red-blue discoloration in Polycythemia vera

44

Polycythemia vera - symptoms:

Blurry vision, headache, splenomegaly, venous thrombosis, flushed face, peptic ulceration

45

Essential thrombocytosis - symptoms

bleeding, thrombosis

46

Essential thrombocytosis - Complications

DOES NOT: cause marrow fibrosis, acute leukemia, or hyperuricemia like others

47

Myelofibrosis - diesease process

increased fibroblasts in response to increased monoclonal cell lines.

48

Myelofibrosis - histology

tear drop cells

49

Myelofibrosis - symptoms

Massive splenomegaly dt/ extramedullary hematopoeisis

50

Polycythemia vera - RBCs, WBCs, Platelets

High, high, high

51

Essential thrombocytosis - RBCs, WBCs, Platelets

normal, normal, normal

52

Myelofibrosis - RBCs, WBCs, Platelets

Low, variable, variable

53

CML - RBCs, WBCs, Platelets

Low, high, high

54

Reed-sternberg cell origin

CD15+, CD30+, B-cell origin

55

Hodgkin lymphoma - Prognostic factors

High % lymphocytes = Better prognosis

56

Burkitts lymphoma - Jaw lesion

Endemic form in africa

57

Burkitts lymphoma - Pelvis / abdomen

Sporatic form

58

Mantle cell lymphoma marker

CD5+

59

Mycosis fungoides

Cutaneous T cell lymphoma (skin patches/plaques)

60

Sezary syndrome

T-cell leukemia

61

Marginal zone lymphoma

Hashimotos, sjogrens, H. pylori (maltoma)

62

t(8;14)

Burkitt lymphoma - c-myc : Ig Heavy chain (transcription factor)

63

t(9;22)

CML, AML - BCR : ABL (tyrosine kinase)

64

t(11;14)

Mantle cell lymphoma - Cyclin D : IgH

65

t(14;18)

Follicular lymphoma - IgH : Bcl-2 (anti-apoptotic molecule)

66

t(15;17)

AML (M3) - PML/RARalpha : All-trans-retinoid acid (inhibition of myeloblasts)