1 Antihistamine Flashcards Preview

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Flashcards in 1 Antihistamine Deck (12):
1

histamines

- organic nitrogenous compound involved in inflammatory response
- stored in mast cells and basophils

2

histamine functions

- increases capillary permeability
- neurotransmitter in CNS
- concentrated in skin, lungs, GI tract

3

GI-tract specific histamine effects

- smooth muscle constriction
- increased gastric acid secretion
- nausea, vomiting

4

H1 antagonists... what do they do!??!

they PROTECT at receptor site
they do NOT prevent release of histamines

5

antihistamine indications

- allergic rhinitis/conjunctivitis
- urticaria
- allergic reactions
- motion sickness
- insomnia

6

antihistamine contraindications

children < 2 years of age

7

antihistamine side effects

- anticholinergic effects
- sedative effects
- CNS effects (falls! driving!)

8

cholinergic receptors stimulate...

(acetylcholine receptors)
parasympathetic nervous system

9

Benadryl

Diphenhydramine, H1 antagonist

10

Benadryl contraindications

< 2 yo due to decreased BBB development

11

Benadryl side effects

Decreased SLUD aka anticholinergic effects
Sedation
CNS effects

12

Benadryl inappropriate use

Asthma attack
Third trimester
BPH (due to urinary retention)
REMEMBER SEDATION EFFECTS

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