1 Opioid Analgesics Flashcards Preview

Undeleted > 1 Opioid Analgesics > Flashcards

Flashcards in 1 Opioid Analgesics Deck (25):
1

equianalgesic

dose of opioid agonist that will produce the same degree of analgesia as 10mg of IM morphine

2

opioid

any drug with actions similar to morphine

3

opiate

compound present in opium

4

DEA Schedule I-V aka...

Controlled Substance Schedule (CSS) aka...

5

therapeutic use of agonist opioids

relief of moderate to severe pain

6

longterm opioid use can result in...

...tolerance for decreased RR

7

respiratory depression

most lethal of side effects!!!

RR < 12
can persist for several hours
can contribute to increased intracranial pressure

8

high risk for respiratory depression

respiratory illness, med interactions

9

nursing response to constipation

increase fluids and give meds

10

adverse effects of opioids

- respiratory depression
- constipation
- sedation
- orthostatic hypertension
- emesis
- urinary retention
- biliary colic
- miosis (pupil constriction)
- euphoria/dysphoria
- cough suppression

THESE ARE NOT ALLERGIC REACTIONS

11

abstinence syndrome

withdrawal

12

abstinence syndrome S&S

initial: yawning, sweating, rhinorrhea

middle: irritability, tremor, anorexia, goosebumps

late: sneezing, weakness, N/V, diarrhea, abdominal and muscle cramping, pain

13

toxicity

overdose

14

toxicity S&S

- profound coma
- profound respiratory depression
- pinpoint pupils

death r/t respiratory arrest

15

opioid agonist interactions

- CNS depressants (AKA ALCOHOL!!!)
- anticholinergics
- hypotensive agents
- agonist-antagonist opioids
- monoamine oxidase inhibitor, MAOI (depression treatment)

16

predisposing conditions for opioid agonist interactions that increase riskiness of use

respiratory disease
liver disease
labor/delivery/pregnancy
prostatic hypertrophy
hypotension
head trauma

17

CR

controlled release

18

morphine general safe dosages

ORAL: 10-30mg Q4h (up to 75mg)

IM: 5-15 mg Q4h

IV: 2-10 mg Q1-2h

Equianalgesic --> 30mg PO = 10mg IM

19

CNS opioid receptors x3

Mu (primary)
Kappa (weak)
Delta (no analgesic effects from mess)

20

What effects opioid metabolism?

Organ dysfunction
Other meds
Administration route

21

What does NOT effect opioid metabolism?

Pain source & location

22

Pure opioid agonist (strong)

Morphine

23

Pure opioid agonist (moderate-strong)

Codeine

24

Agonist-antagonist opioid

Nalbupine (Nubain)

25

Pure opioid antagonist

Naloxone (Narcan)

Decks in Undeleted Class (79):