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Flashcards in RSL - Haem - Cancer Deck (66)
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1

Multiple myeloma: symptoms

CRAB: Hyper calcemia, Renal failure, Anemia, Bone pain

2

Myelodysplastic syndromes

Hyperplastic marrow with pancytopenia (megaloblastic hematopoesis). Also no hepatosplenomegaly

3

3 myeloid Neoplasm types

1. Acute myeloid leukemias (stopped at blast)
2. Myeloproliferative disorders (terminal diff.)
3. Myelodysplastic disorders (disorganized Terminal diff)

4

ALL - age

5

ALL - T-cell presentation

Thymic mass in teenager (lymphoma)

6

ALL - T-cell marker

CD2, 3, 4, 5, 6, 7 ,8 (pre-T cell tumor)

7

ALL - General markers

TdT+ (pre-T/B cells), CD10 (pre-B cell only)

8

ALL - Good prognosis translocation

t(12;21)

9

ALL - B-cell presentation

Leukemia (pre-B-cell tumor)

10

ALL - t(12;21)

B-Cell, kids, good prognosis

11

ALL - t(9;22)

B-cell, adults, poor prognosis

12

ALL - Association

Down syndrome

13

ALL - Metastasis

Brain and testes

14

SLL/CLL - age

>60

15

SLL/CLL - Cells/markers?

B-cell, CD20+, CD5+ (aberrantly expressed)

16

SLL/CLL - Histology of peripheral smear?

smudge cells

17

SLL/CLL - Associations

Hemolytic anemia (if B-cells produce Ab)

18

SLL/CLL - SLL vs. CLL

CLL = increased peripheral blood lymphocytosis or bone marrow involvement (>4000cells/µL)

19

SLL/CLL - complications

Transformation to LBCL

20

Hairy cell leukemia - age

adults / elderly

21

Hairy cell leukemia - cells?

mature B-cells

22

Hairy cell leukemia - Histology?

filamentous hair like projections. Stains with TRAP

23

Hairy cell leukemia - complications?

Marrow fibrosis --> dry tap

24

Hairy cell leukemia - extra BM?

splenomegaly, no lymphadenopathy

25

Hairy cell leukemia - treatment

2-CDA (cladribine)

26

AML - age

~65

27

AML - Histology?

Auer rods: MPO + cytoplasmic inclusions seen mostly in M3 AML. Also increased myeloblasts on peripheral smear

28

AML - Risk factors

Alkylating chemotherapy, radiation, myeloproliferative disorders, down syndrome

29

AML - Complications

DIC

30

CML - age

45-85