1 Glucocorticoids Flashcards Preview

Undeleted > 1 Glucocorticoids > Flashcards

Flashcards in 1 Glucocorticoids Deck (11):
1

structure

identical to steroids produced by adrenal cortext

2

function

within cytoplasm rather than cell surface

3

indications

endocrine (not our focus)
- adrenal insufficiency
- physiologic doses

NON-ENDOCRINE
- inflammatory processes
- pharmacologic doses

4

glucocorticoids (names)

- Cortisone
- Solu-cortef (hydrocortisone)
- Depo-medrol (methylprednisolone)
- Prednisone
- Orapred (prednisolone)
- Triamcinolone
- Dexamethasone

5

Cortrosyn Stimulation test

Measures ability of adrenal cortext to produce
- adrenocorticotropic hormone (ACTH) administered
- degree of adrenal gland stimulation is measured

6

Prednisone + MOA

Glucocorticoid
Binds to/activates receptors in cytoplasm and nucleus
Suppression of leukocyte migration, decreased capillary permeability

7

Prednisone adverse effects

Osteoporosis
Adrenal insufficiency
Immunosuppression
Psych stuff
PPP (polydipsia, polyuria, polyphagia)

8

Prednisone considerations

DO NOT DISCONTINUE ABRUPTLY
AM dosing more physiologic (faster metab)

9

Growth and development effects

Inhibits cell division
Delays healing
Retards growth of children

10

Calcium metabolism effects

Increases bone resorption
Increases renal clearance
Suppresses bone formation
Decreased intestinal absorption of Ca and Vitamin D

11

Respiratory effects

Not bronchodilator
Inhaled = long term control, not immediate effect (>6 hours)

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