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Pharmacology Test #2 > Vancomycin > Flashcards

Flashcards in Vancomycin Deck (10)
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1

What is vancomycin an inhibitor of?

inhibitor of gram (+) cell wall biosynthesis

2

Vancomycin mechanism

involves binding to the peptidyl side chain D-alanyl-D-alanyl terminus in the peptidoglycan precursor (before cross-linking)

3

Vancomycin is primarily bactericidal and active against what?

gram (+) bacteria

4

What is not susceptible to vancomycin?

essentially all gram (-) bacilli and mycobacteria

5

Vancomycin has been considered the last line of defense in which kind of infections?

hospital-acquired multi-drug resistance staphylococcal and streptococcal infections

6

What kind of patients are susceptible to vancomycin-resistant enterococcal infections?

immunocompromised patients

7

Mechanism of resistance to vancomycin?

mutation of the peptidoglycan cell wall precursor from D-Ala-D-Ala to D-Ala-D-lactate

8

Why doesn't vancomycin inhibit the transpeptidase when the substrate is D-Ala-D-lactate?

because vancomycin has 1000 times less affinity for the D-Ala-D-lactate precursor

9

Possible side effects of vancomycin?

a hypersensitive response that results in a red skin rash and potential anaphylaxis

10

Most significant toxicity problems with vancomycin?

nephrotoxicity and ototoxicity (rare)