Week 3 Flashcards

(91 cards)

1
Q

Epidemiology definition

A

“Epidemiology is the study of the distribution and determinants of health-related states or events (including disease), and the application of this study to the control of diseases and other health problems”

Old science. -25,000 years old from Greece

Started with understanding correlation with disease

Brosdstream pump – track how disease movement throughout a city – closing pump take away the vectors tht lead to a disease

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2
Q

Key Concepts in Epidemiology

A

Key concepts include:

populations
health phenomena
determinants of health

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3
Q

2 fundamental assumptions - epidemiology

A

Disease does not occur by chance

Distribution of disease is not random

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4
Q

disease does not just occur by chance and distribution of disease

A

Reason why it is happening
Distribution of disease has a pattern to it – not random – there is a pattern

Can track in a city, country or around the globe

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5
Q

epidemiological triangle

A

3 things to consider

Agent – virus or bacteria

Environment where seeing it for first time or where it is inhostpiltiible

Host – how is it getting from point A to point B, how does it live within, how is it transmitted, or is it?

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6
Q

Role of epidemiology in global health

A

Identify key health status indicators

Study and respond to the global burden of disease

Track and use transitions & trends in health to prevent and treat disease

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7
Q

what does global health show

A

how things are linked together

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8
Q

diseases within countries

A

linked back to the social determinants of health and income

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9
Q

Track how disease moves
Imagine: things look different epidemioloigc prior to internet

A

took more effort to find what you need, someone would need to mail information, now we have speed, more data collected, can manipulate data to show relationships, can analyzed larger data sets – allow us to have a better idea of what’s going on globally, better communication – much quicker about what is happening on one side of the world

Greater awareness and greater ability to communicate – helps us ake decision whether we need actions or in actions

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10
Q

key health indicators

A

infant mortality rate

life expectancy at birth

neonatal mortality rate

maternal mortality rate

under 5 mortality rate

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11
Q

key health indicators what they are used for?

A

Used to measure life expectancy

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12
Q

global burden of disease

A

how long someone is going to live

info on overall health and how we contributor to society like working

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13
Q

when looking at data sets and information

A

this is the way that life expectancy is measure and community health in communities

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14
Q

what does the key health indicators - like what are they all based

A

In these 5 focus on women and children (women who dies in pregnancy will not birth any more children), humans that die at birth or before 5 will have an impact on population

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15
Q

what does high child mortality mean

A

High child mortality rate – than life expectancy of that population goes down – people are dying before the age of 5

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16
Q

infant mortality rate

A
  • # deaths /1000 live births < 1 year old
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17
Q

Life expectancy at Birth

A

average age infant could life if mortality trends did not change for infant’s lifetime

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18
Q

Neonatal Mortality Rate

A

deaths /1000 live births < 28 days of age

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19
Q

Maternal Mortality Rate

A

women die in pregnancy & childbirth / 100,000

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20
Q

Under Five Mortality Rate -

A

probability infant die before 5 years of age/1000

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21
Q

incidence

A

Incidence refers to the # of new cases of a disease within a specific time period

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22
Q

prevalence

A

prevalence indicates the total # of existing cases at a given time.

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23
Q

factors influencing prevalence - increased by:

A
  • longer duration of the disease
  • prolongation of life of patients without cure
  • increase in new cases (increase in incidence)
    -in-migration of cases
  • out-migration of healthy people
  • in-migration of susceptible people
    -improved diagnostic facilities (better reporting)
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24
Q

factors influencing prevalence - decreased by:

A
  • shorter duration of the disease
  • high case - fatality rate from disease
  • decrease in new cases (decrease in incidence)
  • in-migration of healthy people
  • out- migration of cases
  • improved cure rate of cases
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25
basic term of incidence
how many new cases are appearing of new cases each day covid-19 stats of COVID every single day
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basic terms of prevalence
time of existing cases e.g., cancer and HIV increasing
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two diseases that have increasing prevalence and why
cancer HIV - people were not living long live new treatment option and medications treating newborns born to moms who are HIV positive - with innovations in health seeing increased life expectancy in populations that did not have that expectancy a few decades ago can live for decades with HIV
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what can impact prevalence
healthy population of people that migrate out of that area - it will go up - because moving healthy people out - so prevalence increase - need to know what is actually happening to see those changes
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epidemic
incidence rate exceeds what is "expected," based on recent experience - condensed in an area e.g., in south america or brazil
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pandemic
disease that spreads through human populations across a large region all over the world
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endemic
disease or condition regularly found among particular people or in a certain area Endemic – condensed in population but more than one population around the globe e.g., diabetes (increased by 68% in past few years), malaria, chickenpox, dengue fever
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what is happening to mosquitis
Currently as globe heating up – mosquito that carries it has been found in southern Europe, as climate and environment changes, the movement of disease changes Never had to worry in Europe before, because now seeing cases in Europe, opens up the path for malaria to move to other areas that were not there before Disease can move among the three now
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Importance of Epidemiological Research
1. Disease Prevention 2. Impact on Public Health Policy 3. Disease Control Measures 4. Effective Resource Allocation
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examples of disease control measures
Do we need certain vaccinations, restrictions – what needs to happen to keep people safe and minimize movement to disease and viruses around the globe Research helps inform public health policies, decisions about where money goes What to we do with limited resources we have Mpox moving through Africa Need to be able track where the highest number of cases and where it moving to try and put a boundary to stop it
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global burden of disease - considers
considers distribution and impact of diseases worldwide includes both communicable and non-communicable diseases (NCDs) emphasis on need for targeted health interventions and policies to alleviate disease prevalence
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global burden of disease - variations are caused by:
age, sex, income, and all those pieces we need to take into consideration
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examples of how global burden of disease changes overtime - does not stay the same
e.g., diabetes has increased by 64% around the globe
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demographic transition
Left graph Show you how demographic population is shifting In 1900-1995 – how population is getting older People living longer greater advancement in healthcare, changes in sanitation, and environment, and social determrian s of health Right In 2020 How our population is Seeing older population
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what else contributes to increase in the population
decrease infant mortality
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child mortality rate major causes of child death
Malaria Pneumonia Diarrhea Meningitis Measles HIV tetanus
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2100 expected birth rate and effect on population and child birth rates
2100 – our birth rate will not match our death rate Population will not be replaced, that it currently is Greater population of older people then younger people for the first time ever Child mortality rate dropping = more older Communicable disease kill children and child mortality rate decrease – aka these diseases are decreasing Why we are seeing a decline in child mortality even though these disease still exist – more kids getting vaccinated, better treatment (can treat diseases) Not happening as often and when they do we can treat Prevention is key and the cheapest thing we can do in public health – vacinations cheap cheap cheap Still see them in low income country – because low income country still the main reasons why children are dying Overall burden of disease – that burden will ldecrase, as infectious disease decreases and will not be main causes
42
fertility rates
Total fertility rate, 1950–2100, by GBD super-region and for the globe number of children born/women
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decline in mortality or deaths rate
followed by decline in birth rates Varies from community to community As women get older – menopause Women can bare children through certain age then cannot, as population age and birth rate not replacing – then see lower birth rates- due to not being a possibility Burden of disease
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burden of disease shifting from communicable disease -> NCD top NCDs
Top NCDs: cardiovascular disease Diabetes Mental health challenges Cancer Low back pain
45
why are we shifting from communicable to non-communicable
As mortality rates goes up see an epidemiological transition Non-communicable diseases are more common and number 1 – can live longer Pandemic changes numbers Low back pain Risk factors for CVD and diabetes Intertwined – lifestyle, stress Non-communicable diseases killed 43 million people – 73% IN LOW INCOME COUNTRIES MENTAL HEALTH CHALLENGES - top depression and anxiety – linked to substance use and suicide Disproportionately low and middle income countries are affected – due to social detemriants of health
46
importance of video of follow up to another video by another epidemiologist in 2010
That epidemiologist. – prediction was that the world was getting better and better, more economic security all around Showing you trends that are happening and how information can be missed used for people to get a certain message a crossed and data can be manipulated a certain way and the message is not the full picture Ignoring some facts and sharing others National averages misleading Higher income countries struggle with mental problems Ultimately – always be aware of what you are reading, where it is coming from, who published it, what the overall goal is, know some history and context We can take numbers and communicate them in any way we want to Even when we look at the top non-communicable diseases globally – depends on who shows them This video was 2016 – older – know the statistics have changes, especially with mental health e.g., pandemic
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Why NCDs overtaking infectious diseases?
Aging population urbanization Diet Reduced Physical activity Improved water & sanitation Increased use of Tobacco, alcohol
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how modernization has influenced why NCD is overcoming CD
#1 reason seeing this is aging populations
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Pros and cons from urbanization and globalization
cons e.g., diabetes and CVD. And urbanization – the risk factors are diet and physical activity – when someone moves to urban centre –life becomes more sedentary then someone in rural setting like farmer, also more fast food in urban – increase caloric intake and decrease physical activity – changes in body masse Positives – improved water and sanitation – decease in CD, With urbanization in crease alcohol and tobacco – see correlation with anxiety and depression
50
double burden of disease
Coexistence of infectious and non-communicable diseases exist within the same well-focused geographical area, or even within the same family.
51
what is the double burden of disease and an example
Chronic disease and infectious disease –within same geographical area or within a family Mom who during her pregnancy develops diabetes – so with gestational diabetes – blood sugar changes and body masses goes up, baby is born sick, born premature and under birth weight or opposite One day 3 women with gestational diabetes who need a c-section because baby was huge – 9, 11, 14 – so sick Developed in an environment become resistant to sugar Populations where there is malnutrition and micronutrient malnutrition – babies adapt to that change If women moves to urban setting, no longer able to adapt to the diet of from rural to urban setting – causes chronic disease increase Low-income countries – big difference between rural and urban for disease distribution
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comparison between housing situations - image of slums vs white apartments
Different in housing situation Community on left – housing is very different, can assume that it is lower income community vs the tall building on the right hand side and their income is probably different Meters separating the two economic populations Wealthier part are at risk for NCD – because buy the foods and risk factors that leads to those disease, higher caloric intakes, lower activity levels (less activity levels at works) Who is more fortunate in terms of health? Wealthier you are – may live longer but does not necessarily mean healthier – more likely to have NCD When you live in low income country – some have no clean water or sanitation, or some may have depends on where – when you think about the population lower ecnomic – there is a general thought – why would they not want to have more money, in big house – because life is better – but not always better –now at risk for different type of disease- may live logner but quality of life may not necessarily will improve- look at all aspects of those peoples lives More is not always better Clean water and SDH – human rights are the basis Populations impacted differently based on income, diet, environement and how risk factors change when you switch
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Not always straightforward - risk of globalization
Globalization can bring many benefits, and can increase risk of living longer but with NCDs
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how to think about globalization
Think about globalization in terms of geography, in terms of environment and people being impacted and how that will change their lives overall
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Measuring global burden of disease
DALYS and HALES
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DALYS
Disability adjusted life years (dalys)
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DALYS measures:
Measure that quantifies the total health loss due to diseases on a local and a global scale, DALY allow us to measure and compare disease burdens disease burden related to a specific risk-factor accumulated impact of several diseases
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what does an increase in DALYS signify
An increase in DALY signifies overburdened health systems and escalating health challenges
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what does DALYS help guide
Disease leads to suffering for people, for families, for communities, puts pressure on health care, public policy, where government puts funding and where health care agency and global agency targets their funding e.g., UN, WHO Need to be able to communicate what that burden is to inform decision make E.g., accumulated disease burden – accumulate overtime e.g., tobacco use 1-2 not a big change, smoking for 20-30 years COP, lung disease, CVD, accumulated risk Soembody that is 60 years old and smoked for 40 years will not have the same health as someone who never smoked
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DALYS measures health gap in the sum of: DALYS are also defined as
Health gap measure between expected life versus living life with disease The sum of years lost due to premature death (YLLs) & years lived with disability (YLDs) DALYs are also defined as years of healthy life lost
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depression DALYS score
0.7/1 Has quite an impact on a persons life, economics, family – make it that much more challenging to function in life
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baby toes amputaiton DALYS
0.02
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simple terms of DALYS
years of healthy life loss due to disease, illness, injury DALYS = years lived with disability, illness or injury + years of life lost
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DALY classification system
Group 1: Communicable diseases – 35% Group 2: NCDs – 54% Group 3: injuries – 11% 2.5 billion dalys lost yearly due to combination of all three groups The gap between perfect health and having the disease Classification 0-1 and then 3 groups Impact overall population
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examples of a DALY a 5 year old child died, we would need to know that the longest  life expectancy worldwide of a child, being 5 years old, which is 86.4 years. 
If 5 year old child died Lost 81.4 years of life To calculate: Need to know incidence of disease, duration (how long are they expected to live – preveleance) and severity That means that 81.4 years of lives are lost. 
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60 year old woman would die and the longest life expectancy worldwide of a person being 60 years old is 87.8 years 
then the death of a 60-year-old would result in a loss of 27.8 years of life. 
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HALE
HALEs Health Adjusted Life Expectancy # years in good health. The higher number, the better!
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summary of DALYS
DALYs Disability Adjusted Life Expected Summary of years lost due to premature death plus number of years living with disability. The higher this number, definitely not the better
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COMPARING HALE vs DALYS
When you compare – HALE is the health adjusted life expectancy – how many years are expected to be in good health – want the high number, healthy DALY is the gap – not a good thing to be high, disability or disease
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Main drivers of population increase
Living more in urban areas Living longer – aging population, increased lifespan
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demographic changes - urban nd rural
As one goes down one goes up – people need to go somewhere urban regions increasing in population size and rural areas decreasing (more increase in less developed urban areas)
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summary of edpimiology
"Epidemiology studies distribution and determinants of health-related states or events to the control diseases and other health problems Addressing epidemiological transitions, GBD, NCDs, and improving the SDOH are necessary for sustainable improvements in global health Progress and change is Not that straightforward – many turns, u turns and factors that impact the journey
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top 10 risk factors for disease burden children vs older adults
children 1. low birthweight 2. short gestation 3. child underweight 4. household air pollution from solid fuels 5. child wasting 6. child stunting 7. unsafe water source 8. ambient particulae matter pollution 9. unsafe sanitation and handwashing 10. no access to handwashing facility people aged 70+ 1. high blood pressure 2. high fasting plasma glucose (high blood sugar) 3. smoking 4. ambient particulate matter pollution 5. high body mass index 6. kidney dysfunction 7. high LDL cholesterol 8. household air pollution from solid fuels 9. diet high in sodium 10. lead exposure in bone
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looking into the future - NCDs are coming on strong how do we respond?
Promotion and prevention because NCDs coming on strong If we do think of prevention vs treatment Need to happen now We just keep moving goal post – but by doing that never actually doing it Need action now to see change in 25 years Modifiying those risk factors is important
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what drives the change in disease burdens?
Drivers of change Overall life expectancy is increasing – by 4.6 years Why are we seeing increased in life expectancy by 2050. – less infectious diseases, more advanced in healthcare Can make it longer even – because a lot of risk factors are behavioural Health promotion is key Canada does not have a health promotion healthcare system – just try to fic – cost more money and not as effective
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outlook to 2025...
leading causes of disease burden worldwide in 2022 versus 2050 - ischemic heart disease stays number one Heart disease is staying at the top Can we make a difference to attend to it? Absolutely – because diet, tobacco use, sedentary life style are modifiable things, can change what I , how much I move – all choices I Make In those choices I am changing risk factors for disease Individuals also have a responsible globally to take care of themselves so the overall burden of disease is not felt Drop in neonatal disroders Drop in resp disorders Low back pian – sitting all the time, inflammation from sugar, all these things Right Vaccine See those disease become less prevalent If we change behavoiour – we have th ability to change what is forcasted to hapeen in the enxt 25 years
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4th major cause of DALYS
major depressive disorders come 4th as most important cause of DALYs lost
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top 3 NCD
ischemic heart disease respiratory distress CVD
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Diet + increased tobacco + increase alcohol
= Increase incidence of NCDs. Changing patterns in graph of tobacco consumptions – more in medium or low income countries - increase NCD incidence high income staying relatively steady Strain healthcare systems
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Nutritional transition
Increase caloric intake Increase fat Shift from complex to simple carbs Increase salt Decrease dietary fiber & micronutrients Last transition is nutritional transition One of the main drivers in our health Need to be healthy to stay healthy
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health reforms
Access & affordability – can go either way Success or failure depending on what it is and how it unfolds Some good positives In terms of HIV care and treatment Mosquito necks – insecticide embedded – to prevent spread of malaria Ultimately success or failure depends on what is occurring what the response is and if there is actyally a repsonse
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war and conflict
Do not always affect our living conditions, but affect somebodies Displaced people – possessions, clothing, housing, no longer in communities – where wlil they go, not working, rely on somebody else for water, food and safety Collapse of healthcare systems Mental health – PTS, depression, anxiety, fear So many layers to it
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Climate and natural disasters
Fires in California Affects health of population Challenged by sanitation, housing, will not hold up Spread on infectious diseases Fires main concerns – smoke, air pollution – impact people who are living with chronic disease and potential y cause other issues to happen Loss of agriculture, land, loss of forests, loss of income, house Economy – people need to work, but people at work worry about family 1000s of people will loose their jobs if Disney land burns down Certain events impact people
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Economic growth
Reforms Increased global trade Decreased exposure to infections Increase quality of housing Higher traffic accidents Changes in access and affordability - Improvements in health technology
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economic growths are directly tied to
social determants of health
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urbanization
MAJOR INFLUENCE on people’s lives much more pronounced  in less developed area like sub-Saharan Africa, and certain areas of Asia. More people in small geographical area Major influence in terms of living conditions Shift in physical activity, movement, intake – diet, more calories, increase alcohol, tobacco with urbinzation These increase NCD Increase taboccaco = CVD, COPD e.g., NCD ting at :4:22 and follow transcript4:22So all these changes related to urban and  modern living conditions will increase the risk of NCDs.
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what major changes in living conditions with the shift to urbanization do we anticpate?
- changes in diet and physical activity.  In some places intake of alcohol and  tobacco will also increase during urbanization. Play video starting at :3:55 and follow transcript3:55We'll come back to diet in a moment, but in relation to physical activity  a better infrastructure, commuting by road to and from work,  and then generally having a more sedentary lifestyle, and work life, Play video starting at :4:10 and follow transcript4:10in the towns and cities, will often result in a much lower level of physical activity  as compared to the traditional rural life, maybe as a hard-working farmer. Play video starting at :4:22 and follow transcript4:22So all these changes related to urban and  modern living conditions will increase the risk of NCDs.
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demographic changes
55% in 2022 – now in 2050 75% in urban areas Less population in rural areas Farming? Food source? Kelowna is the fastest growing metropolitan area in Canada (multiple cities in Kelowna) Historically 30 years ago – no building in the city higher than 3 stories Seeing declining birth rates overall, will see some areas where populations are increasing Most dramatic is urban areas in low income regions
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Major determinants of change
Demographic changes Urbanization Economic growth Climate changing War & conflicts Improvements in health care measures and systems Changes in agriculture and natural resources management
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Demographic- rural to urban Economic growth – has positives but not all positive Health systems Agriculture and resources managmement Important thing to consider is that all of theses are linked together none operate in isolation
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