minor bgs II Flashcards
carried on the hematopoietic isoform of the CD44 marker, which is known for its immune adhesion properties
a. dombrock
b. indian
c. Ok
d. Raph
ISBT 023 INDIAN
Antigens: Ina , Inb
✓ IN antigens are carried on the hematopoietic isoform of the CD44 marker, which is known for its immune adhesion properties
which of the following BGS is mainly function is a receptors and adhesion molecules
a. dombrock
b. indian
c. Ok
d. Raph
ISBT 024 Ok
✓ The OK antigens are carried on CD147, or basigin, a member of the immunoglobulin superfamily that mainly functions as receptors and adhesion molecules
✓ Basigin is a receptor essential for invasion by Plasmodium falciparum
which of the following BGS is a receptor essential for invasion by Plasmodium falciparum
a. dombrock
b. indian
c. Ok
d. Raph
ISBT 024 Ok
✓ The OK antigens are carried on CD147, or basigin, a member of the immunoglobulin superfamily that mainly functions as receptors and adhesion molecules
✓ Basigin is a receptor essential for invasion by Plasmodium falciparum
is located on CD151, a tetraspanin, which appears to be essential for the assembly of basement membranes in the kidney and skin
a. dombrock
b. indian
c. Ok
d. Raph
ISBT 025 RAPH
✓ The only antigen in the Raph system is MER2
✓ It was shown that MER2 is located on CD151, a tetraspanin, which appears to be essential for the assembly of basement membranes in the kidney and skin
where does GILL located
a. AE1
b. chromosome 1
c. AQP3
d. ERMAP
ISBT 029 GILL
✓ The ISBT Gill system symbol is GIL and number 029. There is only one antigen, GIL.
✓ This antigen is found on the glycerol transporter AQUAPORIN 3 (AQP3), a member of the major intrinsic protein family of water and glycerol channels
Absence of RhAG due to inactivating mutations in RHAG results in the __________
A.. Rhmod phenotype
B. Rhnull phenotype
Absence of RhAG due to inactivating mutations in RHAG results in the Rhnull phenotype;
some missense mutations in RHAG result in the Rhmod phenotype.
which of the following are antigens in RHAG
a. duclos
b. ola
c. DSLG
d. aota
Four antigens have been assigned to the RHAG system:
Duclos (high prevalence),
Ola (very rare, low prevalence),
the high prevalence DSLK (for Duclos-like), and
RHAG4
The GBGTI gene produces ___________, which causes the formation of the Forssman glycolipid by the addition of N-acetylgalactosamine (GalNAc) to the P antigen.
a. glycosyltransferase
b. aquaporin 3
c. hematopoietic isoform
d. aota
isbt 031 FORS
The GBGTI gene produces glycosyltransferase, which causes the formation of the Forssman glycolipid by the addition of N-acetylgalactosamine (GalNAc) to the P antigen.
human cells that express the ______may have an increased susceptibility to E. coli infection.
a. JMH
b. GIL
c. FORS1
d. INa
ISBT 031 FORS
The Forssman glycolipid can serve as a receptor for pathogens such as Escherichia coli, making one believe that human cells that express the FORS1 may have an increased susceptibility to E. coli infection.
which o fthe following BGS The gene ABCG2 is located on chromosome 4 at position 4q22.1. Is a member of the adenosine triphosphate (ATP) binding cassette transporters broadly distributed throughout the body. It is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy
a. scianna
b. indian
c. GILL
d. JR
ISBT 032 JR
✓ Jra is a high-prevalence antigen in most populations; the Jr(a–) phenotype is found more commonly in Japanese
✓ The gene ABCG2 is located on chromosome 4 at position 4q22.1. The encoded protein, ABCG2, is a member of the adenosine triphosphate (ATP) binding cassette transporters broadly distributed throughout the body. It is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy
what gene is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy
a. ABCG1
b. ABCG2
c. DUCHLOS
d ABCG6
ISBT 032 JR
✓ Jra is a high-prevalence antigen in most populations; the Jr(a–) phenotype is found more commonly in Japanese
✓ The gene ABCG2 is located on chromosome 4 at position 4q22.1. The encoded protein, ABCG2, is a member of the adenosine triphosphate (ATP) binding cassette transporters broadly distributed throughout the body. It is involved in multidrug resistance in tumor cells, presenting a problem in chemotherapy
what is the gene involved in functions in heme synthesis with the ATP-dependent uptake of heme and porphyrins into mitochondria.
a. ABCG1
b. ABCG2
c. DUCHLOS
d ABCG6
The Lan gene, ABCB6, located on chromosome 2 at position 2q36, encodes another of the ATP-binding cassette transporters.4 ABCB6 functions in heme synthesis with the ATP-dependent uptake of heme and porphyrins into mitochondria.
what BGS is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).
a. CD59
b. GIL
c. SDa
d. JR
ISBT 035 CD59
✓ CD59 is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).
✓ CD59 plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).
_____ plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).
a. CD59
b. GIL
c. SDa
d. JR
ISBT 035 CD59
✓ CD59 is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).
✓ CD59 plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).
_____________is an acquired hemolytic anemia caused by a mutation in the GPI-linker gene.
a. PNH
b. PCH
c. Hodgkin’s lymphoma
d. aota
ISBT 035 CD59
✓ CD59 is a GPI-linked complement-regulatory glycoprotein also known as the membrane inhibitor of lysis (MIRL).
✓ CD59 plays a key role in protecting against complement regulated hemolysis by binding to C8 and C9 thus interfering with the formation of the membrane-attach complex (MAC).
✓ Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia caused by a mutation in the GPI-linker gene. PNH patients are deficient in all GPI-linked proteins, including CD59.
