Flashcards in RSL - Haem - Cancer Deck (66)
Multiple myeloma: symptoms
CRAB: Hyper calcemia, Renal failure, Anemia, Bone pain
Hyperplastic marrow with pancytopenia (megaloblastic hematopoesis). Also no hepatosplenomegaly
3 myeloid Neoplasm types
1. Acute myeloid leukemias (stopped at blast)
2. Myeloproliferative disorders (terminal diff.)
3. Myelodysplastic disorders (disorganized Terminal diff)
ALL - age
ALL - T-cell presentation
Thymic mass in teenager (lymphoma)
ALL - T-cell marker
CD2, 3, 4, 5, 6, 7 ,8 (pre-T cell tumor)
ALL - General markers
TdT+ (pre-T/B cells), CD10 (pre-B cell only)
ALL - Good prognosis translocation
ALL - B-cell presentation
Leukemia (pre-B-cell tumor)
ALL - t(12;21)
B-Cell, kids, good prognosis
ALL - t(9;22)
B-cell, adults, poor prognosis
ALL - Association
ALL - Metastasis
Brain and testes
SLL/CLL - age
SLL/CLL - Cells/markers?
B-cell, CD20+, CD5+ (aberrantly expressed)
SLL/CLL - Histology of peripheral smear?
SLL/CLL - Associations
Hemolytic anemia (if B-cells produce Ab)
SLL/CLL - SLL vs. CLL
CLL = increased peripheral blood lymphocytosis or bone marrow involvement (>4000cells/µL)
SLL/CLL - complications
Transformation to LBCL
Hairy cell leukemia - age
adults / elderly
Hairy cell leukemia - cells?
Hairy cell leukemia - Histology?
filamentous hair like projections. Stains with TRAP
Hairy cell leukemia - complications?
Marrow fibrosis --> dry tap
Hairy cell leukemia - extra BM?
splenomegaly, no lymphadenopathy
Hairy cell leukemia - treatment
AML - age
AML - Histology?
Auer rods: MPO + cytoplasmic inclusions seen mostly in M3 AML. Also increased myeloblasts on peripheral smear
AML - Risk factors
Alkylating chemotherapy, radiation, myeloproliferative disorders, down syndrome
AML - Complications