Flashcards in Vancomycin Deck (10)
What is vancomycin an inhibitor of?
inhibitor of gram (+) cell wall biosynthesis
involves binding to the peptidyl side chain D-alanyl-D-alanyl terminus in the peptidoglycan precursor (before cross-linking)
Vancomycin is primarily bactericidal and active against what?
gram (+) bacteria
What is not susceptible to vancomycin?
essentially all gram (-) bacilli and mycobacteria
Vancomycin has been considered the last line of defense in which kind of infections?
hospital-acquired multi-drug resistance staphylococcal and streptococcal infections
What kind of patients are susceptible to vancomycin-resistant enterococcal infections?
Mechanism of resistance to vancomycin?
mutation of the peptidoglycan cell wall precursor from D-Ala-D-Ala to D-Ala-D-lactate
Why doesn't vancomycin inhibit the transpeptidase when the substrate is D-Ala-D-lactate?
because vancomycin has 1000 times less affinity for the D-Ala-D-lactate precursor
Possible side effects of vancomycin?
a hypersensitive response that results in a red skin rash and potential anaphylaxis