TRH's female repro phys; 3.31 Flashcards Preview

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Flashcards in TRH's female repro phys; 3.31 Deck (50):
1

Where are granulosa cells?

Around follicle...and antrum later on

2

What kind of receptor do granulosa cells have?

FSH receptor

3

What do granulosa cells produce?

Inhibin
Estrogen (estrone and estradiol-17β)

4

What is the downstream effect of inhibin?

Inhibits FSH secretion

5

What enzyme in granulosa cells form estrogen hormones?

CYP19 (aromatase)
Androstenedione → estrone (weak estrogen)
Testosterone → estradiol-17β (potent estrogen)

6

What is the downstream effect of estrogen on the HPO axis?

At low concentrations → suppresses secretion of FSH/LH

At high concentrations → stimulates secretion of FSH/LH

7

Where are theca cells?

Around granulosa cells

8

What kind of receptors do theca cells have?

LH receptors
LDL receptors

9

What do theca cells produce?

Androstenedione and some testosterone (goes to granulosa cells or vasculature)

10

What hypothalamic hormone stimulates secretion of FSH and LH?

Gonadotropin Releasing Hormone (GnRH)

11

What hypothalamic nucleus produces GnRH?

The arcuate nucleus produces GnRH

12

What kind of receptor does GnRH bind to?

Gq

13

hCG is released from where after fertilization of an egg?

Placenta

14

What is the effect of hCG?

hCG "rescues" the corpus luteum → keeps progesterone and estrogen levels high to maintain pregnancy

15

What else does the placenta do during pregnancy?

Takes over steroidogenesis and pregnancy maintenance

16

This is in regards to the menstrual cycle. What is the effect of the corpus luteum dying?

Corpus luteum dying → decreased estrogen and progesterone

17

This is in regards to the menstrual cycle. What is the effect of decreased estrogen and progesterone?

Decreased estrogen and progesterone → increased FSH/LH

(decreased feedback inhibition)

18

This is in regards to the menstrual cycle. What is the effect of increased FSH/LH?

Increased FSH/LH → gradually increased estrogen and growing/maturing follicles

(increases synthesis in granulosa cells)

19

This is in regards to the menstrual cycle. What is the effect of the gradual increase in estrogen?

Gradually increased estrogen → decreased FSH

(feedback inhibition)

20

This is in regards to the menstrual cycle. What is the effect of decreased FSH?

Decreased FSH → selection of largest/most FSH sensitive follicle

21

This is in regards to the menstrual cycle. What is the effect of selecting a single dominant follicle?

Single large follicle → produces HIGH levels of estrogen

22

This is in regards to the menstrual cycle. What is the effect of HIGH levels of estrogen?

HIGH levels of estrogen → stimulate secretion of FSH/LH

(Inhibin is still inhibiting FSH secretion...so only LH is dramatically increased)

23

This is in regards to the menstrual cycle. What is the effect of the LH surge?

LH surge → meiotic maturation, ovulation, and luteinization

24

This is in regards to the menstrual cycle. What is the effect of luteinization?

Luteinization → corpus luteum → HIGH levels of progesterone with some estrogen and inhibin

25

This is in regards to the menstrual cycle. What is the effect of HIGH levels of progesterone with some estrogen and inhibin?

HIGH levels of progesterone with some estrogen and inhibin → decreased FSH/LH

26

This is in regards to the menstrual cycle. What is the effect of decreased LH?

Decreased LH → corpus luteum dies

27

What can "rescue" the corpus luteum? (already on a card...but it fit here too)

hCG causes an increase in LH-like activity

28

What important hormonal shift induces parturition?

P > E → E > P

29

What effect does progesterone have on myometrial cells?

Hyperpolarization of myometrial cells → prevents contractions

30

What effect does progesterone have on adrenergic, oxytocin, and estrogen receptors?

Decreases/inhibits synthesis

31

What effect does progesterone have on prostaglandin?

Promotes storage of prostaglandin synthesizing enzymes

32

What effect does estrogen have on oxytocin receptors?

Estrogen increases oxytocin receptors

33

What effect does estrogen have on the uterus?

Estrogen promotes uterine contractility

34

What does estrogen do to the cervix?

Estrogen ripens the cervix

35

What effect does estrogen have on prostaglandin?

Increases local release → myometrial contractions

36

Which prostaglandins play major roles in reproduction?

PGF(2) and PHE

37

What effect do prostaglandins have on the antral (Graafian) follicle?

Involved in the rupture (release of the oocyte)

38

What role do prostaglandins play in the menstrual cycle?

Myometrial contraction during menstruation

39

What role do prostaglandins play in pregnancy/parturition?

Cause contactions (Braxton Hicks during pregnancy an strong uterine during parturition)

40

What develops during mammogenesis (breast development during puberty)

Epithelial ductal tree

41

What hormones are required for mammogenesis?

Estrogen, glucocorticoids, and GH (somatotropin)

42

When does lactogenesis I occur?

Mid/late pregnancy

43

What happens during lactogenesis I?

Lobular-alveolar growth

44

What hormones induce lactogenesis I?

Estrogen, glucocorticoids, prolactin, progesterone, and hPL

45

When does lactogenesis II occur?

Post-partum

46

What happens during lactogenesis II?

Onset of copious milk secretion

47

What induces lactogenesis II?

Decreased progesterone (parturition of the placenta)

48

What is galactopoiesis?

Maintenance of lactation

Presence of prolactin and removal of milk

49

What induces milk ejection (let-down)?

Oxytocin, anticipation, and suckling

50

What is involution?

Lack of prolactin