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Ryan's shit list - Step 1 > RSL - Haem - Cancer > Flashcards

RSL - Haem - Cancer Flashcards

(66 cards)

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1
Q

Multiple myeloma: symptoms

A

CRAB: Hyper calcemia, Renal failure, Anemia, Bone pain

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2
Q

Myelodysplastic syndromes

A

Hyperplastic marrow with pancytopenia (megaloblastic hematopoesis). Also no hepatosplenomegaly

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3
Q

3 myeloid Neoplasm types

A
  1. Acute myeloid leukemias (stopped at blast)
  2. Myeloproliferative disorders (terminal diff.)
  3. Myelodysplastic disorders (disorganized Terminal diff)
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4
Q

ALL - age

A
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5
Q

ALL - T-cell presentation

A

Thymic mass in teenager (lymphoma)

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6
Q

ALL - T-cell marker

A

CD2, 3, 4, 5, 6, 7 ,8 (pre-T cell tumor)

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7
Q

ALL - General markers

A

TdT+ (pre-T/B cells), CD10 (pre-B cell only)

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8
Q

ALL - Good prognosis translocation

A

t(12;21)

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9
Q

ALL - B-cell presentation

A

Leukemia (pre-B-cell tumor)

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10
Q

ALL - t(12;21)

A

B-Cell, kids, good prognosis

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11
Q

ALL - t(9;22)

A

B-cell, adults, poor prognosis

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12
Q

ALL - Association

A

Down syndrome

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13
Q

ALL - Metastasis

A

Brain and testes

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14
Q

SLL/CLL - age

A

> 60

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15
Q

SLL/CLL - Cells/markers?

A

B-cell, CD20+, CD5+ (aberrantly expressed)

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16
Q

SLL/CLL - Histology of peripheral smear?

A

smudge cells

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17
Q

SLL/CLL - Associations

A

Hemolytic anemia (if B-cells produce Ab)

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18
Q

SLL/CLL - SLL vs. CLL

A

CLL = increased peripheral blood lymphocytosis or bone marrow involvement (>4000cells/µL)

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19
Q

SLL/CLL - complications

A

Transformation to LBCL

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20
Q

Hairy cell leukemia - age

A

adults / elderly

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21
Q

Hairy cell leukemia - cells?

A

mature B-cells

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22
Q

Hairy cell leukemia - Histology?

A

filamentous hair like projections. Stains with TRAP

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23
Q

Hairy cell leukemia - complications?

A

Marrow fibrosis –> dry tap

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24
Q

Hairy cell leukemia - extra BM?

A

splenomegaly, no lymphadenopathy

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25
Hairy cell leukemia - treatment
2-CDA (cladribine)
26
AML - age
~65
27
AML - Histology?
Auer rods: MPO + cytoplasmic inclusions seen mostly in M3 AML. Also increased myeloblasts on peripheral smear
28
AML - Risk factors
Alkylating chemotherapy, radiation, myeloproliferative disorders, down syndrome
29
AML - Complications
DIC
30
CML - age
45-85
31
CML - cell?
myeloid stem cell
32
CML - splenomegaly?
yes
33
CML - complications?
transition to AML or ALL (blast crisis)
34
CML - LAP score
low
35
CML - treatment
imatinib
36
Langerhans cell histiocytosis - age
child
37
Langerhans cell histiocytosis - presentation
lytic bone lesions and skin rash or recurren otitis media with a mass involving mastoid
38
Langerhans cell histiocytosis - Cells?
T-cells
39
Langerhans cell histiocytosis - Markers?
S100 (mesodermal origin) and CD1a
40
Langerhans cell histiocytosis - Histology
Birbeck granules
41
Polycythemia vera - mutation
Jak2
42
Polycythemia vera - symptoms
intense itching after shower (basophils)
43
erythromelegia
severe burning pain and red-blue discoloration in Polycythemia vera
44
Polycythemia vera - symptoms:
Blurry vision, headache, splenomegaly, venous thrombosis, flushed face, peptic ulceration
45
Essential thrombocytosis - symptoms
bleeding, thrombosis
46
Essential thrombocytosis - Complications
DOES NOT: cause marrow fibrosis, acute leukemia, or hyperuricemia like others
47
Myelofibrosis - diesease process
increased fibroblasts in response to increased monoclonal cell lines.
48
Myelofibrosis - histology
tear drop cells
49
Myelofibrosis - symptoms
Massive splenomegaly dt/ extramedullary hematopoeisis
50
Polycythemia vera - RBCs, WBCs, Platelets
High, high, high
51
Essential thrombocytosis - RBCs, WBCs, Platelets
normal, normal, normal
52
Myelofibrosis - RBCs, WBCs, Platelets
Low, variable, variable
53
CML - RBCs, WBCs, Platelets
Low, high, high
54
Reed-sternberg cell origin
CD15+, CD30+, B-cell origin
55
Hodgkin lymphoma - Prognostic factors
High % lymphocytes = Better prognosis
56
Burkitts lymphoma - Jaw lesion
Endemic form in africa
57
Burkitts lymphoma - Pelvis / abdomen
Sporatic form
58
Mantle cell lymphoma marker
CD5+
59
Mycosis fungoides
Cutaneous T cell lymphoma (skin patches/plaques)
60
Sezary syndrome
T-cell leukemia
61
Marginal zone lymphoma
Hashimotos, sjogrens, H. pylori (maltoma)
62
t(8;14)
Burkitt lymphoma - c-myc : Ig Heavy chain (transcription factor)
63
t(9;22)
CML, AML - BCR : ABL (tyrosine kinase)
64
t(11;14)
Mantle cell lymphoma - Cyclin D : IgH
65
t(14;18)
Follicular lymphoma - IgH : Bcl-2 (anti-apoptotic molecule)
66
t(15;17)
AML (M3) - PML/RARalpha : All-trans-retinoid acid (inhibition of myeloblasts)

Ryan's shit list - Step 1 (27 decks)

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