Flashcards in Systemic Viral Infection: Mumps, Measles, Rubella and PB19 Deck (20):
Acute viral illness that causes parotitis and can cause orchitis
How is mumps transmitted?
What is the long term outcome of mumps?
Lifelong protective immunity
What are some of the systemic effects of mumps infection?
Can affect the pancreas, testes, ovaries, peripheral nerves, eye, inner ear and CNS.
What is the pathogenesis of mumps?
Infects epithelial cells of the respiratory tract and spreads via viremia leading to a systemic infection
What immunity is required for control of mumps?
Cell-mediated immunity is essential for control of infection and responsible for a portion of the symptoms. Antibody is not sufficient due to mumps’ ability to spread cell to cell.
What is the lab diagnosis for mumps done with?
- Positive serologic test for mumps IgM antibody
- Significant increase in mumps IgG Ab
Mild respiratory infection that spreads to cervical lymph nodes and viremia leads to fever and rash
What is a complication of measles?
Immunosuppression can lead to other infections being superimposed onto the measles infection
Salt like spots seen inside the oral mucosa diagnostic of measles
What patients are at increased risk of subacute sclerosing panencephalitis?
Younger patients. The younger they are, the greater the risk - especially infants
AKA German measles and presents with a upper respiratory tract infection with a maculopapular rash
How is rubella diagnosed in the lab?
What is a high risk population for rubella?
What can occur if a pregnant woman is infected with rubella?
- Congenital Rubella Syndrome
What are these symptoms associated with?
• Heart defects
• Mental retardation
• Bone alterations
• Liver and spleen damage
Congenital Rubella Syndrome
What is "slapped cheek" syndrome a symptom of?
Parvovirus B19 infection
What is the pathogenesis of parvovirus B19 infection?
Infects mitotically active erythroid precursor cells in the bone marrow and establishes lytic infection
What is the risk for parvovirus B19 in pregnant women?
Virus can cross the placenta and infect the fetus leading to severe anemia that can lead to spontaneous abortion