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Year 2 Semester 2 > Skin > Flashcards

Flashcards in Skin Deck (41)
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31

What is the function of PGI2?

Acts on IP to cause vasodilation and inhibition of platelet aggregation

32

Circulating prostaglandins are rapidly catabolised by enzymes in which organs?

Lung, kidney, spleen, adipose tissue, and intestine

33

Why should care be taken when administering PGF2-alpha?

Readily absorbed through skin so wear gloves
Risk to asthmatics (causes bronchoconstriction) and pregnant women

34

What are 2 adverse effects of PGF2-alpha?

Bronchoconstriction and increased GI motility

35

How do PGE analogues help protect against gastric ulceration?

Directly inhibit gastric acid secretion
Facilitate PGE-mediated mucosal defence

36

What is the difference between constitutive and regulated secretion?

Constitutive= continuous, regardless of environmental factors
Regulated= only secreted in response to a specific signal

37

What is the difference between B1 and B2 bradykinin receptors?

B1=induced in inflammation
B2=constitutive

38

What are the functions of bradykinin?

Increase vascular permeability
Vasodilation
Stimulation of pain nerve endings
Fluid secretion in GI tract and airways
Contraction of intestinal and uterine smooth muscle

39

What are the 4 main classes of cytokines?

Chemokines
Interferons
Interleukins
Colony stimulating factors

40

What is a cytokine?

Soluble protein or polypeptide released from a cell

41

Give and explain some clinical signs associated with a disturbance of skin homeostasis

Pruritis
Scaling due to epidermal hyperplasia (increased keratinocytes)
Greasiness due to increased sebum secretion
Odour due to microbial proliferation (decreased resistance to microbes)