Lewis, P and MNS bgs Flashcards
it is a type 1 glycosphingolipids that are passively absorbed on the RBC membrane plasma
a. ABO
b. Rh
c. Lewis
d. P
Unique because Lewis antigens are not intrinsic to RBCs but are type 1 glycosphingolipids that are passively absorbed on the RBC membrane plasma
Lewis gene is code for the production of ______
a. L-fucose
b. fucosyltransferase
c. glycospingolipids
d. n-acetyl-d galactosine
Lewis gene (Le, FUT3) codes for the production of FUCOSYLTRANSFERASE enzyme
which of the following lewis phenotypes is non secretor
a. Le (a-b-)
b. Le (a+b-)
c. Le (a+b+)
d. Le(a-b+)
Le (a+b-)
- ABH non secretor
Le (a-b+)
- ABH secretor
which of the following phenotype is most frequent in asians
a. Le (a-b-)
b. Le (a+b-)
c. Le (a+b+)
d. Le(a-b+)
The Le(a–b–) phenotype - is found more frequently among AFRICANS
The Le(a+b+) phenotype - is rare among whites and Africans but is more frequent among ASIANS
lewis antibodies is neutralized by
a. enzymes
b. plasma
c. acetic acid
Lewis Antibodies
- Easily neutralized by plasma
this BGS is synthesized by sequential action of glycosyltransferases
a. ABO
b. RH
c. P
d. AO`
The P blood group antigens, like the ABH antigens, are synthesized by sequential action of glycosyltransferases, which add sugars to precursor substances
which of the following phenotype is a marker of apoptosis
a. P1 antigen
b. Anti - P
c. anti - p1
d. Pk
Pk ✓ The Pk antigen is a MARKER OF APOPSOSIS in - GERMINAL CENTER B CELLS - BURKITTS LYMPHOMA -LYMPHOBLASTICL EUKEMIA
which of the following phenotype is found in IgG autoantibody in patient with PCH
a. P1 antigen
b. Anti - P
c. anti - p1
d. Pk
anti - P
- naturally occurring individuals
- Auto Anti-P specificity is found as an IgG autoantibody in patient with Paroxysmal cold hemoglobinuria
which of the following phenotype observed in individuals infected with Echinococcus granulosus
a. P1 antigen
b. Anti - P
c. anti - p1
d. Pk
Anti - P1
- IgM antibody
- Strong anti-P1 was observed in individuals infected with Echinoccocus granulosus
- Strong antibodies to P1 have also been found in patients with FASCIOLIASIS (bovine liver fluke disease) and in bird handlers
which of the following phenotype reacts over a wide thermal range
a. P1 antigen
b. Anti - P
c. anti - p1
d. Anti PP1Pk
Anti- PP1Pk
- originally called Anti - Tja
- Produced by p individuals early in life without RBC sensitization
✓ Reacts over a wide thermal range (both IgM and IgG)
✓ Associated with SPONTANEOUS ABORTION in early pregnancy
✓ Has potential to cause SEVERE HTRs and HDFN.
which of the following phenotype is associatediwth billiar cirrhosis
a. P1 antigen
b. Anti - Pk
c. anti - p1
d. Anti PP1Pk
anti Pk
- associated with BILLIARY CIRRHOSIS
AND AUTOIMMUNE HEMOLYTIC ANEMIA
seen in renal patient, who are dialyzed on equipment sterilized with formaldehyde
a. MN antigen
b. S and s antigen
c. Anti - N
d. Anti-Nf
Anti-Nf - seen in renal patient, who are dialyzed on equipment sterilized with formaldehyde
which of the following MNS bgs reacts with red cell exposed to glucose solution
a. MN antigen
b. Anti - M
c. Anti - N
d. Anti-Nf
Anti - M
✓ May be IgG and IgM
✓ Most examples are cold reactive saline agglutinins
✓ Usually do not bind complement
✓ Do not react with enzyme treated cell
✓ pH-dependent, reacting best at pH 6.5
✓ Others react with red cell exposed to glucose solution
✓ Rarely cause HDN
✓ Shows dosage effect
which of the following MNS bgs is implicated with severe HTR, Hemoglobinuria and HDN
a. Anti S and anti -s
b. Anti - M
c. Anti - N
d. Anti-Nf
Anti- S and Anti-s
✓ Most examples are IgG, reactive at 37’C at the antiglobulin test phase
✓ Implicated with severe hemolytic transfusion reaction, hemoglobinuria, and HDN
which of the following MNS bgs can be formed in S-s individuals
a. Anti U
b. Anti - M
c. Anti - N
d. Anti-Nf
Anti- U ✓ U- universal ✓ Rare but can be formed in S-s- individuals, found on black people ✓ Can also cause HDN ✓ Enhanced by Enzyme treatment
