Flashcards in Skin Deck (41)
What is the function of PGI2?
Acts on IP to cause vasodilation and inhibition of platelet aggregation
Circulating prostaglandins are rapidly catabolised by enzymes in which organs?
Lung, kidney, spleen, adipose tissue, and intestine
Why should care be taken when administering PGF2-alpha?
Readily absorbed through skin so wear gloves
Risk to asthmatics (causes bronchoconstriction) and pregnant women
What are 2 adverse effects of PGF2-alpha?
Bronchoconstriction and increased GI motility
How do PGE analogues help protect against gastric ulceration?
Directly inhibit gastric acid secretion
Facilitate PGE-mediated mucosal defence
What is the difference between constitutive and regulated secretion?
Constitutive= continuous, regardless of environmental factors
Regulated= only secreted in response to a specific signal
What is the difference between B1 and B2 bradykinin receptors?
B1=induced in inflammation
What are the functions of bradykinin?
Increase vascular permeability
Stimulation of pain nerve endings
Fluid secretion in GI tract and airways
Contraction of intestinal and uterine smooth muscle
What are the 4 main classes of cytokines?
Colony stimulating factors
What is a cytokine?
Soluble protein or polypeptide released from a cell